2019
DOI: 10.1097/md.0000000000015389
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Negative pressure pulmonary edema after general anesthesia

Abstract: Rationale:Negative pressure pulmonary edema (NPPE) is a dangerous clinical complication and potentially life-threatening emergency without prompt diagnosis and intervention during recovery period after anesthetic extubation.Patient concerns:A 25-year-old woman has undergone endoscopic thyroidectomy. After extubation, the patient developed acute respiratory distress with high airway resistance accompanied with wheezing, oxyhemoglobin saturation (SpO2) decreased to 70%. With positive pressure mask ventilation, h… Show more

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Cited by 34 publications
(44 citation statements)
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“…However, this pathogenesis is contradicted in the present cases because there were no intracranial lesions or upper airway obstructions in the perioperative period. [ 15 ] Furthermore, the patients discussed in this case study were elderly, which is not supportive of the diagnosis of negative pressure PE, which mainly occurs in relatively younger patients.…”
Section: Discussionmentioning
confidence: 86%
“…However, this pathogenesis is contradicted in the present cases because there were no intracranial lesions or upper airway obstructions in the perioperative period. [ 15 ] Furthermore, the patients discussed in this case study were elderly, which is not supportive of the diagnosis of negative pressure PE, which mainly occurs in relatively younger patients.…”
Section: Discussionmentioning
confidence: 86%
“…In contrast, patients with NPPE caused by infection like epiglottitis need to obtain endotracheal intubation, cricothyroidotomy or tracheotomy [ 4 ]. The mechanical obstruction which could not be released by positive pressure, such as foreign body and postoperative tracheal stenosis, also must be introduced with invasive airway protection including endotracheal intubation, because the secure airway opening was the first step of treatment [ 10 ]. Therefore, if airway obstruction causing NPPE is not recognized promptly, prognosis of patients might be miserable and fatal [ 11 ].…”
Section: Discussionmentioning
confidence: 99%
“…In general, NPPE often demonstrates marked bilateral perihilar alveolar infiltrates on chest X-ray. Treatment modality includes supportive care such as careful post-op monitoring, reliving airway obstruction, oxygen supplementation, Bilevel Positive Airway Pressure (BIPAP) and assisted ventilation [61,62].…”
Section: Perioperative Negative Pressure Pulmonary Edema Versus Pulmomentioning
confidence: 99%