Neisseria species as pathobionts in bronchiectasis.

Abstract

Highlights d Some bronchiectasis patients exhibit increased airway abundance of Neisseria spp. d The culturable species N. subflava weakens barrier integrity and induces inflammation d N. subflava elicits distinct transcriptomic/metabolipidomic signatures in the mouse lung d Neisseria-associated pathogenic signatures are observed in bronchiectasis patients Authors