Immunity to Parasitic Infection 2012
DOI: 10.1002/9781118393321.ch12
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Nematoda: Ascaris lumbricoides

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“…However, our understanding of the larval migratory pathway and some of the biological properties of Ascaris larvae can only be obtained through post-mortem examination (Holland et al ., 2013 ). Consequently, the public health impact of larval ascariasis remains cryptic – with the potential for liver damage in humans, being especially underestimated (Dold, 2012 ) – and contributes to Ascaris being termed one of the most neglected of the neglected tropical diseases (Holland, 2013 ). The logistical and ethical consequences of investigating human larval ascariasis (Stephenson, 1987 ; Cooper et al ., 1992 ) have led to a reliance on animal models to explore the aspects of larval migration and its biological impact.…”
Section: Introductionmentioning
confidence: 99%
“…However, our understanding of the larval migratory pathway and some of the biological properties of Ascaris larvae can only be obtained through post-mortem examination (Holland et al ., 2013 ). Consequently, the public health impact of larval ascariasis remains cryptic – with the potential for liver damage in humans, being especially underestimated (Dold, 2012 ) – and contributes to Ascaris being termed one of the most neglected of the neglected tropical diseases (Holland, 2013 ). The logistical and ethical consequences of investigating human larval ascariasis (Stephenson, 1987 ; Cooper et al ., 1992 ) have led to a reliance on animal models to explore the aspects of larval migration and its biological impact.…”
Section: Introductionmentioning
confidence: 99%