Negative Signs and Symptoms Secondary to Antipsychotics: A Double-Blind, Randomized Trial  of a Single Dose of Placebo, Haloperidol,  and Risperidone in Healthy Volunteers

Artaloytia, Juan Francisco; Arango, Celso; Lahti, Adrienne C.; Sanz, Javier; Pascual, Ana; Cubero, Pedro; Prieto, David; Palomo, Tomás

doi:10.1176/appi.ajp.163.3.488

Cited by 123 publications

(84 citation statements)

References 26 publications

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“…dopaminergic antagonist infusion either systemically 100 , or within the nucleus accumbens 101 substantially reduces response vigor in food seeking behavior or, otherwise bias action selection away from effortful choices, even when reward offers are considered worthy. It is well known that patients under high dopamine receptor antagonism can display severe apathetic behavior 102 . Further support for this notion is found in non-primate research on drug seeking behavior reinstatement, which is a suitable model of drug addiction relapse after a period of abstinence 103 .…”

Section: Ventromedial Prefrontal Cortex and Dopamine: Decoding Decisimentioning

confidence: 99%

Neurobiology of apathy in Alzheimer's disease

Guimarães

Lévy²,

Teixeira

et al. 2008

Arq. Neuro-Psiquiatr.

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-Apathy is considered the most frequent neuropsychiatric disturbance in dementia and its outcome is generally deleterious. Apathy can be related to a dysfunction of the anatomical-system that supports the generation of voluntary actions, namely the prefrontal cortex and/or the prefrontal-subcortical circuits. In Alzheimer's disease, pathological and neuroimaging data indicate that apathy is likely due to a dysfunction of the medial prefrontal cortex. Accordingly, in this review article, we propose a pathophysiological model to explain apathetic behavior in Alzheimer's disease, combining data from neuroimaging, neuropathology and experimental research on the role of orbito-frontal cortex, anterior cingulate cortex, basal ganglia and dopamine in decision-making neurobiology.Key words: apathy, Alzheimer's disease, decision-making, orbito-frontal cortex, anterior cingulate cortex, basal ganglia, dopamine. Neurobiologia da apatia na doença de alzheimerResumo -Apatia é considerada a alteração neuropsiquiátrica mais freqüente nas demências e suas conseqüências são habitualmente deletérias. Apatia pode ser relacionada à disfunção do sistema anatômico responsável pela geração de ações voluntárias, conhecido com córtex pré-frontal e/ou circuitos pré-frontais-subcorticais. Na doença de Alzheimer, evidências neuropatológicas e de neuroimagem funcional indicam que a apatia é provavelmente decorrente da disfunção do córtex pré-frontal medial. Assim, neste artigo de revisão, apresentamos uma proposta de um modelo fisiopatológico para explicar o comportamento apático na doença de Alzheimer, combinando dados de neuropatologia, neuroimagem e experimentação animal sobre o papel do córtex órbito-frontal, cíngulo anterior, núcleos da base e dopamina na neurobiologia da tomada de decisão.PAlAvrAs-chAve: apatia, doença de Alzheimer, tomada de decisão, córtex órbito-frontal, córtex cingulado anterior, núcleos da base, dopamina.

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Section: Ventromedial Prefrontal Cortex and Dopamine: Decoding Decisimentioning

confidence: 99%

Neurobiology of apathy in Alzheimer's disease

Guimarães

Lévy²,

Teixeira

et al. 2008

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

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“…However, studies of healthy volunteers offer indications. Artaloytia et al (2006) reported that single doses of haloperidol, and particularly of risperidone, produced negative symptoms in healthy volunteers. Park et al (2012) likewise found that a single dose of risperidone induced negative symptoms (including increased avolition), although they concluded that haloperidol, amisulpride and aripiprazole did not.…”

Section: Medication and Boredommentioning

confidence: 99%

Boredom among psychiatric in-patients: does it matter?

Steele¹,

Henderson²,

Lennon³

et al. 2013

Adv. psychiatr. treat

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SummaryMany psychiatric in-patients report boredom. Such complaints may appear trivial, but this literature review by a clinical librarian suggests that boredom is more complex than may initially appear and relates to wider areas of importance for in-patient psychiatric teams. Boredom may relate to the internal experience of meaning, which itself encompasses meaningful relationships and roles and a sense of control. Although meaningful therapeutic activities are vital, mental health professionals should focus on the internal as well as the external dimensions of boredom. Medications, particularly dopamine antagonist antipsychotics, may be a contributing factor. This article highlights the benefits of the clinical librarian role in synthesising research in mental health. Research can illuminate psychiatric practice in a more holistic way than purely by applying 'scientific' evidence in the practice of ‘biological’ psychiatry.

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“…Ausgeprägte extrapyramidale Störungen sind zwar seit der Einführung der Antipsychotika der zweiten Generation und vorsichtigeren Dosierungsrichtlinien seltener geworden. Man darf jedoch nicht unterschätzen, dass auch diskrete extrapyramidale Symptome für Negativsymptome g ehalten werden können und daher bei der Diagnostik berücksichtigt werden sollten [29,30] [34].…”

Section: Primäre Versus Sekundäre Negativsymptomeunclassified

Update: Negativsymptome. Psychopathologie, Epidemiologie, Pathophysiologie und Behandlungsoptionen.

2013

Swiss Arch Neurol Psychiatr

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SummaryUpdate: Negative symptoms. Psychopathology, epidemiology, pathophysiology and treatment options The negative symptoms of schizophrenia include blunted affect, alogia, a sociality, avolition and anhedonia. These symptoms are back in the focus of research owing to their strong impact on the functional ability and quality of life of individuals with schizophrenia. Psychopathological research has led to a consensus about the relevant symptoms and their measurement. N eurocognitive research approaches mainly view negative symptoms as a dysfunction of goal-directed behaviour and pathophysiological processes in the underyling brain stuctures. Treatment with second generation antipsychotics as well as add-on drugs shows only moderate effect. Cognitive b ehavioural therapy approaches are promising, but there are only a few s tudies focusing on negative symptoms. This article provides an overview on the current state of research on the psychopathology, epidemiology, pathophysiology and treatment options of negative symptoms.

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Negative Signs and Symptoms Secondary to Antipsychotics: A Double-Blind, Randomized Trial of a Single Dose of Placebo, Haloperidol, and Risperidone in Healthy Volunteers

Abstract: Single doses of both haloperidol and risperidone produce negative symptoms in normal individuals. Drowsiness may be an important confounding factor in the assessment of negative symptoms in antipsychotic trials.

Cited by 123 publications

References 26 publications

Neurobiology of apathy in Alzheimer's disease

Neurobiology of apathy in Alzheimer's disease

Boredom among psychiatric in-patients: does it matter?

Update: Negativsymptome. Psychopathologie, Epidemiologie, Pathophysiologie und Behandlungsoptionen.

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