Neighborhood-Based Socioeconomic Position and Risk of Oral Clefts Among Offspring

Lupo, Philip J.; Danysh, Heather E.; Symanski, Elaine; Langlois, Peter H.; Cai, Yi; Swartz, Michael D.

doi:10.2105/ajph.2015.302804

Cited by 27 publications

(40 citation statements)

References 35 publications

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“…Most of the studies were conducted in the United States or Canada (7 studies: [9,11,13,22,24,27,29]). There were also three studies conducted in Europe[25,26,28] and one in Argentina[23].…”

Section: Resultsmentioning

confidence: 99%

“…There were also three studies conducted in Europe[25,26,28] and one in Argentina[23]. With the exception of two ecological epidemiology studies[25,26], all analyzed individual data, with seven case-control study design papers[9,11,22–24,27,28] and two cohort studies[13,29] (Table 1). …”

Section: Resultsmentioning

confidence: 99%

“…Databases were drawn from specific registers[22,25,26,28], national birth defect prevention studies and monitoring programs [11,13,23,27,29] as well as from hospital reports and medical records[9,24] (Table 2). …”

Section: Resultsmentioning

confidence: 99%

“…focused on both conotruncal defects: Tetralogy Of Fallot (TOF) and dextro-Transposition of Great Arteries (dTGA)[9,27]. All studies that investigated OFCs studied CLP and CP, separately [9,22,23,25–28]. On the whole, CLP and CP subtypes seem to be the most investigated defect phenotype subtypes, followed by An and SB defects.…”

Section: Resultsmentioning

confidence: 99%

“…American studies used census tract and block level [9,11,22,24,27] as well as enumeration or dissemination area[13,29] whereas UK studies had information at the level of enumeration districts [28], postcode sector [26], or ward [25]. One study has recently used a wider level—the region—to explore the association between deprivation and specific defects such as SB, anencephaly, CP, CLP, ventricular septal defect and truncus arterious[23].…”

Section: Resultsmentioning

confidence: 99%

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Neighborhood Deprivation and Risk of Congenital Heart Defects, Neural Tube Defects and Orofacial Clefts: A Systematic Review and Meta-Analysis

et al. 2016

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BackgroundWe conducted this systematic review and meta-analysis to address the open question of a possible association between the socioeconomic level of the neighborhoods in which pregnant women live and the risk of Congenital Heart Defects (CHDs), Neural Tube Defects (NTDs) and OroFacial Clefts (OFCs).MethodsWe searched MEDLINE from its inception to December 20th, 2015 for case-control, cohort and ecological studies assessing the association between neighborhood socioeconomic level and the risk of CHDs, NTDs and the specific phenotypes Cleft Lip with or without Cleft Palate (CLP) and Cleft Palate (CP). Study-specific risk estimates were pooled according to random-effect and fixed-effect models.ResultsOut of 245 references, a total of seven case-control studies, two cohort studies and two ecological studies were assessed in the systematic review; all studies were enrolled in the meta-analysis with the exception of the two cohort studies. No significant association has been revealed between CHDs or NTDs and neighborhood deprivation index. For CLP phenotype subgroups, we found a significantly higher rate in deprived neighborhoods (Odds Ratios (OR) = 1.22, 95% CI: 1.10, 1.36) whereas this was not significant for CP phenotype subgroups (OR = 1.20, 95%CI: 0.89, 1.61).ConclusionIn spite of the small number of epidemiological studies included in the present literature review, our findings suggest that neighborhood socioeconomic level where mothers live is associated only with an increased risk of CLP phenotype subgroups. This finding has methodological limitations that impede the formulation of firm conclusions, and further investigations should confirm this association.

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“…Most of the studies were conducted in the United States or Canada (7 studies: [9,11,13,22,24,27,29]). There were also three studies conducted in Europe[25,26,28] and one in Argentina[23].…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Neighborhood Deprivation and Risk of Congenital Heart Defects, Neural Tube Defects and Orofacial Clefts: A Systematic Review and Meta-Analysis

et al. 2016

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Are individual‐level risk factors for gastroschisis modified by neighborhood‐level socioeconomic factors?

