Negative symptoms in bipolar disorder and schizophrenia: A psychometric evaluation of the brief negative symptom scale across diagnostic categories

Strauss, Gregory P.; Vertinski, Mary; Vogel, Sally J.; Ringdahl, Erik N.; Allen, Daniel N.

doi:10.1016/j.schres.2015.12.014

Cited by 55 publications

(44 citation statements)

References 29 publications

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“…Positive and negative symptoms are independent of each other (15). A negative symptom is a reduction or loss of the normal function, consisting of a defective function, such as poor thought, bleak emotion, depression and passive social withdrawal.…”

Section: Discussionmentioning

confidence: 99%

Magnetic resonance imaging DTI-FT study on schizophrenic patients with typical negative first symptoms

Zhang

Wei

et al. 2016

Experimental and Therapeutic Medicine

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Magnetic resonance imaging (MRI) with diffusion-tensor imaging (DTI) together with a white matter fiber tracking (FT) technique was used to assess different brain white matter structures and functionalities in schizophrenic patients with typical first negative symptoms. In total, 30 schizophrenic patients with typical first negative symptoms, comprising an observation group were paired 1:1 according to gender, age, right-handedness, and education, with 30 healthy individuals in a control group. Individuals in each group underwent routine MRI and DTI examination of the brain, and diffusion-tensor tractography (DTT) data were obtained through whole brain analysis based on voxel and tractography. The results were expressed by fractional anisotropy (FA) values. The schizophrenic patients were evaluated using a positive and negative symptom scale (PANSS) as well as a Global Assessment Scale (GAS). The results of the study showed that routine MRIs identified no differences between the two groups. However, compared with the control group, the FA values obtained by DTT from the deep left prefrontal cortex, the right deep temporal lobe, the white matter of the inferior frontal gyrus and part of the corpus callosum were significantly lower in the observation group (P<0.05). The PANSS positive scale value in the observation group averaged 7.7±1.5, and the negative scale averaged 46.6±5.9, while the general psychopathology scale averaged 65.4±10.3, and GAS averaged 53.8±19.2. The Pearson statistical analysis, the left deep prefrontal cortex, the right deep temporal lobe, the white matter of the inferior frontal gyrus and the FA value of part of the corpus callosum in the observation group was negatively correlated with the negative scale (P<0.05), and positively correlated with GAS (P<0.05). In conclusion, a decrease in the FA values of the left deep prefrontal cortex, the right deep temporal lobe, the white matter of the inferior frontal gyrus and part of the corpus callosum may be associated with schizophrenia with typical first negative symptoms and the application of MRI DTI-FT can improve diagnostic accuracy.

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Section: Discussionmentioning

confidence: 99%

Magnetic resonance imaging DTI-FT study on schizophrenic patients with typical negative first symptoms

Zhang

Wei

et al. 2016

Experimental and Therapeutic Medicine

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“…Negative symptoms (NS) have been proposed as such a construct (Strauss et al , 2016). Originally considered as a hallmark symptom complex of schizophrenia (Kraepelin, 1921), it has become evident that NS also occur outside of the schizophrenia-spectrum (Strauss and Cohen, 2017).…”

Section: Introductionmentioning

confidence: 99%

“…This differentiation might therefore be critical for the development of effective treatment (Galderisi et al , 2018, Kaiser et al , 2017). With respect to the relevance of NS in BD several studies have reported elevated NS scores even in euthymic patients (Hawkins et al , 1997, Mancuso et al , 2015, Strauss et al , 2016), which are strongly associated with functional impairments (Atre-Vaidya et al , 1998, Samalin et al , 2016, Serafini et al , 2018). Studies comparing the severity of negative symptoms between SZ and BD yield mixed results (Strauss and Cohen, 2017, Tso et al , 2014) but suggest that NS might be more stable and trait like in SZ.…”

