Neighborhood-Level Disadvantage Impacts on Patients with Fibrotic Interstitial Lung Disease

Goobie, G.C.; Ryerson, Christopher J.; Johannson, Kerri A.; Schikowski, Erin; Zou, Richard H; Khalil, Nasreen; Marcoux, V.; Assayag, Deborah; Manganas, H.; Fisher, J.H.; Kolb, Martin; Gibson, Kevin F.; Kass, Daniel J.; Zhang, Yingze; Lindell, Kathleen O.; Nouraie, Mehdi

doi:10.1164/rccm.202109-2065oc

Cited by 30 publications

(23 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our study adds to a growing body of literature that suggests that social disadvantage is associated with meaningful clinical consequences in patients with IPF ( 15 – 17 ). Consistent with our finding of an association between median zip code income and lung transplant, a recent study found a lower odds of lung transplant in patients with IPF who had greater neighborhood-level disadvantage ( 18 ). This suggests that although zip code areas can be large and heterogeneous, zip code–level median income may still be a reliable measure of neighborhood or individual socioeconomic status within certain regions ( 19 ).…”

Section: Discussionsupporting

confidence: 91%

Disparities in Lung Transplant among Patients with Idiopathic Pulmonary Fibrosis: An Analysis of the IPF-PRO Registry

et al. 2022

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 91%

Disparities in Lung Transplant among Patients with Idiopathic Pulmonary Fibrosis: An Analysis of the IPF-PRO Registry

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The MLHCs were designed to target populations in areas of high social deprivation at higher risk of lung cancer and in whom access to health services is low [ 13 ]. This is also an important issue in fibrotic lung disease, in which reduced socioeconomic status has been associated with reduced survival [ 24 , 25 ]. The reasons for this are likely to be multifactorial, but may include increased exposure to atmospheric air pollution [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

The detection, assessment and clinical evolution of interstitial lung abnormalities identified through lung cancer screening

et al. 2023

View full text Add to dashboard Cite

IntroductionInterstitial lung abnormalities (ILAs) are common incidental findings in lung cancer screening however their clinical evolution and longer-term outcomes are less clear. The aim of this cohort study was to report five-year outcomes of individuals with ILA identified through a lung cancer screening programme. In addition, we compared patient reported outcome measures (PROMs) in patients with screen-detected ILA to newly diagnosed interstitial lung disease (ILD) to assess symptoms and health-related quality of life (HRQOL).MethodsIndividuals with screen-detected ILA were identified and five-year outcomes, including ILD diagnoses, progression-free survival and mortality, were recorded. Risk factors associated with ILD diagnosis were assessed using logistic regression and survival using Cox proportional hazard analysis. PROMs were compared between a subset of patients with ILA and a group of ILD patients.Results1,384 individuals underwent baseline low-dose computed tomography (LDCT) screening with 54 (3.9%) identified as having ILA. 22 (40.7%) were subsequently diagnosed with ILD. 14 individuals (25.9%) died, and 28 (53.8%) suffered disease progression within five years. Fibrotic ILA was an independent risk factor for ILD diagnosis, mortality, and reduced progression-free survival. Patients with ILA had lower symptom burden and better HRQOL in comparison to the ILD group. Breathlessness visual analogue score (VAS) was associated with mortality on multivariate analysis.ConclusionsFibrotic ILA was a significant risk factor for adverse outcomes including subsequent ILD diagnosis. Whilst screen-detected ILA patients were less symptomatic, breathlessness VAS was associated with adverse outcomes. These results could inform risk stratification in ILA.

show abstract

“…These studies, however, examine cohorts of waitlisted patients and, hence, do not reflect disparities in transplant referral, eligibility, or listing. In contrast, Goobie and colleagues recently identified a socioeconomic gap in lung transplantation among a more general cohort of IPF patients at one U.S. registry site but did not find such a gap in a Canadian cohort ( 8 ). In another registry-based study, Ramos and colleagues found that patients with cystic fibrosis in the United States had a higher risk of death and a lower risk of transplant relative to those in Canada, a difference driven by low rates of transplantation among patients with cystic fibrosis in the United States with public insurance; they also observed racial disparities in transplantation ( 9 ).…”

mentioning

confidence: 93%

Lung Transplantation Disparities among Patients with IPF: Recognition and Remedy

Gaffney

2022

Annals ATS

View full text Add to dashboard Cite

Neighborhood-Level Disadvantage Impacts on Patients with Fibrotic Interstitial Lung Disease

Cited by 30 publications

References 28 publications

Disparities in Lung Transplant among Patients with Idiopathic Pulmonary Fibrosis: An Analysis of the IPF-PRO Registry

Disparities in Lung Transplant among Patients with Idiopathic Pulmonary Fibrosis: An Analysis of the IPF-PRO Registry

The detection, assessment and clinical evolution of interstitial lung abnormalities identified through lung cancer screening

Lung Transplantation Disparities among Patients with IPF: Recognition and Remedy

Contact Info

Product

Resources

About