Neglected tropical diseases in Brazil: lack of correlation between disease burden, research funding and output

Fonseca, Bruna de Paula Fonseca e; Albuquerque, Priscila Costa; Zicker, Fábio

doi:10.1111/tmi.13478

Cited by 30 publications

(32 citation statements)

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“…The analysis of scientific production contained in the bibliographic databases makes it possible to highlight countries´ investment gaps in priority issues for their inhabitants. This in turn can improve the uptake of evidence for health actions [ 22 ]. This is particularly relevant in LAC, the region of the world with the highest inequalities anywhere [ 23 ] and one significantly affected by tropical diseases [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Publication Trends in Neglected Tropical Diseases of Latin America and the Caribbean: A Bibliometric Analysis

2021

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(1) Background: Neglected tropical diseases (NTDs) have been overlooked on the global health agenda and in the priorities of national systems in low- and middle-income countries (LMICs). In 2012, the Sustainable Development Goals (SDGs) were created to ensure healthy lives and promoting well-being for all. This roadmap set out to accelerate work to overcome the global impact of NTDs. Almost a decade has passed since NTDs were re-launched as a global priority. Investment in research and development, as well as the production of scientific literature on NTDs, is expected to have increased significantly. (2) Methods: A bibliometric analysis of the scientific production of Latin America and the Caribbean (LAC) was carried out in relation to 19 endemic NTDs. These data were compared with the scientific production in malaria, tuberculosis, and HIV/AIDS. The database available from Thomson Reuters Web of Science (WoS) was used. In addition, the average annual growth percentage was calculated for each disease. (3) Results: In the last decade, the NTDs with the highest number of publications in the world were dengue and leishmaniasis. The United States was the most prolific country in the world in 15 out of 19 NTDs analyzed. In the LAC region, Brazil was the largest contributor for 16 of the 19 NTDs analyzed. Arboviral diseases showed the highest average annual growth. The number of publications for malaria, tuberculosis and HIV/AIDS was considerably higher than for NTDs. The contribution of most LAC countries, especially those considered to be LMICs, is inadequate and does not reflect the relevance of NTDs for the public health of the population. (4) Conclusion: This is the first bibliometric analysis to assess the trend of scientific documents on endemic NTDs in LAC. Our results could be used by decision makers both to strengthen investment policies in research and development in NTDs.

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Section: Introductionmentioning

confidence: 99%

Publication Trends in Neglected Tropical Diseases of Latin America and the Caribbean: A Bibliometric Analysis

2021

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“…The most common among these is research output, which is what we have used for this study. Due to the heterogeneous nature, it is important to focus on particular region(s) and/or disease(s), such as medical research in Africa (30), India (29) or Palestine (34), or specific chronic respiratory diseases in Europe (35), diabetes in five small countries in Europe (36), neglected tropical diseases in Brazil (37) or cancer research in 29 countries (24) or just in China (25). At the global level, Yegros-Yegros et al (38) use research output indexed by MEDLINE and WHO data from the Global Burden of Disease in 2010 to explore the relationships between research effort and health needs for 134 diseases.…”

Section: Introductionmentioning

confidence: 99%

How does academia respond to the burden of infectious and parasitic disease?

