Neisseria gonorrhoeae molecular typing for understanding sexual networks and antimicrobial resistance transmission: A systematic review

Town, Katy; Bolt, Hikaru; Croxford, Sara; Cole, Michelle; Harris, Simon R.; Field, Nigel; Hughes, Gwenda

doi:10.1016/j.jinf.2018.02.011

Cited by 16 publications

(11 citation statements)

References 57 publications

(269 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MSMW with gonorrhoea were scattered within MSM and heterosexual networks suggesting a possible role in bridging transmission between MSMO and females, although given our sampling frame, it is not possible to say whether these were responsible for the commencement of transmission clusters. Previous studies (predominantly using NG-MAST) have varied in the extent of bridging identified across heterosexual and MSM-associated networks 23 . For example, Choudhury et al found that MSM comprised only 1.7% of cases associated with the 14 major heterosexual NG-MAST groups in a large study from London in 2004 24 .…”

Section: Discussionmentioning

confidence: 99%

Bridging of Neisseria gonorrhoeae lineages across sexual networks in the HIV pre-exposure prophylaxis era

et al. 2019

View full text Add to dashboard Cite

Whole genome sequencing (WGS) has been used to investigate transmission of Neisseria gonorrhoeae , but to date, most studies have not combined genomic data with detailed information on sexual behaviour to define the extent of transmission across population risk groups (bridging). Here, through combined epidemiological and genomic analysis of 2,186 N. gonorrhoeae isolates from Australia, we show widespread transmission of N. gonorrhoeae within and between population groups. We describe distinct transmission clusters associated with men who have sex with men (MSM) and heterosexuals, and men who have sex with men and women (MSMW) are identified as a possible bridging population between these groups. Further, the study identifies transmission of N. gonorrhoeae between HIV-positive and HIV-negative individuals receiving pre-exposure prophylaxis (PrEP). Our data highlight several groups that can be targeted for interventions aimed at improving gonorrhoea control, including returning travellers, sex workers, and PrEP users.

show abstract

Section: Discussionmentioning

confidence: 99%

Bridging of Neisseria gonorrhoeae lineages across sexual networks in the HIV pre-exposure prophylaxis era

et al. 2019

View full text Add to dashboard Cite

show abstract

“…WGS also can contribute evidence toward the development of rapid antimicrobial susceptibility tests to improve treatment decisions (8,9). However, few N. gonorrhoeae WGS studies have been conducted in England, and none include representative geographic coverage over time (10)(11)(12)(13).…”

mentioning

confidence: 99%

Genomic and Phenotypic Variability in Neisseria gonorrhoeae Antimicrobial Susceptibility, England

Town¹,

Harris²,

Sánchez-Busó³

et al. 2020

Emerg. Infect. Dis.

Self Cite

View full text Add to dashboard Cite

“…[13][14][15][16][17][18][19][20][21] However, few studies have included sufficient clinical and sexual behaviour data to explore sexual mixing patterns between different sociodemographic groups and how mixing might influence STI and HIV transmission risk. 22 To inform public health infection control efforts, we wholegenome sequenced more than 1200 N gonorrhoeae isolates with linked clinical and sociodemographic data collected in five sexual health clinics in England over a 4year period. We investigated sexual mixing in N gonorrhoeae transmission networks between MSM, men reporting heterosexual behaviours, and women, and between MSM with and without HIV.…”

Section: Introductionmentioning

confidence: 99%

Phylogenomic analysis of Neisseria gonorrhoeae transmission to assess sexual mixing and HIV transmission risk in England: a cross-sectional, observational, whole-genome sequencing study

Town

Field

Harris³

et al. 2020

The Lancet Infectious Diseases

Self Cite

View full text Add to dashboard Cite

Background Characterising sexual networks with transmission of sexually transmitted infections might allow identification of individuals at increased risk of infection. We aimed to investigate sexual mixing in Neisseria gonorrhoeae transmission networks between women, heterosexual men, and men who report sex with men (MSM), and between people with and without HIV. MethodsIn this cross-sectional observational study, we whole-genome sequenced N gonorrhoeae isolates from the archive of the Gonococcal Resistance to Antimicrobials Surveillance Programme (GRASP).w Isolates that varied by five single nucleotide polymorphisms or fewer were grouped into clusters that represented sexual networks with N gonorrhoeae transmission. Clusters were described by gender, sexual risk group, and HIV status. Findings We sequenced 1277 N gonorrhoeae isolates with linked clinical and sociodemographic data that were collected in five clinics in England during 2013-16 (July 1 to Sept 30 in 2013-15; July 1 to Sept 9 in 2016). The isolates grouped into 213 clusters. 30 (14%) clusters contained isolates from heterosexual men and MSM but no women and three (1%) clusters contained isolates from only women and MSM. 146 (69%) clusters comprised solely people with negative or unknown HIV status and seven (3%) comprised only HIV-positive people. 60 (28%) clusters comprised MSM with positive and negative or unknown HIV status.Interpretation N gonorrhoeae molecular data can provide information indicating risk of HIV or other sexually transmitted infections for some individuals for whom such risk might not be known from clinical history. These findings have implications for sexual health care, including offering testing, prevention advice, and preventive treatment, such as HIV pre-exposure prophylaxis.

show abstract

Neisseria gonorrhoeae molecular typing for understanding sexual networks and antimicrobial resistance transmission: A systematic review

Cited by 16 publications

References 57 publications

Bridging of Neisseria gonorrhoeae lineages across sexual networks in the HIV pre-exposure prophylaxis era

Bridging of Neisseria gonorrhoeae lineages across sexual networks in the HIV pre-exposure prophylaxis era

Genomic and Phenotypic Variability in Neisseria gonorrhoeae Antimicrobial Susceptibility, England

Phylogenomic analysis of Neisseria gonorrhoeae transmission to assess sexual mixing and HIV transmission risk in England: a cross-sectional, observational, whole-genome sequencing study

Contact Info

Product

Resources

About