Neglected tropical diseases as a barometer for progress in health systems in times of COVID-19

Ehrenberg, Nieves; Ehrenberg, John P.; Fontes, Gilberto; Gyapong, Margaret; Rocha, Eliana Maria Maurício da; Steinmann, Peter; Utzinger, Jürg; Zhou, Xiao‐Nong; Savigny, Don de

doi:10.1136/bmjgh-2020-004709

Cited by 11 publications

(23 citation statements)

References 29 publications

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“…Brazil accounts for 96% (57,582) of these cases. The incidence rate of VL increased from 1990 to 2018 by 52.9% in this country alone with an even higher increase in children under the age of 1 year (Ehrenberg et al, 2021). Leishmaniasis is correlated with malnutrition, population relocation, inadequate housing, weak immune system, lack of financial support, and primarily affects some of the poorest people on earth.…”

Section: Leishmaniasismentioning

confidence: 98%

Nano Based Approach for the Treatment of Neglected Tropical Diseases

Pandian

Panneerselvam

Pavadai

et al. 2021

Front. Nanotechnol.

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Neglected tropical diseases (NTDs) afflict more than one billion peoples in the world’s poorest countries. The World Health Organization (WHO) has recorded seventeen NTDs in its portfolio, mainly caused by bacterial, protozoal, parasitic, and viral infections. Each of the NTDs has its unique challenges on human health such as interventions for control, prevention, diagnosis, and treatment. Research for the development of new drug molecules against NTDs has not been undertaken by pharmaceutical industries due to high investment and low-returns, which results in limited chemotherapeutics in the market. In addition, conventional chemotherapies for the treatment of NTDs are unsatisfactory due to its low efficacy, increased drug resistance, short half-life, potential or harmful fatal toxic side effects, and drug incompetence to reach the site of parasite infection. In this context, active chemotherapies are considered to be re-formulated by overcoming these toxic side effects via a tissue-specific targeted drug delivery system. This review mainly emphasizes the recent developments of nanomaterial-based drug delivery systems for the effective treatment of NTDs especially sleeping sickness, leishmaniasis, chagas disease, soil-transmitted helminthiasis, african trypanosomiasis and dengue. Nanomaterials based drug delivery systems offer enhanced and effective alternative therapy through the re-formulation approach of conventional drugs into site-specific targeted delivery of drugs.

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Section: Leishmaniasismentioning

confidence: 98%

Nano Based Approach for the Treatment of Neglected Tropical Diseases

Pandian

Panneerselvam

Pavadai

et al. 2021

Front. Nanotechnol.

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“…The toll of NTDs on global health is far-fetched as they have a great impact on the poor in tropical regions. NTDs are influenced by water, sanitation, and hygiene (WASH) conditions that necessitate joint implementation, management, and evaluation of NTDs and WASH programs [1].…”

Section: Introductionmentioning

confidence: 99%

“…Neglected tropical diseases (NTDs) have been described as a diverse group of bacterial, parasitic, and viral diseases affecting more than one billion people [1]. These diseases cost developing economies billions of dollars every year with low-income countries disproportionately affected by ≥5 NTDs simultaneously [1,2]. The World Health Organization (WHO) increased the list of prioritized diseases to 20 in 2017 [1].…”

Section: Introductionmentioning

confidence: 99%

COVID‐19 and neglected tropical diseases among refugees: Plight of a vulnerable population in Africa

Ogunkola

Ogbodum

Nja

et al. 2023

Public Health Challenges

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Neglected tropical diseases (NTDs) are widespread in tropical and subtropical climates and caused by bacteria, fungi, parasites, and viruses. These infections have devastating physical, social, and economic impacts worldwide, especially in underveloped communities. Migrant populations, such as refugees who may carry diseases or are exposed to them for the first time, face poverty, famine, and bad living conditions. The pandemic's twofold burden and long‐term impact on NTDs among African refugees are highlighted in this article. Sub‐Saharan Africa accounts for roughly 90% of the disease burden due to poverty and some NTDs’ special propensity to thrive in its climates. After a disruption, such as displacement due to war, infectious disease transmission will rise until it reaches pre‐intervention levels if treatments are not started. COVID‐19 threatens NTD control and elimination efforts, which are now directly affected by it. Due to high population density, social isolation is difficult in most African refugee camps. In such circumstances, poor sanitation and lack of access to water make hand hygiene practically impossible. Over the past few decades, refugees and their settlements and camps have faced socioeconomic and health challenges. In order for vulnerable populations, like the refugees, not to be left behind, they should not be forgotten and countries should prepare for the revival of community‐based engagement.

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“…The spread of the coronavirus disease 2019 (COVID-19) pandemic in the past three years [ 1 , 2 ] has posed tremendous challenges for public health [ 3 ], hampering the control and surveillance of other infectious diseases, such as mosquito-borne diseases (MBDs) [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of Mosquito-Borne Viruses in Egypt: A Systematic Review

Fang

Khater

Xue

et al. 2022

Viruses

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There are at least five common mosquito-borne viruses (MBVs) recorded in Egypt, including dengue virus (DENV), Rift Valley fever virus (RVFV), West Nile virus (WNV), Chikungunya virus, and Sindbis virus. Unexpected outbreaks caused by MBVs reflect the deficiencies of the MBV surveillance system in Egypt. This systematic review characterized the epidemiology of MBV prevalence in Egypt. Human, animal, and vector prevalence studies on MBVs in Egypt were retrieved from Web of Science, PubMed, and Bing Scholar, and 33 eligible studies were included for further analyses. The monophyletic characterization of the RVFV and WNV strains found in Egypt, which spans about half a century, suggests that both RVFV and WNV are widely transmitted in this nation. Moreover, the seropositive rates of DENV and WNV in hosts were on the rise in recent years, and spillover events of DENV and WNV to other countries from Egypt have been recorded. The common drawback for surveillance of MBVs in Egypt is the lack of seroprevalence studies on MBVs, especially in this century. It is necessary to evaluate endemic transmission risk, establish an early warning system for MBVs, and develop a sound joint system for medical care and public health for managing MBVs in Egypt.

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Neglected tropical diseases as a barometer for progress in health systems in times of COVID-19

Cited by 11 publications

References 29 publications

Nano Based Approach for the Treatment of Neglected Tropical Diseases

Nano Based Approach for the Treatment of Neglected Tropical Diseases

COVID‐19 and neglected tropical diseases among refugees: Plight of a vulnerable population in Africa

Epidemiology of Mosquito-Borne Viruses in Egypt: A Systematic Review

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