2005
DOI: 10.1016/j.pestbp.2004.11.008
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Nematocidal quassinoids and bicyclophosphorothionates: a possible common mode of action on the GABA receptor

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Cited by 16 publications
(17 citation statements)
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“…These molecules appear to block GABA receptors in a similar fashion as PTX (Watanabe et al 2000;Kuriyama et al 2005). It was also shown that other noncompetitive GABA receptor antagonists (namely, variants of 3-isopropyl-1-phospha-2,6,7-trioxabicyclo[2.2.2]octane 1-sulphides or 3-isopropyl-BPTs) were effective against Diplogastridae nematodes (Kuriyama et al 2005).…”
Section: Nematicidal Drugs Targeting Cys-loop Gaba Receptorsmentioning
confidence: 97%
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“…These molecules appear to block GABA receptors in a similar fashion as PTX (Watanabe et al 2000;Kuriyama et al 2005). It was also shown that other noncompetitive GABA receptor antagonists (namely, variants of 3-isopropyl-1-phospha-2,6,7-trioxabicyclo[2.2.2]octane 1-sulphides or 3-isopropyl-BPTs) were effective against Diplogastridae nematodes (Kuriyama et al 2005).…”
Section: Nematicidal Drugs Targeting Cys-loop Gaba Receptorsmentioning
confidence: 97%
“…Other nematicidal drugs such as the quassinoids have been shown to be effective on nematodes of the Diplogastridae family (Watanabe et al 2000;Kuriyama et al 2005). These molecules appear to block GABA receptors in a similar fashion as PTX (Watanabe et al 2000;Kuriyama et al 2005).…”
Section: Nematicidal Drugs Targeting Cys-loop Gaba Receptorsmentioning
confidence: 99%
“…Quassinoids act against insects, nematodes and weeds (Koul, 2008;Powell et al, 1998;Leskinen et al, 1984;Chitwod, 2002;Lin et al, 1995). In nematodes quassinoids acts as noncompetitive antagonists of the ionotropic GABARs to stabilize the closed conformation of the channel, resulting in the inhibition of the action of GABA (Kuriyama et al, 2005). No data are currently available concerning quassinoids fate in the environment.…”
Section: Triterpenoids (Intact and Degradated Tetranortriterpenoids Amentioning
confidence: 99%
“…It is interesting to note that quassinoids (e.g., samaderine B) (Fig. 4), plant-derived nematocidal terpenoids, proved to have a possible structural overlap with bicyclophosphorothionates (Kuriyama et al 2005).…”
Section: Trioxabicyclo[222]octanes and Their Derivativesmentioning
confidence: 99%