Negative symptoms and psychosocial status in temporal lobe epilepsy

Getz, Kiesa; Hermann, Bruce P.; Seidenberg, Michael; Bell, Brian; Dow, Christian; Jones, Jana E.; Woodard, Austin

doi:10.1016/s0920-1211(03)00033-0

Cited by 14 publications

(10 citation statements)

References 10 publications

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“…The generally higher HRQoL level in majority of subscales among married patients compared to their unmarried and widowed/divorced counterparts (discovered via univariate analysis) is comparable to another study among patients with temporal lobe epilepsy who experienced negative symptoms (Getz et al 2003). This was particularly apparent among respondents with Poor QoL whereby in addition to experiencing significantly less energy than the married group, the widows/widowers/ divorcees were also having the worst level of Social Functioning, most likely due the unpleasant consequences of spouse death or failed marriages.…”

Section: Discussionsupporting

confidence: 73%

The Impact of Demographic Characteristics on Health-related Quality of Life Profile of Malaysian Epilepsy Population

Lua

Haron

Cosmas

et al. 2007

Applied Research Quality Life

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The possibilities of adverse drug reactions and disease-related psychosocial implications have led to the current emphasis on health-related quality of life (HRQoL) assessment in epilepsy. The main objective of this study was to determine the impact of various demographic characteristics i.e. gender, age, marital status, ethnic origin, religion, and employment status on HRQoL profiles in Malaysian epilepsy patients. Patients with epilepsy were recruited from ten public hospitals in Sabah, Malaysia. Upon written consents, they completed the Malay Quality of Life In Epilepsy-30 (QOLIE-30) instrument which assesses Seizure Worry, Overall QoL, Emotional Well-Being, Energy/Fatigue, Cognitive Functioning, Medication Effects and Social Functioning. An Overall Score was generated to represent a summarised HRQoL score. Univariate and multiple linear regression analyses were both carried Applied Research Quality Life (

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Section: Discussionsupporting

confidence: 73%

The Impact of Demographic Characteristics on Health-related Quality of Life Profile of Malaysian Epilepsy Population

Lua

Haron

Cosmas

et al. 2007

Applied Research Quality Life

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“…Negative symptoms including affective flattening, alogia and avolition, anergia, apathy, anhedonia, and loss of social drive have been reported in patients with TLE 116,117. These patients also exhibit cognitive and psychosocial correlates that are not seen in patients with TLE without negative symptoms, but neuroimaging correlations with cortical regions were nonspecific and limited only to increased total CSF 116,117.…”

Section: Linking Distributed Cognitive Impairments With Distributed Nmentioning

confidence: 99%

“…These patients also exhibit cognitive and psychosocial correlates that are not seen in patients with TLE without negative symptoms, but neuroimaging correlations with cortical regions were nonspecific and limited only to increased total CSF 116,117. Geary and coworkers118 hypothesized that basal ganglia and anterior cingulate regions of interest play a role in the expression of negative symptoms in epilepsy and compared a matched group of TLE patients with and without negative symptoms with healthy controls (N = 22 per group).…”

Section: Linking Distributed Cognitive Impairments With Distributed Nmentioning

confidence: 99%

The Emerging Architecture of Neuropsychological Impairment in Epilepsy

Hermann¹,

Lin²,

Jones³

et al. 2009

Neurologic Clinics

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A new literature is now under way, one linking cognitive abnormalities directly to indices of structural, functional, metabolic, and other neurobiologic markers of cerebral integrity, independent of their association with clinical epilepsy characteristics. These trends are reviewed in this article. The focus is on temporal lobe epilepsy (TLE) as a model with which to address the core points because this form of localization-related epilepsy has been very carefully studied from both a cognitive and imaging standpoint. Some pertinent historical issues are touched on first, followed by more detailed reviews of the cognitive and neuroimaging abnormalities that have been found in TLE, followed by an overview of studies examining direct structure-function relationships in TLE and other epilepsies.

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“…As schizophrenia is also associated with social difficulties and at least a certain proportion of patients with schizophrenia and epilepsy share a similar pattern of neuropsychological deficits of speed of processing, memory and executive functions, insight into these approaches are even more relevant. There is also evidence of negative symptoms, one of the psychopathological features of schizophrenia, in patients with epilepsy, which are associated with abnormalities in brain structure and cognition, similar to that found in schizophrenia [71]. These negative symptoms include alogia, avolition, anhedonia and inattention, which are independent of current and past depression [72].…”

Section: Understanding Why Difficulties Arise In Social Competence Inmentioning

confidence: 84%

“…Therefore, it is necessary to address these and promote an intervention where the person is an active participant and the program is individually meaningful for them and their lives, congruent with their expectations and in keeping with their desired goal or goals. Furthermore, an approach which addresses social functioning should itself be motivating in that it is interesting, satisfying and encourages social interaction naturally and in its own right [71,72].…”

Section: Models Of Rehabilitation and Recoverymentioning

confidence: 99%

Quality of life is social – Towards an improvement of social abilities in patients with epilepsy

Szemere

Jokeit

2015

Seizure

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Quality of life (QoL) for people with epilepsy is considered worse than the condition's clinical and medical prognosis would predict. Quantity and quality of social interaction considerably determine QoL. Research shows that a significant proportion of patients with epilepsy experience difficulties with social functioning that is thought to be related to impaired QoL. The aim of this review article is to provide an evidence base for conceptualising and developing interventions to improve quality of life through social functioning, for adults with epilepsy. Previous and current research is considered initially with regards to why such difficulties arise and established interventions that address social competence and functioning are reviewed and explored from the field of schizophrenia, a condition also associated with similar difficulties in social cognition, cognition and negative symptoms. The paper considers the advantages and disadvantages of these interventions, the outcomes and emerging research in this area. Positive findings are found from interventional studies in schizophrenia such as the enhancing potential and generalisation of training in social cognition, the benefits of an integrated approach to improving social functioning and proposal of 'online' interaction approaches. These findings provide interesting and exciting directions for the ultimate goal towards interventions for the improvement of social functioning and quality of life in patients with epilepsy. This is of particular significance as at present there is currently no such dedicated program for people with epilepsy.

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Negative symptoms and psychosocial status in temporal lobe epilepsy

Cited by 14 publications

References 10 publications

The Impact of Demographic Characteristics on Health-related Quality of Life Profile of Malaysian Epilepsy Population

The Impact of Demographic Characteristics on Health-related Quality of Life Profile of Malaysian Epilepsy Population

The Emerging Architecture of Neuropsychological Impairment in Epilepsy

Quality of life is social – Towards an improvement of social abilities in patients with epilepsy

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