Negligible changes in piglet serum clinical indicators or organ weights due to dietary single-cell long-chain polyunsaturated oils

Huang, Meng‐Chuan; Chao, Angela Chueh; Kirwan, Ryan C; Tschanz, Carolyn L.; Peralta, José Mauro; Diersen-Schade, Deborah A.; Cha, Song; Brenna, J. Thomas

doi:10.1016/s0278-6915(01)00105-3

Cited by 18 publications

(14 citation statements)

References 19 publications

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“…Piglet growth is several-fold more rapid than for human infants, thus also refl ecting several fold greater intake and exposure to test substances than human infants ( 44 ). Others have shown that piglet lipoprotein characteristics depend on the source of DHA, whether TAG oil or egg PLs ( 45,46 ), a mechanism that may have been operating in our piglets to infl uence the relative amounts captured by the liver.…”

Section: Discussionmentioning

confidence: 99%

Higher efficacy of dietary DHA provided as a phospholipid than as a triglyceride for brain DHA accretion in neonatal piglets

Liu

Bartke

Daele

et al. 2014

Journal of Lipid Research

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Section: Discussionmentioning

confidence: 99%

Higher efficacy of dietary DHA provided as a phospholipid than as a triglyceride for brain DHA accretion in neonatal piglets

Liu

Bartke

Daele

et al. 2014

Journal of Lipid Research

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“…The sensitivity of heart ARA to the dietary ARA content has been reported from time to time in pigs (18,20) and rats (16,17). However, the underlying metabolic mechanisms are unknown and the clinical significance largely unstudied.…”

Section: Discussionmentioning

confidence: 99%

“…The sensitivity of heart ARA to dietary ARA content has been reported a few times but has not been systematically studied (16–18,20). In pigs (20), dietary ARA and DHA were maintained at a constant 2:1 ratio and total levels varied up to 5 times the target levels in formula.…”

Section: Introductionmentioning

confidence: 99%

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Heart arachidonic acid is uniquely sensitive to dietary arachidonic acid and docosahexaenoic acid content in domestic piglets

Tyburczy

Kothapalli

Park

et al. 2011

Prostaglandins, Leukotrienes and Essential Fatty Acids

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This study determined the sensitivity of heart and brain arachidonic acid (ARA) and docosahexaenoic acid (DHA) to the dietary ARA level in a dose-response design with constant, high DHA in neonatal piglets. On day 3 of age, pigs were assigned to 1 of 6 dietary formulas varying in ARA/DHA as follows (% fatty acid, FA/FA): (A1) 0.1/1.0; (A2) 0.53/1.0; (A3-D3) 0.69/1.0; (A4) 1.1/1.0; (D2) 0.67/0.62; (D1) 0.66/0.33. At necropsy (day 28) higher levels of dietary ARA were associated with increased heart and liver ARA, while brain ARA remained unaffected. Dietary ARA had no effect on tissue DHA accretion. Heart was particularly sensitive, with pigs in the intermediate groups having different ARA (A2, 18.6 ± 0.7%; A3, 19.4 ± 1.0%) and a 0.17% increase in dietary ARA resulted in a 0.84% increase in heart ARA. Further investigations are warranted to determine the clinical significance of heart ARA status in developing neonates.

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“…Higher doses are needed to account for increased metabolic rates in small animals; they may also shed light on any issues with toxicity. The safety of DHA, as contained in algal-DHA, has been evaluated in several animal studies [36,[39][40][41][42][43][44]. These studies included tests for genetic, acute, subchronic, and developmental toxicity.…”

Section: Discussionmentioning

confidence: 99%

The Hypolipidemic Effect of an Ethyl Ester of Algal‐Docosahexaenoic Acid in Rats Fed a High‐Fructose Diet

Ryan¹,

Bailey-Hall²,

Nelson³

et al. 2009

Lipids

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Preclinical and clinical studies demonstrate that the omega-3 fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) as a triacylglycerol (TAG) or an ethyl ester are protective against cardiovascular disease. Both have significant TAG-lowering effects. We developed a concentrated ethyl ester of DHA (MATK-90, 900 mg/g) using microalgae as its source. This study evaluated the effects that different doses of MATK-90 had on lipid levels and clinical parameters in male Wistar rats fed a high-fructose diet used to induce hypertriglyceridemia (TAG > or = 300 mg/dL). Effects of MATK-90 were compared to those produced by a pharmaceutical product (Lovaza, formerly Omacor, P-OM3; 465 mg EPA + 375 mg DHA), a TAG oil used in food (DHASCO, algal-DHA, 40% DHA by weight), and a control (corn oil). Doses of MATK-90 (0.6, 1.3, 2.5, 5.0 g kg(-1) day(-1)), algal-DHA (2 g DHA kg(-1) day(-1)), and P-OM3 (5.0 g kg(-1) day(-1)) were administered by oral gavage for 28 days. A significant dose-related decrease was observed in TAG and cholesterol levels in all but the lowest dose of MATK-90 treatment group vs. control. The high-dose group of MATK-90 and the P-OM3 group produced similar reductions in TAG levels.

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Negligible changes in piglet serum clinical indicators or organ weights due to dietary single-cell long-chain polyunsaturated oils

Cited by 18 publications

References 19 publications

Higher efficacy of dietary DHA provided as a phospholipid than as a triglyceride for brain DHA accretion in neonatal piglets

Higher efficacy of dietary DHA provided as a phospholipid than as a triglyceride for brain DHA accretion in neonatal piglets

Heart arachidonic acid is uniquely sensitive to dietary arachidonic acid and docosahexaenoic acid content in domestic piglets

The Hypolipidemic Effect of an Ethyl Ester of Algal‐Docosahexaenoic Acid in Rats Fed a High‐Fructose Diet

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