Negative‐pressure wound therapy for III/IV pressure injuries: A meta‐analysis

Abstract

This meta‐analysis was conducted to identify the potential benefits and the efficacy of negative‐pressure wound therapy (NPWT) for III/IV pressure injuries (PIs) compared with standard wound care (SWC). Sixteen RCTs with 629 patients were included in our analysis. The methodological quality was assessed by the Cochrane Collaboration Tool. The outcomes included complete ulcer healing rate, wound healing time, pain score, the frequency of dressing change, hospitalization cost, the condition of the exudate, and the wound improvement. The percentage of healing rate was 61.45% for the NPWT group and 36.90% for SWC (95% CI: 1.32‐1.70). There were significant differences in wound healing time (WMD = −16.47 days, 95% [CI (−22.36, − 10.59) days, P ≤ .001]). The pain score and hospitalization cost in NPWT was lower compared with SWC group (WMD = −2.39, 95% CI [−3.47, −1.30], P ≤ .001); (SMD = −2.55, 95% CI [−4.07, −1.03], P < .01). The frequency of dressing change in both NPWT groups was greatly reduced (SMD = −3.61, 95% [CI (−4.57, − 2.66) times, P ≤ .001]). Our meta‐analysis indicated that NPWT was associated with greater improvements in improving PIs and shorting healing time for III/IV PIs. However, this conclusion needs to be confirmed by high‐quality multicenter RCTs.

RETRACTED: Effects of negative‐pressure wound therapy in the prevention of surgical‐site wound infection after vascular surgery: A meta‐analysis

“…Negative‐pressure wound therapy (NPWT) employs an intelligent negative‐pressure suction system to create continuous or intermittent negative pressure in a sealed wound area, promoting wound healing through efficient drainage, infection control, and improved tissue perfusion 10–12 . An international expert panel consensus recommends the application of NPWT to various routine surgical incisions, including those in cardiothoracic, head and neck, general, orthopedic, and gynecological surgeries 13–17 .…”

Surgical Reconstruction of Stage 3 and 4 Pressure Injuries: A Literature Review and Proposed Algorithm from an Interprofessional Working Group

“…The use of NPWT for PI management and treatment is now the criterion standard and has available clinical evidence from case reports, case series, RCTs, and prospective real-world trials. Song et al 63 included 16 RCTs in a systematic review and meta-analysis, concluding that NPWT shortened the healing time of PIs and reduced dressing change frequency and overall hospitalization costs. As it relates to the surgical reconstruction of PIs, two variations of traditional NPWT have recently emerged that are additional tools for clinicians surgically treating PIs.…”

Unterdrucktherapie, Negative Pressure Wound Therapy (NPWT)

“…des Patientenkollektivs. Während mehrere randomisiert kontrollierte Studien bezüglich NPWT bei Wunden nach offenen Frakturen durchgeführt wurden, ist die Evidenzlage bei der Anwendung von NPWT an Druckulzera weniger stark 25 , 26 . Bezüglich der Instillationstherapie ist die Evidenzlage ähnlich wie bei der Standard-Vakuumtherapie anzusehen.…”