“…The turquoise module has hub genes involved in ion transmembrane transport, including VPS9D1 , KCNN1 , PRKAB2 and NDUFA4 (Table ; Boettger et al., ; Pitceathly et al., ; Sugimoto, Hatakeyama, & Isobe, ; Steinberg & Kemp, ); this observation together with the upregulation of the Magenta module, which is enriched for ion transport processes (Table ), suggests that ion transportation is activated in depigmented opossums. In contrast, several of the hub genes in the blue module participate in cell cycle processes, including TOP2B , NEK2 , KNSTRN , CDK5RAP2 , UBE2C and PBK (Table ), these genes act as positive signals for cell division (i.e., NEK2 , KNSTRN , CDK5RAP2 , UBE2C and PBK ; Boekhout & Wolthuis, ; Fang, Seki, & Fang, ; Rape & Kirschner, ; Rizkallah, Batsomboon, Dudley, & Hurt, ; Zhang et al., ) or for DNA replication (i.e., TOP2B ; Sakaguchi & Kikuchi, ). The downregulation of these genes in depigmented individuals and of other genes in the blue module (Tables , ) may indicate the inhibition of cellular proliferation in depigmented skin.…”