Neighbourhood-level air pollution and greenspace and inflammation in adults

Midouhas, Emily; Kokosi, Theodora; Flouri, Eirini

doi:10.1016/j.healthplace.2019.102167

Cited by 12 publications

(12 citation statements)

References 43 publications

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“…The limited literature on greenspace- and health-focused studies in the US might be due to less funding on the topic, which currently tends to require additional factors such as air pollution, to be funded. Ironically, air pollution is a significant predictor of inflammation [ 152 ], and greenspace is a significant contributor to reducing air pollution in urban settings [ 153 ], which suggests the need for adding a focus on greenspace in inflammation and urban health studies. This pathway could be leveraged in studying greenspace in the US to reduce inflammation and improve cancer survivorship and survival.…”

Section: Greenspace Interventionsmentioning

confidence: 99%

Greenspace, Inflammation, Cardiovascular Health, and Cancer: A Review and Conceptual Framework for Greenspace in Cardio-Oncology Research

Bikomeye

Beyer

Kwarteng

et al. 2022

IJERPH

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Cardiovascular disease (CVD) is a leading cause of global morbidity and mortality. Cancer survivors have significantly elevated risk of poor cardiovascular (CV) health outcomes due to close co-morbid linkages and shared risk factors between CVD and cancer, as well as adverse effects of cancer treatment-related cardiotoxicity. CVD and cancer-related outcomes are exacerbated by increased risk of inflammation. Results from different pharmacological interventions aimed at reducing inflammation and risk of major adverse cardiovascular events (MACEs) have been largely mixed to date. Greenspaces have been shown to reduce inflammation and have been associated with CV health benefits, including reduced CVD behavioral risk factors and overall improvement in CV outcomes. Greenspace may, thus, serve to alleviate the CVD burden among cancer survivors. To understand pathways through which greenspace can prevent or reduce adverse CV outcomes among cancer survivors, we review the state of knowledge on associations among inflammation, CVD, cancer, and existing pharmacological interventions. We then discuss greenspace benefits for CV health from ecological to multilevel studies and a few existing experimental studies. Furthermore, we review the relationship between greenspace and inflammation, and we highlight forest bathing in Asian-based studies while presenting existing research gaps in the US literature. Then, we use the socioecological model of health to present an expanded conceptual framework to help fill this US literature gap. Lastly, we present a way forward, including implications for translational science and a brief discussion on necessities for virtual nature and/or exposure to nature images due to the increasing human–nature disconnect; we also offer guidance for greenspace research in cardio-oncology to improve CV health outcomes among cancer survivors.

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Section: Greenspace Interventionsmentioning

confidence: 99%

Greenspace, Inflammation, Cardiovascular Health, and Cancer: A Review and Conceptual Framework for Greenspace in Cardio-Oncology Research

Bikomeye

Beyer

Kwarteng

et al. 2022

IJERPH

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“…These associations, however, have been less consistent in the case of nitrogen dioxide. Multiple studies from European countries, as well as one study from the US and another one from Taiwan, failed to demonstrate any substantial links between levels of ambient NO 2 and serum CRP levels [24,26,27,40,[47][48][49][50][51][52]. On the contrary, an analysis of two large European cohorts involving 51,459 participants found a 1.9% increase in hs-CRP in association with a 7.4 µg/m 3 increment in NO 2 exposure [53].…”

Section: Discussionmentioning

confidence: 99%

Systemic Inflammation (C-Reactive Protein) in Older Chinese Adults Is Associated with Long-Term Exposure to Ambient Air Pollution

