Negative pressure wound therapy versus standard care for incisional laparotomy subcutaneous wounds in gastrointestinal perforations: A randomized controlled study

Singh, Harjeet; Avudaiappan, Mohanasundaram; Kharel, Jyoti; Irrinki, Santosh; Kumar, Hitesh; Savlania, Ajay; Sharma, Vishal; Gupta, Vikas; Yadav, Thakur Deen; Gupta, Rajesh

doi:10.1016/j.surg.2023.04.018

Cited by 3 publications

(1 citation statement)

References 23 publications

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“…The reduction of SSI with the use of NPWT showed consistent results in various studies. 10,11,14,15 The routine use of NPWT is not in practice after PD due to limited evidence in PD. O'Neill et al 16 evaluated the role of NPWT in pancreatic resection surgery, but they did not find any significant benefit in the reduction of SSI.…”

Section: Discussionmentioning

confidence: 99%

Systematic Review and Meta-Analysis: Role of Negative Pressure Wound Therapy in Preventing Surgical Site Infections after Pancreaticoduodenectomy

Singh,

Irrinki,

Krishnamurthy

et al. 2023

Journal of Gastrointestinal Infections

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Background Surgical site infection (SSI) after pancreaticoduodenectomy is associated with significant morbidity, increased hospital stays, delay in adjuvant treatment, and overburden on hospital resources. There is no consensus in the management of these wounds. Methods We performed a systematic review. We searched the PubMed, Embase, and Scopus on March 23, 2022 for studies reporting on negative pressure wound therapy (NPWT) in patients operated on with pancreaticoduodenectomy. We included all studies that reported the comparative outcomes of NPWT in patients undergoing pancreaticoduodenectomy. All data were extracted by two reviewers separately. The pooled odds risk of SSI was calculated using the metabin command and Mantel–Haenszel approach.We assessed the risk of bias using Joanna Briggs Institute's critical appraisal tool for cohort studies. Results Four studies with 878 participants were included. The pooled odds ratio for SSI was lower in the NPWT group as compared with standard care (0.36; 95% confidence interval [CI]: 0.24–0.54; I 2 = 0). The pooled odds ratio of organ space infection was 0.40 (95% CI: 0.24–0.67; I 2 = 0) on the basis of three studies (484 participants). We did not perform any subgroup analyses because of lack of heterogeneity in the reported results and limited number of studies. Conclusion Pancreaticoduodenectomy is associated with high risk of SSI. The use of prophylactic NPWT after pancreaticoduodenectomy is associated with decreased risk of SSI. The cost–benefit ratio of NPWT over standard care requires further comparative study.

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