Negative symptoms of psychosis: A life course approach and implications for prevention and treatment

Lyne, John; O’Donoghue, Brian; Roche, Eric; Renwick, Laoise; Cannon, Mary; Clarke, Mary

doi:10.1111/eip.12501

Cited by 30 publications

(23 citation statements)

References 140 publications

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“…In addition to the sum score of core NS, the group effect became significant for items N1, N4 and D4, though only at a small to moderate effect size (Rosenthal's r: 0.196-0.235). Furthermore, longitudinal analyses revealed that, in line with reports in other clinical samples (Lyne et al, 2018), core NS predominately remained stable over time (i.e. persistently absent or present at baseline and follow-up in 73% of cases).…”

Section: Prevalence Severity and Course Of Ns In 22q11dssupporting

confidence: 82%

“…Interesting, these numbers are in line with the trajectory of positive symptoms (see also Schneider et al, 2013;Tang et al, 2017), which might indicate a stronger co-variance of positive and negative symptoms in 22q11DS than in other clinical populations (in the present study, the course of positive and negative symptoms between baseline and follow-up was similar in almost 40% of the sample). In patients with psychosis, at least in the longer term, negative and positive symptoms likely have an independent longitudinal course, with negative symptoms displaying greater stability over time (Lyne et al, 2018). Future studies should explore in greater details the developmental course of psychotic symptoms over time in 22q11DS.…”

Section: Prevalence Severity and Course Of Ns In 22q11dsmentioning

confidence: 99%

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Prevalence, course and psychosis-predictive value of negative symptoms in 22q11.2 deletion syndrome

Schneider

Armando

Schultze‐Lutter

et al. 2019

Schizophrenia Research

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Background: The 22q11.2 deletion syndrome (22q11DS) is one of the highest known risk factors for schizophrenia and recent findings have highlighted the clinical relevance of ultra-high risk criteria in this population. However, studies in other at-risk populations have shown that the presence of negative symptoms (NS) is also of clinical relevance in predicting transition to psychosis. The present study examined in detail the presence and course of NS in 22q11DS, as well as their value in predicting transition to psychosis. Methods: A total of 111 participants aged between 8 and 33 years were assessed with the Structured Interview for Psychosis-Risk Syndromes (SIPS). A follow-up assessment was available for 89 individuals. Results: Core NS of at least moderate severity were present in 50.5% of the sample and were more severe in individuals meeting UHR criteria. They predominantly remained stable over time and their emergence between baseline and follow-up assessment was associated with significant functional decline. Some NS were significant predictors of conversion to psychosis and the emergence/persistence of psychosis risk. Conclusions: Altogether, these findings highlight that NS are core manifestations of psychosis in individuals with 22q11DS that strongly impact global functioning. The presence of NS should be a primary target of early therapeutic intervention in this population.

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Section: Prevalence Severity and Course Of Ns In 22q11dssupporting

confidence: 82%

Section: Prevalence Severity and Course Of Ns In 22q11dsmentioning

confidence: 99%

Prevalence, course and psychosis-predictive value of negative symptoms in 22q11.2 deletion syndrome

Schneider

Armando

Schultze‐Lutter

et al. 2019

Schizophrenia Research

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“…The current study was correlational; thus, the mechanisms through which negative symptoms and working memory affect social and role functioning are still not well understood. A parsimonious explanation is that there is often overlap in content between measurement of negative symptoms and cognitive, social, and role functioning [60,61]. For example, the Scale for the Assessment of Negative Symptoms (SANS) [62] includes items assessing impaired attention, and the Clinical Assessment Interview for Negative Symptoms (CAINS) [63] includes items assessing motivation and pleasure for social, recreational, and vocational activities.…”

Section: Discussionmentioning

confidence: 99%

Associations of psychotic-like experiences, related symptoms, and working memory with functioning

