Nematicidal activity of furanocoumarins from parsley against<i>Meloidogyne</i>spp.

Caboni, Pierluigi; Saba, Marco; Oplos, Chrisostomos; Aissani, Nadhem; Maxia, Andrea; Menkissoglu‐Spiroudi, Urania; Casu, Laura; Ntalli, Nikoletta

doi:10.1002/ps.3890

Cited by 46 publications

(28 citation statements)

References 38 publications

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“…As a promising alternative to chemical nematicides, research on the botanical nematicide is receiving increasing attention . The current study found that crude extract of W. indica roots has strong nematocidal activity against J2 of M. incognita.…”

Section: Discussionmentioning

confidence: 70%

Control of root‐knot nematodes using Waltheria indica producing 4‐quinolone alkaloids

Jang

Dang²,

Choi

et al. 2019

Pest Management Science

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BACKGROUND: Waltheria indica exhibited strong nematocidal activity against Meloidogyne incognita, a causal agent of root-knot nematode disease. This study aimed to characterize the nematocidal metabolites and to evaluate the efficacy of the formulated extract of W. indica in the biological control of M. incognita under both pot and field conditions. W. indica (W. indica WP20) at 26.7, 53.4 and 106.8 mg a.i. kg −1 soil significantly reduced the formation of galls and egg masses on the roots of tomato plants in a dose-dependent manner. In addition, application of 20 mg a.i. per plant W. indica WP20 effectively reduced gall formation on the roots of melon plants and population density of nematode in soil compared with untreated control under field conditions. CONCLUSION: W. indica can be used as an effective botanical nematicide in the eco-friendly control of root-knot nematode disease. RESULTS: Three 4-quinolone alkaloids, 5 ′ -methoxywaltherione A, waltherione A and waltherione C, were isolated and characterized as nematocidal metabolites. 5 ′ -Methoxywaltherione A and waltherione A caused high mortality in juveniles of Meloidogyne arenaria, Meloidogyne hapla, M. incognita and Bursaphelenchus xylophilus, whereas waltherione C exhibited significant nematocidal activity against only root-knot nematodes. In pot experiments, application of a wettable powder-type formulation of the ethyl acetate extract of

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Section: Discussionmentioning

confidence: 70%

Control of root‐knot nematodes using Waltheria indica producing 4‐quinolone alkaloids

Jang

Dang²,

Choi

et al. 2019

Pest Management Science

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“…[ 35 ] The levels of psoralen, methoxsalen, oxypeucedanin, and bergapten from the methanolic extract of P. crispum aerial parts were measured before and they were 1.77–46.04 mg/kg of plant weight. [ 36 ] Pimpinella anisum oil was active against Gram-positive bacteria ( B. cereus and S. aureus ) with MIC of 62.5–125 μg/mL while its MIC against Gram-negative bacteria ( E. coli , Klebsiella pneumoniae and P. aeruginosa ) was >500 μg/mL and its methanolic extract showed MIC of 500 μg/mL against S. aureus . [ 37 ] The methanolic extract had MIC of 5000 μg/mL against S. aureus , E. coli , and P. aeruginosa .…”

Section: Discussionmentioning

confidence: 99%

Screening of fruits of seven plants indicated for medicinal use in Iraq

Aldulaimi

2017

Phcog Mag

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Introduction:Coumarins exert many biological effects in humans, animals, and plants, which make the evaluation of their biological activities and study of their role in ethnomedicine highly valued.Objectives:Here, we selected seven plants which have ethnopharmacological use as antimicrobial in Iraq and the aims were to quantify the two structural isomers bergapten and methoxsalen in their seeds, to evaluate the antibacterial activities against several clinical isolates, and to isolate bergapten and methoxsalen from Ammi majus.Materials and Methods:Seven plants were extracted by petroleum ether (PE) and ethanol (EtOH). Bergapten and methoxsalen were separated and purified by preparative thin-layer chromatography. Quantification of the furanocoumarins has been conducted by high-performance liquid chromatography, and all the plant extracts and pure compounds were checked for antibacterial activities utilizing alamar blue microplate assay.Results:Cuminum cyminum was deprived of bergapten and methoxsalen and methoxsalen was not detected from Apium graveolens. Bergapten was abundant in PE more than in EtOH; on the other hand, EtOH was rich in methoxsalen. The separation of the two structural isomers was performed using normal phase chromatography and ultraviolet light as an indicator. All extracts showed weak to moderate antibacterial activities against Gram-positive isolates which were more sensitive than the negative ones. C. cyminum extract was least active, uncover the antibacterial role of bergapten and methoxsalen.Conclusion:These findings support the medicinal use of seeds of seven plants from Apiaceae family and quantify the two pharmacologically important furanocoumarins (bergapten and methoxsalen).SUMMARY This study was conducted to evaluate the antibacterial activities of seven plants seeds used in local medicine in Iraq. High-performance liquid chromatography was used to quantify bergapten and xanthotoxin in non-polar and polar extracts of these seeds. This study supports the medicinal use of these plants and clarifies the role of bergapten and xanthotoxin in antibacterial activities of these plants. Abbreviations used: EtOH: Ethanol; MIC: Minimum inhibitory concentration; PE: Petroleum ether; Rf: Retardation factor; Rt: Retention time.

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“…In addition to coumarin's use as the lead compound for the preparation of potent pharmacological molecules, it has also received considerable research attention for its interesting insecticidal, nematicidal, allelopathic, and antimicrobial activities in agriculture. [8][9][10][11][12][13] From the literature, we found that the antifungal activity of coumarins was certainly related to the nonpolar substituent at its 8-position. 14) These findings have made coumarins a very attractive lead for further transformations at the 8-position with nonpolar substituents.…”

Section: Introductionmentioning

confidence: 99%

Design, synthesis, antifungal activity, and 3D-QSAR of coumarin derivatives

Yan

Peng

Wang

et al. 2018

Journal of Pesticide Science

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In our research, a series of 8-substituted coumarin derivatives were synthesized, and their structures were confirmed by FT-IR, 1 H-NMR, and MS (or HRMS). In activity screening, the synthesized compounds exhibited potent antifungal activity against 4 phytopathogenic fungi: Botrytis cinerea, Colletotrichum gloeosporioides, Fusarium oxysporum, and Valsa mali. Notably, 8-chloro coumarin and ethyl 8-chloro-coumarin-3-carboxylate showed the strongest fungus inhibition with EC 50 of 0.085 and 0.078 mmol/L against V. mali. Furthermore, 3D-QSAR models (CoMFA and CoMSIA) of the title compounds against V. mali were established on the basis of their antifungal activities. The results indicated that the appropriate small, hydrophilic and electron-withdrawing groups on coumarin's C-3 and C-8, respectively, could enhance the antifungal activity. The information obtained will be very helpful for designing new derivatives with high antifungal activities.

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Nematicidal activity of furanocoumarins from parsley againstMeloidogynespp.

Abstract: Parsley exhibits promising nematicidal activity as an organic amendment and as a source of nematotoxic furanocoumarins.

Cited by 46 publications

References 38 publications

Control of root‐knot nematodes using Waltheria indica producing 4‐quinolone alkaloids

Control of root‐knot nematodes using Waltheria indica producing 4‐quinolone alkaloids

Screening of fruits of seven plants indicated for medicinal use in Iraq

Design, synthesis, antifungal activity, and 3D-QSAR of coumarin derivatives

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