Neighborhood Socioeconomic Deprivation in Early Childhood Mediates Racial Disparities in Blood Pressure in a College Student Sample

Nichols, Olivia I.; Fuller‐Rowell, Thomas E.; Robinson, Austin T.; Eugene, DaJuandra; Homandberg, Lydia K.

doi:10.1007/s10964-022-01658-6

Cited by 6 publications

(9 citation statements)

References 85 publications

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“…Additional details of the parent study conducted from September 2018 to April 2019, have been described elsewhere. 15,24,26 Participant ages ranged from 20-23 years old. Exclusion criteria included: individual history of cancer, diabetes, or any chronic disease; signs, or symptoms of disease (i.e., history of chest pain, dizziness, unusual shortness of breath, etc.…”

Section: Methodsmentioning

confidence: 99%

“…These Census survey years were chosen so that data for our sample, collected in 2018-2019 with an average age of 19 years at the time, closely corresponded to the three developmental periods. 15,24 The ADI is a composite measure of neighborhood socioeconomic disadvantage composed of 17 poverty, education, housing, and employment census-tract indicators and has been previously used to track neighborhood-level disparities. 40 Each indicator was independently weighed by factor scores to ensure poverty, income, and education had the largest relative weights.…”

Section: Methodsmentioning

confidence: 99%

“…40 Each indicator was independently weighed by factor scores to ensure poverty, income, and education had the largest relative weights. Similar to prior studies, 15,24 the composite score was standardized to have a mean of 100 and a standard deviation (SD) of 20 to assist interpretation. Importantly, ADI is a validated approach for comprehensively assessing neighborhood deprivation.…”

Section: Methodsmentioning

confidence: 99%

“…21 Black Americans exhibit an increased risk for elevated nighttime BP and attenuated nighttime BP dipping, 22 a phenomenon that may begin at an early age. 23 Our prior data indicate there are racial disparities in clinic BP in young adults, 24–26 and neighborhood deprivation is a significant mediator. 24 However, relations between SDoH (i.e., neighborhood deprivation) and health behaviors with ambulatory BP are understudied.…”

Section: Introductionmentioning

confidence: 95%

“…23 Our prior data indicate there are racial disparities in clinic BP in young adults, 24–26 and neighborhood deprivation is a significant mediator. 24 However, relations between SDoH (i.e., neighborhood deprivation) and health behaviors with ambulatory BP are understudied.…”

Section: Introductionmentioning

confidence: 95%

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Interplay of Race and Neighborhood Deprivation on Ambulatory Blood Pressure in Young Adults

Jeong,

Linder,

Barnett

et al. 2023

Preprint

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BackgroundAmbulatory blood pressure (BP) monitoring measures nighttime BP and BP dipping, which are superior to in-clinic BP for predicting cardiovascular disease (CVD), the leading cause of death in America. Compared with other racial/ethnic groups, Black Americans exhibit elevated nighttime BP and attenuated BP dipping, including in young adulthood. Social determinants of health contribute to disparities in CVD risk, but the contribution of neighborhood deprivation on nighttime BP is unclear. Therefore, we examined associations between neighborhood deprivation with nighttime BP and BP dipping in young Black and White adults.MethodsWe recruited 21 Black and 26 White participants (20 M/27 F, mean age: 21 years, body mass index: 25±4 kg/m2) for 24-hour ambulatory BP monitoring. We assessed nighttime BP and BP dipping (nighttime:daytime BP ratio). The area deprivation index (ADI) was used to measure neighborhood deprivation. Associations between ADI and ambulatory BP were examined.ResultsBlack participants exhibited higher nighttime diastolic BP compared with White participants (63±8 mmHg vs 58±7 mmHg,p=0.003), and attenuated BP dipping ratios for both systolic (0.92±0.06 vs 0.86±0.05,p=0.001) and diastolic BP (0.86±0.09 vs 0.78±0.08,p=0.007). Black participants experienced greater neighborhood deprivation compared with White participants (ADI scores: 110±8 vs 97±21,p<0.001), and ADI was associated with attenuated systolic BP dipping (ρ=0.342,p=0.019).ConclusionsOur findings suggest neighborhood deprivation may contribute to higher nighttime BP and attenuated BP dipping, which are prognostic of CVD, and more prevalent in Black adults. Targeted interventions to mitigate the effects of neighborhood deprivation may help to improve nighttime BP.Clinical Trial RegistryURL:https://www.clinicaltrials.gov; Unique identifier:NCT04576338Clinical PerspectiveWe demonstrate young Black adults exhibit higher nighttime blood pressure and attenuated nighttime blood pressure dipping compared with young White adults.Black adults were exposed to greater neighborhood deprivation, which was associated with attenuated blood pressure dipping, irrespective of race.Our findings add to a growing body of literature indicating neighborhood deprivation may contribute to increased cardiovascular disease risk.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 95%