Neo

Martin

Carmichael

et al. 2023

Birth Defects Research

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BackgroundTwo strong risk factors for gastroschisis are young maternal age (<20 years) and low/normal pre‐pregnancy body mass index (BMI), yet the reasons remain unknown. We explored whether neighborhood‐level socioeconomic position (nSEP) during pregnancy modified these associations.MethodsWe analyzed data from 1269 gastroschisis cases and 10,217 controls in the National Birth Defects Prevention Study (1997–2011). To characterize nSEP, we applied the neighborhood deprivation index and used generalized estimating equations to calculate odds ratios and relative excess risk due to interaction.ResultsElevated odds of gastroschisis were consistently associated with young maternal age and low/normal BMI, regardless of nSEP. High‐deprivation neighborhoods modified the association with young maternal age. Infants of young mothers in high‐deprivation areas had lower odds of gastroschisis (adjusted odds ratio [aOR]: 3.1, 95% confidence interval [CI]: 2.6, 3.8) than young mothers in low‐deprivation areas (aOR: 6.6; 95% CI: 4.6, 9.4). Mothers of low/normal BMI had approximately twice the odds of having an infant with gastroschisis compared to mothers with overweight/obese BMI, regardless of nSEP (aOR range: 1.5–2.3).ConclusionOur findings suggest nSEP modified the association between gastroschisis and maternal age, but not BMI. Further research could clarify whether the modification is due to unidentified biologic and/or non‐biologic factors.

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Is gastroschisis associated with county‐level socio‐environmental quality during pregnancy?

Krajewski,

Patel,

Gray

et al. 2023

Birth Defects Research

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BackgroundGastroschisis prevalence more than doubled between 1995 and 2012. While there are individual‐level risk factors (e.g., young maternal age, low body mass index), the impact of environmental exposures is not well understood.MethodsWe used the U.S. Environmental Protection Agency's Environmental Quality Index (EQI) as a county‐level estimate of cumulative environmental exposures for five domains (air, water, land, sociodemographic, and built) and overall from 2006 to 2010. Adjusted odds ratios (aOR) and 95% confidence interval (CI) were estimated from logistic regression models between EQI tertiles (better environmental quality (reference); mid; poorer) and gastroschisis in the National Birth Defects Prevention Study from births delivered between 2006 and 2011. Our analysis included 594 cases with gastroschisis and 4105 infants without a birth defect (controls).ResultsOverall EQI was modestly associated with gastroschisis (aOR [95% CI]: 1.29 [0.98, 1.71]) for maternal residence in counties with poorer environmental quality, compared to the reference (better environmental quality). Within domain‐specific indices, only the sociodemographic domain (aOR: 1.51 [0.99, 2.29]) was modestly associated with gastroschisis, when comparing poorer to better environmental quality.ConclusionsFuture work could elucidate pathway(s) by which components of the sociodemographic domain or possibly related psychosocial factors like chronic stress potentially contribute to risk of gastroschisis.

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Neighborhood-Based Socioeconomic Position and Risk of Oral Clefts Among Offspring

Abstract: Using data from one of the world's largest active surveillance birth defects registries, we found that adverse neighborhood SEP is modestly associated with CL±P, especially among Hispanics. These findings may have important implications for health disparities prevention.

Cited by 27 publications

References 35 publications

Neighborhood Deprivation and Risk of Congenital Heart Defects, Neural Tube Defects and Orofacial Clefts: A Systematic Review and Meta-Analysis

Neighborhood Deprivation and Risk of Congenital Heart Defects, Neural Tube Defects and Orofacial Clefts: A Systematic Review and Meta-Analysis

Are individual‐level risk factors for gastroschisis modified by neighborhood‐level socioeconomic factors?

Is gastroschisis associated with county‐level socio‐environmental quality during pregnancy?

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