Neither physical exercise nor α1- and β-adrenergic blockade affect plasma endothelin concentrations

Cosenzi, Alessandro; Sacerdote, A; Bocin, Elena; Molino, Rossella; Plazzotta, N.; Seculin, Paolo; Bellini, Giuseppe

doi:10.1016/0895-7061(96)00019-2

Cited by 16 publications

(8 citation statements)

References 25 publications

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“…The finding in the present study of decreased plasma ET-1 levels after cycling is in agreement with the data of Richter et al [9], whereas others reported no change [19][20][21][22] or even an increase in ET-1 plasma concentrations in young athletes performing 30 min of strenuous cycling [8]. These discrepancies may be due to the small numbers of subjects investigated [21] or to differences in the protocols used, e.g., intensity of exercise [8], time of blood sampling after performance [20], or assays used for ET measurements [20,21].…”

Section: Discussionsupporting

confidence: 95%

Endothelin-1 concentration in plasma is increased after jogging but decreased after cycling in healthy men

Lewczuk

Kele

Reimers

et al. 2003

Clinical and Experimental Medicine

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Endothelin-1 plays an important role as a paracrine factor in the regulation of regional blood flow. Plasma levels may represent the net result of spill-over from local stimulation/release and elimination of endothelin-1. In order to compare changes in the concentration of endothelin-1 in the plasma of subjects performing different types of sports exercises we measured immunoreactive endothelin-1 in healthy volunteers ( n=20) performing in random order jogging on a treadmill and cycling on a bicycle ergometer, for 30 min each. Plasma immunoreactive endothelin-1 increased significantly after jogging (2.13+/-0.8 pg/ml versus 2.6+/-0.8 pg/ml, before and after exercise, respectively, P<0.03), whereas it decreased after cycling (2.45+/-0.76 pg/ml versus 2.25+/-0.9 pg/ml, before and after exercise, respectively, P<0.03). We suggest that microtraumatizing effects on the endothelial lining are more pronounced during jogging than during cycling, resulting in a greater increase in plasma endothelin-1, which is too high to be immediately eliminated by the lung despite exercise-induced enhanced pulmonary perfusion. In contrast, similarly enhanced lung perfusion together with a relatively lower stimulation of endothelin-1 compared with jogging, may explain the net decrease in plasma after cycling.

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Section: Discussionsupporting

confidence: 95%

Endothelin-1 concentration in plasma is increased after jogging but decreased after cycling in healthy men

Lewczuk

Kele

Reimers

et al. 2003

Clinical and Experimental Medicine

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“…The exercise-induced increases in plasma ET-1 obtained in our study confirm other reports [3,4] but are not in agreement with the results of Cosenzi et al [22] who showed unchanged ET-1 concentrations after dynamic exercise in normotensive subjects. These discrepant results may be due, at least in part, to the different stimulation induced by isometric and ergometric exercises, and to the assay methods used in the studies.…”

Section: Discussioncontrasting

confidence: 65%

Influence of Vascular Load on Plasma Endothelin-1, Cytokines and Catecholamine Levels in Essential Hypertensives

COTTONE

1998

Blood Pressure

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In vitro studies demonstrated a relationship between ET-1 and basic Fibroblast Growth Factor (bFGF), and of bFGF with Platelet Derived Growth Factor (PDGF). The present study was carried out to investigate in vivo the behaviour after vascular stress of circulating ET-1, bFGF and PDGF, and catecholamines, and their relationship. In 12 healthy normotensives (NTs) and 15 essential hypertensives (Ehs) venous blood samples to determine circulating ET-1, bFGF and PDGF, and catecholamine (EPI and NE) levels were drawn before and at the third minute of a handgrip test. Blood pressures (BP) and heart rate were automatically recorded before starting, and at 1, 2, and 3 minutes during the test. The NTs showed, in basal condition, lower values than the EHs of all the examined parameters; later, the handgrip test induced significant increases in circulating levels of ET-1, bFGF and catecholamine. In the EHs at the third minute of the exercise significant increases in plasma ET-1 (p < 0.002), bFGF (p < 0.006), and EPI and NE (p < 0.0005) levels were observed. Systolic and diastolic BP significantly increased after handgrip test in NTs and EHs. Plasma ET-1 correlated with bFGF both before (p < 0.01) and at the acme (p < 0.05) of the isometric exercise. Our results show that in EHs plasma ET-1 and bFGF correlate each other, indicating that in human hypertension a linkage between ET-1 and bFGF exists.

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“…Evidence for the ET-1 system as a potential regulator of exercising muscle blood flow has come largely from assays with evidence both for (29) and against (13,27) increased circulating ET-1 as a consequence of exercise. However, the preferential abluminal release of ET-1 and low endogenous concentration have led to the suggestion that systemic plasma ET-1 levels may not accurately reflect local ET-1 concentration (21,35).…”

Section: Discussionmentioning

confidence: 99%

Endothelin-1-mediated vasoconstriction at rest and during dynamic exercise in healthy humans

Wray

Nishiyama

Donato

et al. 2007

American Journal of Physiology-Heart and Circulatory Physiology

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It is now generally accepted that alpha-adrenoreceptor-mediated vasoconstriction is attenuated during exercise, but the efficacy of nonadrenergic vasoconstrictor pathways during exercise remains unclear. Thus, in eight young (23 +/- 1 yr), healthy volunteers, we contrasted changes in leg blood flow (ultrasound Doppler) before and during intra-arterial infusion of the alpha(1)-adrenoreceptor agonist phenylephrine (PE) with that of the nonadrenergic endothelin A (ET(A))/ET(B) receptor agonist ET-1. Heart rate, arterial blood pressure, common femoral artery diameter, and mean blood velocity were measured at rest and during knee-extensor exercise at 20%, 40%, and 60% of maximal work rate (WR(max)). Drug infusion rates were adjusted for blood flow to maintain comparable doses across all subjects and conditions. At rest, PE infusion (8 ng x ml(-1) x min(-1)) provoked a rapid and significant decrease in leg blood flow (-51 +/- 3%) within 2.5 min. Resting ET-1 infusion (40 pg x ml(-1) x min(-1)) significantly decreased leg blood flow within 5 min, reaching a maximal vasoconstriction (-34 +/- 3%) after 25-30 min of continuous infusion. Compared with rest, an exercise intensity-dependent attenuation to PE-mediated vasoconstriction was observed (-18 +/- 5%, -7 +/- 2%, and -1 +/- 3% change in leg blood flow at 20%, 40%, and 60% of WR(max), respectively). Vasoconstriction in response to ET-1 was also blunted in an exercise intensity-dependent manner (-13 +/- 3%, -7 +/- 4%, and 2 +/- 3% change in leg blood flow at 20%, 40%, and 60% of WR(max), respectively). These findings support a significant contribution of ET-1 and alpha-adrenergic receptors in the regulation of skeletal muscle blood flow in the human leg at rest and suggest a similar, intensity-dependent "lysis" of peripheral ET and alpha-adrenergic vasoconstriction during dynamic exercise.

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Neither physical exercise nor α1- and β-adrenergic blockade affect plasma endothelin concentrations

Cited by 16 publications

References 25 publications

Endothelin-1 concentration in plasma is increased after jogging but decreased after cycling in healthy men

Endothelin-1 concentration in plasma is increased after jogging but decreased after cycling in healthy men

Influence of Vascular Load on Plasma Endothelin-1, Cytokines and Catecholamine Levels in Essential Hypertensives

Endothelin-1-mediated vasoconstriction at rest and during dynamic exercise in healthy humans

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