Zhao¹,

Wang²,

Zhang³

2021

Preprint

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Background: Academic research is one of the main avenues through which humans can fight the threat of infectious diseases. However, there has been concerns regarding whether academic system has provided sufficient efforts to fight infectious diseases we potentially face. Answering these questions could contribute to evidence-based recommendations for setting research priorities and third-mission policies. Methods: With a focus on one of the most common categories of communicable diseases, infectious and parasitic diseases (IPDs), we searched Web of Science for articles and reviews relevant to IPDs published during 2000-2019 and acquired WHO data of disease burden in corresponding years. The academic response patterns were explored by IPD subcategory, and by human development level (an index established by the UN). We in particular conduct the analysis to gain insight on the dynamic relationship between disease burden and research effort on IPD, scientific efforts contributed by countries with different development levels, and the variation trends in international joint efforts. Results: The greatest burden of IPD disease is clustered in the developing regions of Africa, but has received academic response from both developed and developing countries. Highly developed countries dominate the ranks of academic research in this area, yet there is also a clear increase of research efforts from the countries most affected, despite their low human development scale. In fact, the overall analysis reveals an improved capability of addressing local problems from African regions. In terms of international collaboration, highly developed countries, such as the US and UK, have commonly collaborated with needy regions, whereas prolific but developing nations, like China, have not. Conclusions: From a global perspective, academia has positively responded to health need caused by IPD. Although the relevant research output is primarily contributed by the highly developed countries, the concentrated efforts from the undeveloped regions to ease their local burdens can be clearly observed. Our findings also indicate the tendency on focusing more on local health needs for both developed and undeveloped regions. The insights revealed in this study should benefit a more informed and systemic plan of research priorities.

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“…Based on such calculations and the aforementioned circumstances of different ways of contagion, it is a matter of simple arithmetic prior to a successful nationwide vaccination to preview that the health of the entire country's population will be compromised in a variety of degrees. As it seems, South America is a hot spot of deaths by the COVID-19, based on fatal interpretations, premature, late or not given political decisions, lack of governmental leadership, a long-lasting economic crisis, corruption in high social-economic levels, in combination to unfunded health services, late and slow vaccination, as well as predominantly undisciplined public during the pandemic (Patiño et al, 2020;Burki et al, 2021;Herrera et al, 2021;Ortega et al, 2020;Fonseca et al, 2020;Joathan et al, 2021;Cardona-Ospina et https://dx.doi.org/10.15359/ru.36-1.17 URL: https://www.revistas.una.ac.cr/uniciencia E-ISSN: 2215-3470 Email: revistauniciencia@una.cr CC: BY-NC-ND 7 al., 2021). Based even on official statistics about contagion and fatalities of the COVID-19 pandemic, which, as demonstrated for the Ecuadorian case, are highly underrated, still, the outcoming numbers are of great concern.…”

Section: Resultsmentioning

confidence: 99%

Excess Mortality Data Analysis of COVID-19 Infections and Fatalities in Ecuador

Toulkeridis

Ortíz-Prado²,

Chunga-Moran

et al. 2022

Uniciencia

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The global COVID-19 pandemic has shocked the world. Since the virus gave rise to health problems and often ended in deaths, the count of the contagion and the deceased has been an open issue. Such statistics are vital for every nation and even every city or district and suburb as these numbers decide the level of intervention and the subsequent reduction of its given spread. Worldwide data show a mortality rate of around two percent prior to successful vaccination campaigns. However, Ecuador's statistical data indicate an abnormal amount of excess mortality, which is officially denied in each of the studied countries. These numbers have been projected on a monthly basis and exceed up to 300% of the official COVID-19 deaths. In particular, the average mortality rate in Ecuador, prior to and close to the pandemic, has been about 6083.4±234.6, while in the worst month during the sanitary crisis, deaths piled up to 21,000 people, and only 1180 were recognized as deceased by COVID-19. The reasons are widespread but based on an insufficient financed health sector, political incompetence, lack of leadership, and a long-lasting economic crisis. Therefore, premature endings of confinements or lockdowns have contributed to an accelerated contagion and seem to even counteract the vaccination phase, in middle 2021, shortly before excess mortality ceased completely.

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Neglected tropical diseases in Brazil: lack of correlation between disease burden, research funding and output

Cited by 30 publications

References 31 publications

Publication Trends in Neglected Tropical Diseases of Latin America and the Caribbean: A Bibliometric Analysis

Publication Trends in Neglected Tropical Diseases of Latin America and the Caribbean: A Bibliometric Analysis

How does academia respond to the burden of infectious and parasitic disease?

Excess Mortality Data Analysis of COVID-19 Infections and Fatalities in Ecuador

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