Nematicidal activity of aqueous tinctures of plants against larvae of the nematode Strongyloides papillosus

O.O., Boyko

doi:10.47665/tb.38.2.046

Cited by 6 publications

(2 citation statements)

References 52 publications

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“…Few research on the use of bilobol as an anti‐cancer agent has been documented (Boyko & Brygadyrenko, 2021; Kim & Yim, 2022; Schulte et al, 2021; Tanaka et al, 2011; Xu et al, 2015). In research by Kim and Yim (2022), bilobol was separated by semi‐preparative HPLC, and the western blotting and cytotoxicity assay was used to describe apoptotic activities.…”

Section: Bilobolmentioning

confidence: 99%

Ginkgols and bilobols in Ginkgo biloba L. A review of their extraction and bioactivities

Boateng

2023

Phytotherapy Research

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Ginkgo biloba (GB) has enormous bioactives with anti‐bacterial, anti‐oxidant, anti‐cancer, and immune‐stimulating properties, with global sales exceeding $10 billion. The terpene trilactones (ginkgolides A, B, and C) and flavonoids (mostly quercetin, isorhamnetin, and kaempferol) have received the most significant focus in GB research to date, whereas other bioactive compounds such as ginkgols and bilobols with various bioactivities such as anti‐viral, anti‐oxidant, and anti‐tumor actions have received less attention. Therefore, for the first time, this review focused on GB ginkgols, bilobols extraction, and bioactivities. This review showed that petroleum ether and acetone extraction had successfully extracted ginkgols and bilobols. Furthermore, bioactivities such as anti‐tumor activity and so on have been demonstrated for ginkgols, and bilobols, providing theoretical justification for ginkgols and bilobol as raw material for nutraceuticals, functional foods, pharmaceuticals, and cosmeceuticals. Future research could look into other biological applications (such as anti‐oxidant, antitoxins, anti‐radiation, anti‐microbial, and antiparasite) and their applications in the pharmaceutical, cosmetic, and nutraceutical industries. Besides, the primary research should be on developing green and effective methods for preparing ginkgols and bilobols and fully utilizing their pharmacological activity. This will also provide a new avenue for efficiently utilizing these bioactive compounds.

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Section: Bilobolmentioning

confidence: 99%

Ginkgols and bilobols in Ginkgo biloba L. A review of their extraction and bioactivities

Boateng

2023

Phytotherapy Research

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“…Recently, researchers have been determining the disinfestation effectiveness of environmentally safe, natural agents against exogenous nematode stages in order to preserve the biocenosis and prevent environmental pollution with aggressive, chemical agents (Gortari et al, 2007;Maia Filho et al, 2013;Boyko & Brygadyrenko, 2017, 2019a, 2019b, 2021a, 2021b.…”

Section: Introductionmentioning

confidence: 99%

Effect of disinfectants on viability of Trichuris skrjabini eggs

Євстаф’єва

Petrenko

Peleno

et al. 2023

Regul. Mech. Biosyst.

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The nematodoses are considered the most numerous group of cosmopolitan diseases among animal and human parasitoses. The representatives of the genus Trichuris attract special attention as pathogens of nematodoses. Their high fecundity, resistance to the influence of environmental factors and the ability to disperse create a serious ecological hazard and the risk of new outbreaks of infestation. The aim of the research was to establish the ovicidal efficiency of modern disinfectants on the embryogenesis of eggs of Trichuris skrjabini nematodes isolated from sheep. In laboratory conditions, two preparations were tested, DZPT-2 (mixture of glutaraldehyde, sodium dodecyl sulfate, essential oil) and Dixclor (mixture of sodium bisulfate, sodium chlorite, sodium percarbonate) at different concentrations and times of exposure. We established that DZPT-2 disinfectant showed a high level of ovicidal efficiency (97.5–100%) against T. skrjabini eggs at 4.5% concentration during exposure for 6–12 h and 5.0% concentration during exposure for 3–12 h. Dixclor showed a high level of ovicidal efficiency (100%) against Trichuris eggs at a concentration of 0.24% for exposures of 12 and 24 hours. Decreasing the concentration of disinfectants reduced the level of their ovicidal efficiency and led to the development of a greater number of viable eggs of T. skrjabini. Degenerative changes in the test cultures of T. skrjabini eggs caused by the tested disinfectants were characterized by the appearance and accumulation of air bubbles under the egg shell, the cessation of embryonic development at the bean-like embryo stage, loosening and resorption of the embryo inside the eggs, thinning and destruction of their shell, deformation of the eggs, and swelling of the egg plugs. Such destructive changes in eggs in experimental test cultures were also confirmed by the indicators of their morphometric parameters. Under the influence of DZPT-2 and Dixclor on the 54th day of cultivation, the length of the eggs was lower by 3.9%, and their width was greater by 4.8–5.1% compared to similar indicators in the control test culture. The obtained results allow one to recommend the tested disinfectants in defined and effective concentrations and exposures for effective control and prevention of trichurosis on livestock farms.