2020

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This study examined the association of spatial working memory and attenuated psychotic-like experiences and related symptoms with social and role functioning. Findings from this study suggest that symptom dimensions and working memory impairment were associated with diminished functioning across a variety of domains. Specifically, negative symptoms and working memory impairment were inversely associated with both social and role functioning, whereas positive and disorganized symptoms showed inverse associations with social functioning only. Symptom dimensions did not moderate cognitive and functional variables, although working memory and attenuated clinical symptoms had an additive effect on functioning. Post-hoc analyses examining symptom dimensions simultaneously showed negative symptoms to be the variable most strongly predictive of overall functioning. These findings suggest that even in a non-clinical sample, sub-threshold psychosis symptoms and cognition may influence people’s social and role functioning.

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“…Most sessions were applied in patients with ADHD (about 30 sessions), whereas number of sessions was smaller in patients with schizophrenia (10–20 sessions). Possibly, patients with ADHD are more able to undergo a large number of treatment sessions then patients with schizophrenia, which are more disabled when it comes to adhering treatment due to their negative symptoms ( 53 ). In the study by Nan et al ( 50 ), an intense 4-day neurofeedback training protocol was applied.…”

Section: Discussionmentioning

confidence: 99%

Neurofeedback Training for Psychiatric Disorders Associated with Criminal Offending: A Review

Fielenbach

Donkers

Spreen³

et al. 2018

Front. Psychiatry

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BackgroundEffective treatment interventions for criminal offenders are necessary to reduce risk of criminal recidivism. Evidence about deviant electroencephalographic (EEG)-frequencies underlying disorders found in criminal offenders is accumulating. Yet, treatment modalities, such as neurofeedback, are rarely applied in the forensic psychiatric domain. Since offenders usually have multiple disorders, difficulties adhering to long-term treatment modalities, and are highly vulnerable for psychiatric decompensation, more information about neurofeedback training protocols, number of sessions, and expected symptom reduction is necessary before it can be successfully used in offender populations.MethodStudies were analyzed that used neurofeedback in adult criminal offenders, and in disorders these patients present with. Specifically aggression, violence, recidivism, offending, psychopathy, schizophrenia, attention-deficit hyperactivity disorder (ADHD), substance-use disorder (SUD), and cluster B personality disorders were included. Only studies that reported changes in EEG-frequencies posttreatment (increase/decrease/no change in EEG amplitude/power) were included.ResultsDatabases Psychinfo and Pubmed were searched in the period 1990–2017 according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses, resulting in a total of 10 studies. Studies in which neurofeedback was applied in ADHD (N = 3), SUD (N = 3), schizophrenia (N = 3), and psychopathy (N = 1) could be identified. No studies could be identified for neurofeedback applied in cluster B personality disorders, aggression, violence, or recidivism in criminal offenders. For all treatment populations and neurofeedback protocols, number of sessions varied greatly. Changes in behavioral levels ranged from no improvements to significant symptom reduction after neurofeedback training. The results are also mixed concerning posttreatment changes in targeted EEG-frequency bands. Only three studies established criteria for EEG-learning.ConclusionImplications of the results for the applicability of neurofeedback training in criminal offender populations are discussed. More research focusing on neurofeedback and learning of cortical activity regulation is needed in populations with externalizing behaviors associated with violence and criminal behavior, as well as multiple comorbidities. At this point, it is unclear whether standard neurofeedback training protocols can be applied in offender populations, or whether QEEG-guided neurofeedback is a better choice. Given the special context in which the studies are executed, clinical trials, as well as single-case experimental designs, might be more feasible than large double-blind randomized controls.

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Negative symptoms of psychosis: A life course approach and implications for prevention and treatment

Cited by 30 publications

References 140 publications

Prevalence, course and psychosis-predictive value of negative symptoms in 22q11.2 deletion syndrome

Prevalence, course and psychosis-predictive value of negative symptoms in 22q11.2 deletion syndrome

Associations of psychotic-like experiences, related symptoms, and working memory with functioning

Neurofeedback Training for Psychiatric Disorders Associated with Criminal Offending: A Review

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