Negative symptoms in the elderly patient with dementia

Reichman, William E.; Negrón, Arnaldo E.

doi:10.1002/1099-1166(200112)16:1+<::aid-gps566>3.0.co;2-s

Cited by 39 publications

(27 citation statements)

References 30 publications

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“…Agitation and apathy were not found to be predictive of BDP performance. The finding that the proposed model containing agitation, apathy scores, and the covariates of physical health and age predict performance (as measured by the KI-ADL and RADL scales) is consistent with previous research indicating that these factors negatively impact ADLs [16]. Demonstrating this relationship infers a theoretical basis to demonstrate how MSBT may improve independence in ADL functioning, by reducing agitation and apathy.…”

Section: Discussionsupporting

confidence: 86%

The Effects of Snoezelen (Multi-Sensory Behavior Therapy) and Psychiatric Care on Agitation, Apathy, and Activities of Daily Living in Dementia Patients on a Short Term Geriatric Psychiatric Inpatient Unit

Staal

Sacks

Matheis

et al. 2007

Int J Psychiatry Med

101

106

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A randomized, controlled, single-blinded, between group study of 24 participants with moderate to severe dementia was conducted on a geriatric psychiatric unit. All participants received pharmacological therapy, occupational therapy, structured hospital environment, and were randomized to receive multi sensory behavior therapy (MSBT) or a structured activity session. Greater independence in activities of daily living (ADLs) was observed for the group treated with MSBT and standard psychiatric inpatient care on the Katz Index of Activities of Daily Living (KI-ADL; P = 0.05) than standard psychiatric inpatient care alone. The combination treatment of MSBT and standard psychiatric care also reduced agitation and apathy greater than standard psychiatric inpatient care alone as measured with the Pittsburgh Agitation Scale and the Scale for the Assessment of Negative Symptoms in Alzheimer's Disease (P = 0.05). Multiple regression analysis predicted that within the multi-sensory group, activities of daily living (KI-ADL) increased as apathy and agitation reduced (R2 = 0.42; p = 0.03). These data suggest that utilizing MSBT with standard psychiatric inpatient care may reduce apathy and agitation and additionally improve activities of daily living in hospitalized people with moderate to severe dementia more than standard care alone.

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Section: Discussionsupporting

confidence: 86%

The Effects of Snoezelen (Multi-Sensory Behavior Therapy) and Psychiatric Care on Agitation, Apathy, and Activities of Daily Living in Dementia Patients on a Short Term Geriatric Psychiatric Inpatient Unit

Staal

Sacks

Matheis

et al. 2007

Int J Psychiatry Med

101

106

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“…Avoiding social contacts is an aspect frequently observed in autism spectrum disorders (ASDs), where persistent deficits in social communication and social interaction is one of the core deficits (Lord, Elsabbagh, Baird, & Veenstra-Vanderweele, 2018). Additionally, social withdrawal is a common feature in Major Depressive Disorder (MDD) (Bora & Berk, 2016;Kupferberg, Bicks, & Hasler, 2016), SChiZophrenia (SCZ) Galderisi, Mucci, Buchanan, & Arango, 2018;Green, Horan, & Lee, 2015) and BiPolar disorder (BP) (Filizer, Cerit, Tuzun, & Aker, 2016) and also observed in neurological disorders like Alzheimer's disease (AD) (Dickerson, 2015;Reichman & Negron, 2001;Winograd-Gurvich, Fitzgerald, Georgiou-Karistianis, Bradshaw, & White, 2006). Difficulties in sociability can therefore potentially be seen as a cross-disorder overlapping trait in these frequently co-occurring disorders (i.e.…”

Section: Introductionmentioning

confidence: 99%

Genetic underpinnings of sociability in the UK Biobank

Bralten

Klemann

Mota

et al. 2019

Preprint

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Difficulties with sociability include a tendency to avoid social contacts and activities, and to prefer being alone rather than being with others. While sociability is a continuously distributed trait in the population, decreased sociability represent a common early manifestation of multiple neuropsychiatric disorders such as Schizophrenia (SCZ), Bipolar Disorder (BP), Major Depressive Disorder (MDD), Autism Spectrum Disorders (ASDs), and Alzheimer's disease (AD). We aimed to investigate the genetic underpinnings of sociability as a continuous trait in the general population. In this respect, we performed a genome-wide association study (GWAS) using a sociability score based on 4 social functioning-related self-report questions in the UK Biobank sample (n=342,461) to test the effect of individual genetic variants. This was followed by LD score analyses to investigate the genetic correlation with psychiatric disorders (SCZ, BP, MDD, ASDs) and a neurological disorder (AD) as well as related phenotypes (Loneliness and Social Anxiety). The phenotypic data indeed showed that the sociability score was decreased in individuals with ASD, (probable) MDD, BP and SCZ, but not in individuals with AD. Our GWAS showed 604 genome-wide significant SNPs, coming from 18 independent loci (SNP-based h2=0.06). Genetic correlation analyses showed significant correlations with SCZ (rg=0.15, p=9.8e-23), MDD (rg=0.68, and ASDs (rg=0.27,, but no correlation with BP (rg=0.01, p=0.45) or AD (rg=0.04, p=0.55). Our sociability trait was also genetically correlated with Loneliness (rg=0.45, p=2.4e-8) and Social Anxiety (rg=0.48, p=0.002). Our study shows that there is a significant genetic component to variation in population levels of sociability, which is relevant to some psychiatric disorders (SCZ, MDD, ASDs), but not to BP and AD.

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“…Adams and colleagues (2008) observed that referral for dementia evaluation for those with DS was triggered by behavioral excess, and the effect of behavioral change on the provision of care . Examples of behavioral change include both deficits and excesses (e.g., agitation and restlessness, sleep disturbance, withdrawal; Doody et al 1995;Petry et al 1988;Reichman and Negron 2001).…”

Section: Dementia In Down Syndromementioning

confidence: 99%