Field experiment was conducted from March to July 2022 to identify the eco-friendly management of root-knot nematodes (Meloidogyne spp.) in okra (Abelmoschus esculentus) by using different soil amendments. The experiment was designed as a randomized complete block design with three replications and seven treatments viz., mustard oil cake at 1.41 kg/2m2 plot, poultry manure at 5.6 kg/2m2 plot, goat manure at 3.25 kg/2m2 plot, vermicompost at 4.30 kg/2m2 plot, nitrogen-phosphorus-potassium (NPK) at 125:110:110 g/2m2, Cartap hydrochloride 4% granule (GR) at 10 g/2m2 plot and control. Disease parameters such as root gall index and number of galls per plant, fresh shoot weight, and fresh root weight were recorded at 72, 105, and 120 days after sowing. Fruit yield was recorded after the final pod harvest. Cartap hydrochloride 4G, poultry manure, and mustard oil cake significantly reduced the root gall index as compared to the control. However, goat manure, vermicompost nitrogen, phosphorus, and potassium (NPK) did not give satisfactory results in reducing root gall index. The maximum yield of okra was recorded in the NPK treated plots although the root gall index was not much reduced. The research results indicated that the most effective treatment for reducing root-knot nematode disease and improving vegetative growth and yield of okra was poultry manure. Therefore, poultry manure along with mustard oil cake could be used as an alternative to highly hazardous and persistent chemical nematicides for the management of root-knot nematodes in okra.