2019
DOI: 10.26717/bjstr.2019.21.003530
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NEIL (Nucleotide Expression, Inspiration, and Logic): a new Computational Approach to the Analysis of MicroRNA-Related Nucleotide Variations

Abstract: Genetic variations of microRNAs and their target sites among individuals are increasingly recognized as possible factors underlying various human disorders. Currently, the computer-assisted predictions of microRNA-binding sites rely exclusively on one or few reference genomic sequences and do not take into consideration significant variations within human genomes. There is a need to develop computational approaches to assess the probability of excessively strong or completely disabled microRNA-binding sites up… Show more

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“…The computer-assisted prediction of microRNA-binding sites upon the reference genomic sequences does not reckon with the well-known by now genomic variation, which is characteristic of all biological species [1]. We developed the miRNA-mRNA complementarity alignment tool NEIL [2], and the more complex package called miRNAhrend [3] (https://franziskaahrend.pythonanywhere.com/). The latter one is the online-available package for the prediction and visualization of the miRNA-binding sites in any RNA sequence with their following verification by the complementarity alignment.…”
Section: Introductionmentioning
confidence: 99%
“…The computer-assisted prediction of microRNA-binding sites upon the reference genomic sequences does not reckon with the well-known by now genomic variation, which is characteristic of all biological species [1]. We developed the miRNA-mRNA complementarity alignment tool NEIL [2], and the more complex package called miRNAhrend [3] (https://franziskaahrend.pythonanywhere.com/). The latter one is the online-available package for the prediction and visualization of the miRNA-binding sites in any RNA sequence with their following verification by the complementarity alignment.…”
Section: Introductionmentioning
confidence: 99%