Nekrotisierende ulzerierende Keratopathie nach Lokalanästhetikamissbrauch

Ardjomand, Navid; Faschinger, C.; Haller-Schober, Eva-Maria; Scarpatetti, Michael; Faulborn, J.

doi:10.1007/s00347-002-0623-z

Cited by 17 publications

(10 citation statements)

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“…Among the effective compounds tested, pentamidine isethionate inhibited synthesis of DNA, RNA, phospholipids, and proteins, with amoebicidal and cysticidal properties seen at ϳ100 to 200 g per ml with variable results (11,19,73), while propamidine isethionate (DNA synthesis inhibitor) is used clinically against keratitis at a concentration of up to 1 mg per ml (13,16,17,23,27,32,33,35,36,38,42,46,53,70,(74)(75)(76)(77)(78)(79). Other drugs tested included diminazene aceturate, which binds to the groove between the complementary strands of DNA at regular intervals and thus distorts the helical structure.…”

Section: Nucleic Acid-acting Drugsmentioning

confidence: 99%

The Development of Drugs against Acanthamoeba Infections

Siddiqui

Aqeel

Khan

2016

Antimicrob Agents Chemother

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For the past several decades, there has been little improvement in the morbidity and mortality associated with Acanthamoeba keratitis and Acanthamoeba encephalitis, respectively. The discovery of a plethora of antiacanthamoebic compounds has not yielded effective marketed chemotherapeutics. The rate of development of novel antiacanthamoebic chemotherapies of translational value and the lack of interest of the pharmaceutical industry in developing such chemotherapies have been disappointing. On the other hand, the market for contact lenses/contact lens disinfectants is a multi-billion-dollar industry and has been successful and profitable. A better understanding of drugs, their targets, and mechanisms of action will facilitate the development of more-effective chemotherapies. Here, we review the progress toward phenotypic drug discovery, emphasizing the shortcomings of useable therapies.

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Section: Nucleic Acid-acting Drugsmentioning

confidence: 99%

The Development of Drugs against Acanthamoeba Infections

Siddiqui

Aqeel

Khan

2016

Antimicrob Agents Chemother

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“…[10] To our knowledge, this is the first report identifying intracorneal migration of intraocular silicone oil. The postulated route of entry of silicone oil into the corneal intrastromal space is via the breaks in the Descemet's layer.…”

Section: Discussionmentioning

confidence: 99%

Progressive keratoconus, retinal detachment, and intracorneal silicone oil with obsessive-compulsive eye rubbing

Panikkar¹,

Manayath²,

Rajaraman³

et al. 2016

Oman J Ophthalmol

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An 18-year-old boy with an obsessive–compulsive disorder of eye rubbing presented with forme fruste keratoconus (KC) and posterior subcapsular cataracts. After evaluation, he underwent phacoemulsification in his left eye with intraocular lens implantation. The aggressive eye rubbing, however, aggravated the rapid progression to established KC, and further acute corneal hydrops within 3 months. Within the next 3 months, the eye rubbing precipitated rhegmatogenous retinal detachments (RDs) in both eyes. Furthermore, after undergoing a combined cataract and RD surgery with belt buckling and silicone oil endotamponade in his right eye, the repeated eye rubbing caused extrusion of the implanted silicone oil into the subconjunctival space and within the corneal stroma. This is the first report to our knowledge describing this unique complication associated with eye rubbing. It also highlights the need for increased vigilance and care that needs to be directed toward patients predisposed to such complications.

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“…Of note, this patient was a medical doctor himself. [22] Yagci et al . (2011) reported that out of 19 men (26 eyes) admitted to hospital, ten patients (52.6%) reported that they were using topical anesthetics and the remaining nine were discovered to have been using topical anesthetic drops during hospitalization.…”

Section: Discussionmentioning

confidence: 99%

Topical ocular anesthetic abuse among Iranian welders: Time for action

Sharifi

Karamouzian

et al. 2013

Middle East Afr J Ophthalmol

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Purpose:The purpose of this study is to estimate the prevalence of topical ocular anesthetic abuse among welders in Iran and suggest public health solutions for this issue.Methods:In this cross-sectional study, 390 welders were randomly recruited and queried on the use of anesthetic drops. A questionnaire was administered through structured one-on-one interviews conducted by the first author.Results:A total of 314 welders (80.5%) declared that they had used topical anesthetics at least once during their working lives. Almost 90% of them stated a preference for self-treatment over seeking help from a physician due to cultural and financial reasons. The most commonly used topical anesthetic was tetracaine. Most of the subjects (97.4%) had obtained the drugs from pharmacies without a prescription.Conclusions:The prevalence of topical ocular anesthetic abuse among welders in Iran is alarmingly high and may partially be due to cultural issues. Although most physicians are aware that topical anesthetics should only be used as a diagnostic tool, there is a crucial need to re-emphasize the ocular risks associated with chronic use of these medications. Educational programs for both physicians and the public are necessary to address the problem.

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Nekrotisierende ulzerierende Keratopathie nach Lokalanästhetikamissbrauch

Abstract: Silicone oil can penetrate the corneal stroma in cases of defects in Descemets' membrane.

Cited by 17 publications

References 0 publications

The Development of Drugs against Acanthamoeba Infections

The Development of Drugs against Acanthamoeba Infections

Progressive keratoconus, retinal detachment, and intracorneal silicone oil with obsessive-compulsive eye rubbing

Topical ocular anesthetic abuse among Iranian welders: Time for action

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