Neither perirhinal/entorhinal nor hippocampal lesions impair short-term auditory recognition memory in dogs

Kowalska, Danuta; Kuśmierek, Paweł; Kosmal, A; Mishkin, Mortimer

doi:10.1016/s0306-4522(01)00140-3

Cited by 37 publications

(36 citation statements)

References 44 publications

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“…This temporal profile suggests that perirhinal and other visual cortical regions can maintain visual memories accurately during intermediate spans and that the effects of perirhinal damage cannot be attributed solely to the disruption of signals going to and coming from the hippocampus. It also indicates that hippocampal deficits may be more difficult to detect in DMTS tasks that do not generate good, long delay performance (10,11,30).…”

Section: Discussionmentioning

confidence: 99%

“…The role of the hippocampus in this form of memory, on the other hand, cannot be as clearly inferred from existing data. For example, hippocampal damage in humans impairs performance on nonverbal recognition tasks, but the results in nonhuman primates are conflicting as to whether selective hippocampal damage impairs performance on visual recognition memory tasks (9)(10)(11)(12).…”

mentioning

confidence: 99%

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Visual memory task for rats reveals an essential role for hippocampus and perirhinal cortex

Prusky

Douglas

Nelson

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

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Visual recognition memory is subserved by a distributed set of neural circuits, which include structures of the temporal lobe. Conflicting experimental results regarding the role of the hippocampus in nonspatial forms of such memories have been attributed to species, task, and lesion discrepancies. We have overcome obstacles that have prevented a direct evaluation of the role of the hippocampus in this type of memory by developing for rats a nonspatial, picture-based, trial-unique, delayed matching-to-sample task that is a procedural analogue of standard visual recognition memory tasks used in primates. With this task, we demonstrate that rats have a visual memory profile, which is analogous to that in primates and depends on the function of perirhinal cortex. We also find that selective lesions of hippocampus impair delay-dependent visual memory with a profile different from that produced by damage to the perirhinal cortex. These data demonstrate that rats have a visual recognition memory system fundamentally similar to primates that depends on the function of the hippocampus.M ost theories of medial temporal lobe function are in agreement that the hippocampus and perirhinal cortex are important for learning and memory. The specific processes that depend on the hippocampus, however, have been the subject of intense debate: in general, agreement exists that hippocampal function is essential for spatial memory, but wide disagreement occurs on the role of the hippocampus in nonspatial, visual recognition memory, or more generally, in explicit or episodic memory (1-5).The hallmark of this type of memory is retrieval of specific information from a single event (or episode) (6, 7). Trial-unique, delayed, matching-to-sample (DMTS) and delayed, nonmatching-to-sample (DNMTS) tasks, in which the participant must choose between two or more items, one of which is an item seen only once previously, have become the standard for measuring recognition memory in humans and nonhuman primates. Studies in primates have clearly shown that damage to perirhinal cortex disrupts performance on these tasks (8). The role of the hippocampus in this form of memory, on the other hand, cannot be as clearly inferred from existing data. For example, hippocampal damage in humans impairs performance on nonverbal recognition tasks, but the results in nonhuman primates are conflicting as to whether selective hippocampal damage impairs performance on visual recognition memory tasks (9-12).Visual recognition memory tasks have had limited application in rodents, but in general, recognition memory has been found to be unaffected by hippocampal damage unless the memory task includes a spatial component (13)(14)(15). A striking example of the apparent spatial dependence of hippocampal function is found in a study by Dudchenko and colleagues (16), in which memory for places or odors was measured in DNMTS procedures. The memory for places, but not odors, was disrupted by selective damage to the hippocampus. Attempts to measure nonspatial visual recognitio...

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Visual memory task for rats reveals an essential role for hippocampus and perirhinal cortex

Prusky

Douglas

Nelson

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

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“…In addition, diminished performance on tactual (Buffalo et al 1999) and olfactory recognition memory tasks has been reported in animals lacking perirhinal cortex (Otto and Eichenbaum 1992). However, auditory recognition memory is not affected by lesions of the perirhinal cortex (Kowalska et al 2001).…”

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confidence: 99%

Perirhinal Cortex Muscarinic Receptor Blockade Impairs Taste Recognition Memory Formation

Gutiérrez¹,

Cruz²,

Rodriguez‐Ortiz³

et al. 2004

Learn. Mem.

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The relevance of perirhinal cortical cholinergic and glutamatergic neurotransmission for taste recognition memory and learned taste aversion was assessed by microinfusions of muscarinic (scopolamine), NMDA (AP-5), and AMPA (NBQX) receptor antagonists. Infusions of scopolamine, but not AP5 or NBQX, prevented the consolidation of taste recognition memory using attenuation of neophobia as an index. In addition, learned taste aversion in both shortand long-term memory tests was exclusively impaired by scopolamine. These data provide neurochemical support for the theory that cholinergic activity of the perirhinal cortex participates in the formation of the taste memory trace and that it is independent of the NMDA and AMPA receptor activity. These results support the idea that cholinergic neurotransmission in the perirhinal cortex is also essential for acquisition and consolidation of taste recognition memory.

