1993
DOI: 10.1016/0092-8674(93)90580-j
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Negative regulation of the weel protein kinase by direct action of the nim1/cdr1 mitotic inducer

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Cited by 178 publications
(153 citation statements)
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“…The role of Cdr2 as a mitotic inducer and the presence of the cell cycle regulatory kinases Cdr1 and Wee1 at medial cortical nodes has led to the hypothesis that during interphase, medial cortical nodes transduce the spatial information generated by Pom1 gradient to the cell cycle machinery [Martin and Berthelot-Grosjean, 2009;Moseley et al, 2009]: Wee1 phosphorylates the cyclin-dependent kinase Cdc2 to inhibit precocious mitotic entry [Gould and Nurse, 1989]; the SAD1-like kinases Cdr1/ Nim1 and Cdr2 [Coleman et al, 1993; Parker et al, 1993;Wu and Russell, 1993;Breeding et al, 1998;Kanoh and Russell, 1998] promote mitotic entry by inhibiting Wee1; Pom1, upstream of SAD1-kinases, has been shown to negatively regulate Cdr2 [Martin and Berthelot-Grosjean, 2009;Moseley et al, 2009]. These negative regulatory relationships together with the specific localization of Pom1 and Cdr2 within the cell lead to an elegant model explaining the coupling between mitosis entry and cell length.…”
Section: Pom1 Gradient and Medial Cortical Nodes Control Mitotic Entrymentioning
confidence: 99%
“…The role of Cdr2 as a mitotic inducer and the presence of the cell cycle regulatory kinases Cdr1 and Wee1 at medial cortical nodes has led to the hypothesis that during interphase, medial cortical nodes transduce the spatial information generated by Pom1 gradient to the cell cycle machinery [Martin and Berthelot-Grosjean, 2009;Moseley et al, 2009]: Wee1 phosphorylates the cyclin-dependent kinase Cdc2 to inhibit precocious mitotic entry [Gould and Nurse, 1989]; the SAD1-like kinases Cdr1/ Nim1 and Cdr2 [Coleman et al, 1993; Parker et al, 1993;Wu and Russell, 1993;Breeding et al, 1998;Kanoh and Russell, 1998] promote mitotic entry by inhibiting Wee1; Pom1, upstream of SAD1-kinases, has been shown to negatively regulate Cdr2 [Martin and Berthelot-Grosjean, 2009;Moseley et al, 2009]. These negative regulatory relationships together with the specific localization of Pom1 and Cdr2 within the cell lead to an elegant model explaining the coupling between mitosis entry and cell length.…”
Section: Pom1 Gradient and Medial Cortical Nodes Control Mitotic Entrymentioning
confidence: 99%
“…Two kinases in fission yeast, Cdr1 and Cdr2, were originally identified by the "changed division response"; when nitrogen becomes limiting, Cdr1 and Cdr2 inactivate Wee1 by phosphorylation of the catalytic domain, advancing the point of mitotic entry [39][40][41][42][43]. Under cycling conditions, deletion of cdr1, cdr2 or both has only a minor impact on cell cycle progression.…”
Section: Checkpoint Antagonistsmentioning
confidence: 99%
“…These include the p34cdc2 tyrosine kinase pathway, which is regulated by serine/threonine phosphorylation (21) and the phosphorylation of p34Cdc2 .…”
Section: Methodsmentioning
confidence: 99%