For college students, interpersonal skills (IS) are very necessary for them to build social networks and gain entrepreneurial resources, the level of their IS has a certain influence on their entrepreneurial performance (EP), and it’s needful to explore the mechanism of such influence. For this reason, this paper studied the correlation between college students’ IS and EP. At first, the paper gave a theoretical framework for analyzing the said influence mechanism. Then, focusing on the synchronization of IS and EP, this paper used the entropy to measure the sync correlation between the two, so as to quantify the joint improvement speed of the two, and six quantitative indicators had been adopted in the paper, including multi-scale sample entropy, multi-scale fuzzy entropy, cross-sample entropy, transfer entropy, de-trend correlation coefficient, and temporal correlation. At last, relevant experiments were conducted and the analysis results of the correlation between the two were given.