Neither Preconceptional Weekly Multiple Micronutrient nor Iron–Folic Acid Supplements Affect Birth Size and Gestational Age Compared with a Folic Acid Supplement Alone in Rural Vietnamese Women: A Randomized Controlled Trial

Ramakrishnan, Usha; Nguyen, Phuong Hong; González-Casanova, Inés; Pham, Hoa; Wu, Hao; Nguyen, Hieu; Truong, Truong V; Nguyen, Son; Harding, Kimberly; Reinhart, Gregory A.; Neufeld, Lynnette M.; Martorell, Reynaldo

doi:10.3945/jn.115.223420

Cited by 48 publications

(69 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After testing positive for pregnancy, all of the women were given iron and folate daily until delivery. Preconception micronutrient supplementation did not alter fetal growth (22), but other outcomes are still under study.…”

Section: Periconception Nutrition Intervention Trials: Past and Ongoingmentioning

confidence: 92%

See 1 more Smart Citation

A Summary of Pathways or Mechanisms Linking Preconception Maternal Nutrition with Birth Outcomes

King¹

2016

The Journal of Nutrition

View full text Add to dashboard Cite

Population, human, animal, tissue, and molecular studies show collectively and consistently that maternal nutrition in the pre- or periconception period influences fetal growth and development, which subsequently affects the individual's long-term health. It is known that nutrition during pregnancy is an important determinant of the offspring's growth and health. However, now there is evidence that the mother's nutritional status at conception also influences pregnancy outcome and long-term health. For example, the mother's nutritional status at conception influences the way energy is partitioned between maternal and fetal needs. Furthermore, placental development during the first weeks of gestation reflects maternal nutrition and establishes mechanisms for balancing maternal and fetal nutritional needs. Also, maternal nutritional signals at fertilization influence epigenetic remodeling of fetal genes. These findings all indicate that maternal parenting begins before conception. The following papers from a symposium on preconception nutrition presented at the 2015 Scientific Sessions and Annual Meeting of the ASN emphasize the importance of maternal nutrition at conception on the growth and long-term health of the child.

show abstract

Section: Periconception Nutrition Intervention Trials: Past and Ongoingmentioning

confidence: 92%

“…Reproduced from reference 41 with permission. symposium, 2 other interventions were discussed-a nutrientrich snack provided to Indian women (16), and a micronutrient supplement intervention (22). Nutrition education is another option.…”

Section: Next Stepsmentioning

confidence: 99%

A Summary of Pathways or Mechanisms Linking Preconception Maternal Nutrition with Birth Outcomes

King¹

2016

The Journal of Nutrition

View full text Add to dashboard Cite

show abstract

“…Preconception underweight is associated with an increased risk of intrauterine growth retardation resulting in an SGA infant [20, 22]. Self-reported folic acid supplement during preconception, which aids fetal development, is associated with higher birthweight in children of underweight mothers [23, 24]. Adolescent pregnancies result in negative consequences for both the mother and infant.…”

Section: Linear Growth From Preconception To Beyond the First 1000 Dmentioning

confidence: 99%

World Perspective on the Epidemiology of Stunting between 1990 and 2015

2017

View full text Add to dashboard Cite

Background: Stunting is the most prevalent form of child undernutrition with current worldwide estimates at 156 million. The majority of these children reside in low- and middle-income countries. When stunting prevails to adulthood, optimal growth potential and economic productivity are minimized. Results: In 2015 there were 98.5 million fewer stunted children under 5 years of age than in 1990. In East Asia and Pacific and South Asia, the stunting prevalence decreased by 24.8 and 25%, respectively. Minimal declines were observed in Latin America and the Caribbean at 12.6%, in the Middle East and North Africa at 12.9%, and in sub-Saharan Africa at 13.4%. But because large populations of children under 5 years of age are distributed disproportionately, decreases in prevalence do not translate to fewer numbers of stunted children globally. In sub-Saharan Africa, the number of stunted children increased by 12.4 million between 1990 and 2015. Conclusions: Adult height is dependent on nutrition-specific or nutrition-sensitive factors. Nutrition-specific factors can be targeted according to their impact at critical points of development and therefore offer multiple windows of opportunity for interventions. To date, many interventions focus on the first 1,000 days, but opportunities may extend into later childhood and adolescence.