Elbarbary

Oganesyan

Honda

et al. 2021

IJERPH

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There is an established association between air pollution and cardiovascular disease (CVD), which is likely to be mediated by systemic inflammation. The present study evaluated links between long-term exposure to ambient air pollution and high-sensitivity C reactive protein (hs-CRP) in an older Chinese adult cohort (n = 7915) enrolled in the World Health Organization (WHO) study on global aging and adult health (SAGE) China Wave 1 in 2008–2010. Multilevel linear and logistic regression models were used to assess the associations of particulate matter (PM) and nitrogen dioxide (NO2) on log-transformed hs-CRP levels and odds ratios of CVD risk derived from CRP levels adjusted for confounders. A satellite-based spatial statistical model was applied to estimate the average community exposure to outdoor air pollutants (PM with an aerodynamic diameter of 10 μm or less (PM10), 2.5 μm or less (PM2.5), and 1 μm or less (PM1) and NO2) for each participant of the study. hs-CRP levels were drawn from dried blood spots of each participant. Each 10 μg/m3 increment in PM10, PM2.5, PM1, and NO2 was associated with 12.8% (95% confidence interval; (CI): 9.1, 16.6), 15.7% (95% CI: 10.9, 20.8), 10.2% (95% CI: 7.3, 13.2), and 11.8% (95% CI: 7.9, 15.8) higher serum levels of hs-CRP, respectively. Our findings suggest that air pollution may be an important factor in increasing systemic inflammation in older Chinese adults.

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“…18,19 Greenspace can also partially attenuate the detrimental impacts of noise and air pollution. [20][21][22] However, these environmental exposures are not equally distributed among different populations, as minority and low-income individuals are more likely to reside in areas of greater noise, air pollution, ALAN, and lower levels of greenspace. [23][24][25] While some studies have evaluated environment or stress and adolescent sleep patterns separately, none have assessed them together.…”

Section: What This Study Addsmentioning

confidence: 99%

Disparities in greenspace associated with sleep duration among adolescent children in Southern California

Zhong,

Yin,

Fallah-Shorshani

et al. 2023

Environmental Epidemiology

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Background: More than half of adolescent children do not get the recommended 8 hours of sleep necessary for optimal growth and development. In adults, several studies have evaluated effects of urban stressors including lack of greenspace, air pollution, noise, nighttime light, and psychosocial stress on sleep duration. Little is known about these effects in adolescents, however, it is known that these exposures vary by socioeconomic status (SES). We evaluated the association between several environmental exposures and sleep in adolescent children in Southern California. Methods: In 2010, a total of 1476 Southern California Children’s Health Study (CHS) participants in grades 9 and 10 (mean age, 13.4 years; SD, 0.6) completed a questionnaire including topics on sleep and psychosocial stress. Exposures to greenspace, artificial light at night (ALAN), nighttime noise, and air pollution were estimated at each child’s residential address, and SES was characterized by maternal education. Odds ratios and 95% confidence intervals (95% CIs) for sleep outcomes were estimated by environmental exposure, adjusting for age, sex, race/ethnicity, home secondhand smoke, and SES. Results: An interquartile range (IQR) increase in greenspace decreased the odds of not sleeping at least 8 hours (odds ratio [OR], 0.86 [95% CI, 0.71, 1.05]). This association was significantly protective in low SES participants (OR, 0.77 [95% CI, 0.60, 0.98]) but not for those with high SES (OR, 1.16 [95%CI, 0.80, 1.70]), interaction P = 0.03. Stress mediated 18.4% of the association among low SES participants. Conclusions: Residing in urban neighborhoods of greater greenness was associated with improved sleep duration among children of low SES but not higher SES. These findings support the importance of widely reported disparities in exposure and access to greenspace in socioeconomically disadvantaged populations.

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Neighbourhood-level air pollution and greenspace and inflammation in adults

Cited by 12 publications

References 43 publications

Greenspace, Inflammation, Cardiovascular Health, and Cancer: A Review and Conceptual Framework for Greenspace in Cardio-Oncology Research

Greenspace, Inflammation, Cardiovascular Health, and Cancer: A Review and Conceptual Framework for Greenspace in Cardio-Oncology Research

Systemic Inflammation (C-Reactive Protein) in Older Chinese Adults Is Associated with Long-Term Exposure to Ambient Air Pollution

Disparities in greenspace associated with sleep duration among adolescent children in Southern California

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