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“…Studies in monkeys (Saunders et al 1997) and dogs (Kowalska et al 2001) suggested that lesions limited to the perirhinal and entorhinal cortex of the medial temporal lobe spare auditory recognition memory. This finding may be understandable in the light of the neuroanatomy of auditory processing.…”

Section: Auditory Recognition In Amnesiamentioning

confidence: 99%

“…This pattern of results has been observed repeatedly in studies of recognition memory in monkeys, in which the deficit associated with restricted hippocampal lesions is exacerbated by additional damage to adjacent cortex (ZolaMorgan et al 1994). Similarly, in studies of human amnesia, large medial temporal lobe lesions consistently produce a more severe recognition memory impairment than restricted hippocampal lesions (Hamann and Squire 1997; Buffalo et al 1998;Stark and Squire 2000).Studies in monkeys (Saunders et al 1997) and dogs (Kowalska et al 2001) suggested that lesions limited to the perirhinal and entorhinal cortex of the medial temporal lobe spare auditory recognition memory. This finding may be understandable in the light of the neuroanatomy of auditory processing.…”

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confidence: 96%

Impaired Auditory Recognition Memory in Amnesic Patients with Medial Temporal Lobe Lesions

Squire

Schmolck²,

Stark³

2001

Learn. Mem.

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Two tests of auditory recognition memory were given to four patients with bilateral hippocampal damage (H+) and three patients with large medial temporal lobe lesions and additional variable damage to lateral temporal cortex (MTL+). When single stimuli were presented, performance was normal across delays as long as 30 sec, presumably because information could be maintained in working memory through rehearsal. When lists of 10 stimuli were presented, performance was impaired after a 5-min delay. Patients with MTL+ lesions performed marginally worse than patients with H+ lesions, consistent with findings for recognition memory in other modalities. The findings show that auditory recognition, like recognition memory in other sensory modalities, is dependent on the medial temporal lobe.Bilateral medial temporal lobe lesions in humans produce severe, multimodal memory impairment (Scoville and Milner 1957;Stefanacci et al. 2000). In one study, the noted patient H.M. failed tests of recognition memory when either visual stimuli (shades of red, lights flashes, or nonsense patterns) or auditory stimuli (tones or clicks) were presented, and delays of 60 sec were interposed between study and test (Milner 1972). After the development of one-trial tests of recognition memory for the monkey (Gaffan 1974;Mishkin and Delacour 1975), impaired recognition memory after medial temporal lobe lesions has been observed in the visual (Mishkin 1978;Zola-Morgan et al. 1982) and tactile (Murray and Mishkin 1984;Suzuki et al. 1993) modalities. Impaired recognition memory also has been observed in rats in the visual and olfactory modalities, when tests were given that were similar to those used with the monkey (Clark et al. 2000(Clark et al. , 2001Otto and Eichenbaum 1992).Aside from early studies of patient H.M., the effects of medial temporal lobe lesions on auditory recognition memory have not been well studied. Patients with left or right unilateral temporal lobe excisions, which included the amygdala, temporal pole, anterior neocortex, and variable extents of hippocampus and parahippocampal gyrus, were impaired at recognizing novel melodies (Samson and Zatorre 1992). However, it is unclear to what extent this impairment depended on damage specifically to the medial temporal lobe.Preliminary studies in the monkey suggested that large medial temporal lobe lesions do impair auditory recognition memory (Fritz et al. 1999). However, smaller lesions limited to perirhinal and entorhinal cortex had little effect (Saunders et al. 1998), in sharp contrast with the deficit in both visual and tactile recognition memory that is found in monkeys after perirhinal and entorhinal lesions (Meunier et al. 1993;Buffalo et al. 1999) . In addition, studies of auditory recognition memory have been conducted in dogs, with delays of up to 90 sec (Kowalskaet al. 2001). Neither lesions of the hippocampus (H), lesions of perirhinal and entorhinal cortex (Rh), nor combined lesions (H + Rh) had a detectable effect on performance. These findings raise questions abou...

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Neither perirhinal/entorhinal nor hippocampal lesions impair short-term auditory recognition memory in dogs

Cited by 37 publications

References 44 publications

Visual memory task for rats reveals an essential role for hippocampus and perirhinal cortex

Visual memory task for rats reveals an essential role for hippocampus and perirhinal cortex

Perirhinal Cortex Muscarinic Receptor Blockade Impairs Taste Recognition Memory Formation

Impaired Auditory Recognition Memory in Amnesic Patients with Medial Temporal Lobe Lesions

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