show abstract

“…We conducted a large double-blind randomized controlled trial of preconception micronutrient supplementation aiming to improve maternal health and birth outcomes (PRECONCEPT) [13, 14]. We have previously reported the findings from a qualitative study of beliefs and attitudes related to adherence to preconception and prenatal micronutrient supplementation that was conducted in a sub-sample of pre-pregnant, pregnant, and postpartum participants in the PRECONCEPT study [15], and found that women reported that they were more likely to adhere to supplements during pregnancy, as they considered them necessary for their and their offspring’s well-being.…”

Section: Introductionmentioning

confidence: 99%

Predictors of adherence to micronutrient supplementation before and during pregnancy in Vietnam

et al. 2017

Self Cite

View full text Add to dashboard Cite

BackgroundPoor adherence to micronutrient supplementation often limits the effectiveness of public health programs. While predictors of adherence to micronutrient supplementation during pregnancy are well documented, information on adherence to preconception supplements is scarce. The objective of this study was to describe the predictors of adherence to preconception and prenatal micronutrient supplementation among women participating in a randomized control trial in Vietnam.MethodsAdherence data were collected prospectively from a double blind randomized controlled trial in rural Vietnam. Five thousand eleven women of reproductive age were randomized to receive preconception supplements for weekly consumption containing either: Folic Acid, Iron and Folic Acid (IFA), or Multiple Micronutrients. Women who became pregnant received prenatal IFA supplements for daily consumption through delivery. Village health workers visited participants’ homes every two weeks to deliver supplements and record consumption and side effects. Multivariate logistic regression was used to assess individual, household, and programmatic predictors of supplement adherence.ResultsAdherence was high with 78 and 82% of the women consuming more than 80% of the preconception and prenatal supplements, respectively. Women of minority ethnicity (OR = 0.78 95% CI = 0.67, 0.91) and farmers (OR = 0.71 95% CI = 0.58, 0.88) were less likely to consume >80% of the preconception supplements while socioeconomic status (SES) (OR = 2.71 highest vs. lowest quintile; 95% CI = 2.10, 3.52) was positively associated with >80% adherence in the entire preconception sample with available information (n = 4417). Women in their first pregnancy had lower prenatal adherence compared to multiparous women. At the programmatic level, each village health worker visit was associated with higher odds of >80% adherence by 3–5% before pregnancy and 18% during pregnancy.ConclusionsKey determinants of adherence included SES, ethnicity, occupation (farmer) and parity which may be helpful for targeting women for counseling on supplement adherence. Increased contact with village health workers was positively associated with adherence to micronutrient supplementation both before conception and during pregnancy indicating the need for resources to support community outreach to women of reproductive age.Trial registration NCT01665378. Registered on August 12, 2012.

show abstract

Neither Preconceptional Weekly Multiple Micronutrient nor Iron–Folic Acid Supplements Affect Birth Size and Gestational Age Compared with a Folic Acid Supplement Alone in Rural Vietnamese Women: A Randomized Controlled Trial

Abstract: Weekly supplementation with MMs or IFA before conception did not affect birth outcomes compared with FA in rural Vietnamese women. The trial was registered at clinicaltrials.gov as NCT01665378.

Cited by 48 publications

References 29 publications

A Summary of Pathways or Mechanisms Linking Preconception Maternal Nutrition with Birth Outcomes

A Summary of Pathways or Mechanisms Linking Preconception Maternal Nutrition with Birth Outcomes

World Perspective on the Epidemiology of Stunting between 1990 and 2015

Predictors of adherence to micronutrient supplementation before and during pregnancy in Vietnam

Contact Info

Product

Resources

About