Section: Introductionmentioning

confidence: 99%

“…Studies comparing the severity of negative symptoms between SZ and BD yield mixed results (Strauss and Cohen, 2017, Tso et al , 2014) but suggest that NS might be more stable and trait like in SZ. With respect to the two negative symptom dimensions a recent study found that BD patients only differed from SZ patients on the diminished expression dimension but showed similar severity of apathy (Strauss et al , 2016). Furthermore, several studies have reported residual anhedonic symptoms in euthymic BD patients, which were comparable to SZ patients (Di Nicola et al , 2013, Tso et al , 2014) and relevant for impaired reward learning (Pizzagalli et al , 2008).…”

Section: Introductionmentioning

confidence: 99%

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Shared and dissociable features of apathy and reward system dysfunction in bipolar I disorder and schizophrenia

Kirschner

Cathomas

Manoliu

et al. 2019

Preprint

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BackgroundBipolar disorder I (BD-I) is defined by episodes of mania, depression, and euthymic states. These episodes are among other symptoms characterized by altered reward processing and negative symptoms (NS), in particular apathy. However, the neural correlates of these deficits are not well understood.MethodsWe first assessed the severity of negative symptoms in 25 euthymic BD-I patients compared to 25 healthy controls (HC) and 27 patients with schizophrenia (SZ). Then, we investigated ventral and dorsal striatal activation during reward anticipation in a Monetary Incentive Delayed Task and its association with NS.ResultsIn BD-I patients NS were clearly present and the severity of apathy was comparable to SZ patients. Apathy scores in the BD-I group but not in the SZ group correlated with sub-syndromal depression scores. At the neural level, we found significant ventral and dorsal striatal activation in BD-I patients and no group differences with HC or SZ patients. In contrast to patients with SZ, apathy did not correlate with striatal activation during reward anticipation. Explorative whole brain analyses revealed reduced extra-striatal activation in BD-I patients compared to HC and an association between reduced activation of the inferior frontal gyrus and apathy.ConclusionThis study found that in BD-I patients apathy is present to an extent comparable to schizophrenia, but is more strongly related to sub-syndromal depressive symptoms. The findings support the view of different pathophysiological mechanisms underlying apathy in the two disorders and suggest that extra-striatal dysfunction may contribute to impaired reward processing and apathy in BD-I.

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“…Most research to date on the association of psychosocial risk factors with psychosis has focused on SZ psychoses (Ayesa-Arriola et al, 2016;Compton, Kelley, & Ionescu, 2014;Crow, 1990;Jablensky, 2006). There have, in addition, been several studies comparing psychosocial factors in SZ, manic psychoses (MP) and schizoaffective (SA) psychoses in FEP; the results of these studies identify SA psychosis as an intermediate phenotype between SZ and bipolar disorder (BD), including on psychosocial variables such as age, education and marital status (Benabarre et al, 2001;Cannon, Jones, Gilvarry et al, 1997;Cheniaux, Landeira-Fernandez, Telles et al, 2008;Conus, Cotton, Schimmelmann, McGorry, & Lambert, 2007;Murray et al, 2004;Parellada, Castro-Fornieles, Gonzalez-Pinto et al, 2015;Strauss, Vertinski, Vogel, Ringdahl, & Allen, 2016;Tamminga, Ivleva, Keshavan et al, 2013;Tondo, Vázquez, Baethge et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Clinical and demographic differences between patients with manic, depressive and schizophrenia‐spectrum psychoses presenting to Early Intervention Services in London

Kapila

Fisher

Major

et al. 2017

Early Intervention Psych

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Negative symptoms in bipolar disorder and schizophrenia: A psychometric evaluation of the brief negative symptom scale across diagnostic categories

Cited by 55 publications

References 29 publications

Magnetic resonance imaging DTI-FT study on schizophrenic patients with typical negative first symptoms

Magnetic resonance imaging DTI-FT study on schizophrenic patients with typical negative first symptoms

Shared and dissociable features of apathy and reward system dysfunction in bipolar I disorder and schizophrenia

Clinical and demographic differences between patients with manic, depressive and schizophrenia‐spectrum psychoses presenting to Early Intervention Services in London

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