See 3 more Smart Citations

Interplay of Race and Neighborhood Deprivation on Ambulatory Blood Pressure in Young Adults

Jeong,

Linder,

Barnett

et al. 2023

Preprint

Self Cite

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Urinary Proteomics and Systems Biology Link Eight Proteins to the Higher Risk of Hypertension and Related Complications in Blacks Versus Whites

An,

Martens,

Mokwatsi

et al. 2024

Proteomics

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Blacks are more prone to salt‐sensitive hypertension than Whites. This cross‐sectional analysis of a multi‐ethnic cohort aimed to search for proteins potentially involved in the susceptibility to salt sensitivity, hypertension, and hypertension‐related complications. The study included individuals enrolled in African Prospective Study on the Early Detection and Identification of Cardiovascular Disease and Hypertension (African‐PREDICT), Flemish Study of the Environment, Genes and Health Outcomes (FLEMENGHO), Prospective Cohort Study in Patients with Type 2 Diabetes Mellitus for Validation of Biomarkers (PROVALID)‐Austria, and Urinary Proteomics Combined with Home Blood Pressure Telemonitoring for Health Care Reform Trial (UPRIGHT‐HTM). Sequenced urinary peptides detectable in 70% of participants allowed the identification of parental proteins and were compared between Blacks and Whites. Of 513 urinary peptides, 300 had significantly different levels among healthy Black (n = 476) and White (n = 483) South Africans sharing the same environment. Analyses contrasting 582 Blacks versus 1731 Whites, and Sub‐Saharan Blacks versus European Whites replicated the findings. COL4A1, COL4A2, FGA, PROC, MGP, MYOCD, FYXD2, and UMOD were identified as the most likely candidates underlying the racially different susceptibility to salt sensitivity, hypertension, and related complications. Enriched pathways included hemostasis, platelet activity, collagens, biology of the extracellular matrix, and protein digestion and absorption. Our study suggests that MGP and MYOCD being involved in cardiovascular function, FGA and PROC in coagulation, FYXD2 and UMOD in salt homeostasis, and COL4A1 and COL4A2 as major components of the glomerular basement membrane are among the many proteins potentially incriminated in the higher susceptibility of Blacks compared to Whites to salt sensitivity, hypertension, and its complication. Nevertheless, these eight proteins and their associated pathways deserve further exploration in molecular and human studies as potential targets for intervention to reduce the excess risk of hypertension and cardiovascular complications in Blacks versus Whites.

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Racial-ethnic disparities in childhood hypertension

Hanevold

2022

Pediatr Nephrol

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Neighborhood Socioeconomic Deprivation in Early Childhood Mediates Racial Disparities in Blood Pressure in a College Student Sample

Cited by 6 publications

References 85 publications

Interplay of Race and Neighborhood Deprivation on Ambulatory Blood Pressure in Young Adults

Interplay of Race and Neighborhood Deprivation on Ambulatory Blood Pressure in Young Adults

Urinary Proteomics and Systems Biology Link Eight Proteins to the Higher Risk of Hypertension and Related Complications in Blacks Versus Whites

Racial-ethnic disparities in childhood hypertension

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