Neither cholelithiasis nor cholecystectomy is causally associated with colorectal cancer: A univariate and multivariate mendelian randomization study
Qiong Qin,
Yong Zhou,
Ao Ren
et al.
Abstract:Background
Epidemiological studies reported controversial results regarding the relationship between cholelithiasis, cholecystectomy and colorectal cancer (CRC). In the presence of reverse causality and confounding factors, findings of our previous retrospective study that it was gallbladder disease rather than cholecystectomy that was a risk factor for colorectal cancer was not sufficiently convincing. Therefore, we used Mendelian randomization (MR) to further explore the relationship between cholelithiasis … Show more
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