2016
DOI: 10.1016/j.micinf.2016.06.001
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Neisseriae internalization by epithelial cells is enhanced by TLR2 stimulation

Abstract: N. meningitidis (NM) is an opportunistic gram-negative human pathogen that colonizes the human nasopharyngeal epithelium. Asymptomatic carriage is common, but some meningococcal strains can invade nasopharyngeal epithelial cells and proceed to cause severe and often fatal infections. Invasion is predominantly driven by expression of bacterial virulence factors and host cell cognate receptors for bacterial recognition. Porins are among the Neisserial components involved in host cell activation and bacterial int… Show more

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Cited by 11 publications
(8 citation statements)
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“…The concept of metabolically dormant and semi-dormant bacilli residing in host intracellular niches is not new. Neisseria meningitidis is known to be internalized by human airway epithelial cells through a mechanism also partly dependent on actin polymerization (Toussi et al, 2016). Mycobacteria tuberculosis survive and grow within macrophages, which provide a sanctuary protecting these bacteria from the bactericidal effects of some anti-tuberculous antibiotics (Jindani et al, 2003).…”
Section: Discussionmentioning
confidence: 99%
“…The concept of metabolically dormant and semi-dormant bacilli residing in host intracellular niches is not new. Neisseria meningitidis is known to be internalized by human airway epithelial cells through a mechanism also partly dependent on actin polymerization (Toussi et al, 2016). Mycobacteria tuberculosis survive and grow within macrophages, which provide a sanctuary protecting these bacteria from the bactericidal effects of some anti-tuberculous antibiotics (Jindani et al, 2003).…”
Section: Discussionmentioning
confidence: 99%
“…Receptor interactions in choroid epithelial cells in vitro result in an NFκB-mediated pro-inflammatory immune response involving the transcription factor IκBζ as well as regnase, a ribonuclease involved in posttranscriptional regulation of the inflammatory immune response [ 127 , 139 ]. NFκB-mediated as well as MAPK signaling involved in internalization has also been reported for bronchial epithelial cells [ 131 ].…”
Section: Neisserial Interactions With the Hostmentioning
confidence: 96%
“…Expression analysis of pattern recognition receptors (PRRs) reveals TLR2/TLR6 complex interactions with lipoprotein components of the bacterial cell wall more likely than TLR2/TLR1- or TLR4-mediated signaling. Neisseria internalization into epithelial cells in vitro also seems rather to involve TLR2/TLR1 than TLR4 signaling [ 131 ]. The PorB protein of Neisseria is considered as a TLR2/TLR6 ligand [ 132 ].…”
Section: Neisserial Interactions With the Hostmentioning
confidence: 99%
“…Similar to A␤ and ␣-synuclein, OTUB1 oligomers also alter the membrane nanostructure, as observed in AFM. The membrane damage by amyloid oligomers is presumably due to the electrostatic interaction between protein assembly and lipid surfaces, as observed in many antimicrobial peptides (77,78). Neuronal cells exposed to amyloid oligomers show a disrupted actin cytoskeletal network compared with monomer.…”
Section: Otub1 Is An Amyloidogenic Proteinmentioning
confidence: 99%