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Diagnostic traits of medicinal herbal raw material of species of Thymus genus

Hrytsyna

Skybitska

Novikevich

2022

Regul. Mech. Biosyst.

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The paper presents the peculiarities of morphological-anatomical structure of the organs, which are diagnostic traits of herbal raw materials (HRM) of the commonest species of Thymus L. genus in the moderate climatic zone. We determined that the studied species develop a subshrub life form, which grows monopodially in Th. pulegioides and Th. marschallianus, and sympodially with mono-, di- and polycyclic types of monocarpic shoots in Th. serpyllum. Inflorescence is of thyrsoid type with opposite partial inflorescences, which are constituents of simple dichasia with monochasia. Macroscopic and microscopic diagnostic features of the HRM are structure and pubescence on the stem, leaves and flowers, the anatomical structure of which was studied on 20 µm thick transversal sections using a light microscope. In Th. pulegioides, stems are tetrahedral, pubescent on ribs with unicellular and two-cellular elbow-shaped hairs. Leaves are ovoid, covered by multiangular epidermis that bears diacytic stromas, sharpened capitate unicellular and two-cellular hairs and 10–12 cellular essential oil glandules. In Th. marschallianus, the stems are poorly tetrahedral, rounded, pubescent on the entire surface. Leaves are elliptic, the cells of the epidermis are elongated, significantly tortuous, with 10–12 cellular glandules, diacytic stromas, capitate and unicellular hairs. In Th. serpyllum, the stems are cylindric, pubescent all round. The leaves are elongated-elliptic, epidermis cells are oval, tortuous, stromas are diacytic, essential oil glandules are 8–10 cellular, number of papilla-like hairs is low. The petioles and lamina base of the studied species are pubescent on the sides with short, coned and elbow-shaped, 2–3 cellular hairs, among which there are long, 4–8 cellular hairs; the hairs in Th. serpyllum are multicellular, interrupted. In mesophyll, there are schizogenous essential oil reservoirs. In Th. marschallianus and Th. pulegioídes, the calyx is campanulate, bilabiate, and pubescent. The flower corolla is purple-violet, bilabiate, has tube and outward bend, pubescent inside with coned unicellular hairs, has essential oil glandules and glandular capitate hairs, and pubescence in the fauces comprises long unicellular hairs. In Th. pulegioídes, cells of the corolla epidermis are multiangular-shaped with insignificantly wavy walls, in Th. marschallianus ‒ rectangular with significantly wavy walls. Cells of the tube epidermis are rectangular, tortuous. Surface of the corolla of Th. serpyllum is pubescent on both sides with short, cone-like and three-cellular, interrupted hairs, and also capitate hairs, and has essential oil glandules. Epidermis cells are multi-angular, tubes – rectangular and narrow. The obtained results may be used for diagnostics of HRM of morphologically similar species during their preparation.

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Nematicidal activity of aqueous tinctures of plants against larvae of the nematode Strongyloides papillosus

Cited by 6 publications

References 52 publications

Ginkgols and bilobols in Ginkgo biloba L. A review of their extraction and bioactivities

Ginkgols and bilobols in Ginkgo biloba L. A review of their extraction and bioactivities

Effect of disinfectants on viability of Trichuris skrjabini eggs

Diagnostic traits of medicinal herbal raw material of species of Thymus genus

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