Negative Urine Pregnancy Tests in Gestational Trophoblastic Disease: A Diagnostic Dilemma

Abstract

ABSTRACT:Gestational trophoblastic disease is a broad disorder of abnormal fertilization of ovum. Early detection and treatment is the best approach to prevent mortality and morbidity of patients of gestational trophoblastic tumors. All trophoblastic cells produce hcg (human chorionic gonoadotropin) and can easily be detected in urine of pregnant ladies. When urine pregnancy test become negative in a highly suspected patient, the management becomes difficult. In this case, though the urine pregnancy tests were negative on several occasions, serum β hcg level was very high > 1500000 mIU/ml (positive) and patient was cured by chemotherapy.