Neoadjuvant and Adjuvant Chemotherapy of Cervical Cancer

Mallmann, Peter; Mallmann, Christoph

doi:10.1159/000449023

Cited by 15 publications

(13 citation statements)

References 7 publications

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“…So far, considering the fact that the clinical stage of early cervical cancer in situ is low, surgical excision of the uterus is mainly used to prevent the spread of cancer cells. If necessary, relevant radiotherapy and chemotherapy can be assisted before and after surgery to consolidate the treatment effect and improve the prognosis of survival time ( 8 - 10 ). At present, clinical studies have not yet clarified the specific pathology of cervical cancer.…”

Section: Discussionmentioning

confidence: 99%

Clinical value of traditional laparotomy, extensive vaginal hysterectomy, and laparoscope-assisted vaginal hysterectomy in the treatment of patients with cervical intraepithelial neoplasia III

Xu¹,

Wu²,

Huang³

et al. 2021

Transl Cancer Res TCR

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Background: Cervical cancer is a common malignant tumor in women. This study aims to explore the clinical effects of traditional laparotomy, extensive vaginal hysterectomy and laparoscope-assisted vaginal hysterectomy in the treatment of patients with cervical intraepithelial neoplasia III (CIN III).Methods: A total of 79 cases with CIN III in situ who were treated in our hospital from July 2015 to February 2017 were selected as the study participants. According to the different surgical methods employed, patients were divided into a laparotomy group (n=21), a vaginal group (n=26), and a laparoscope-assisted vaginal group (n=32). The operative indicators in the three groups were compared, as well as the operative complications, quality of life, and female sexual function.Results: The operation time, intraoperative blood loss, and hospitalization time in the laparotomy group were all significantly greater than those in the vaginal and laparoscope-assisted vaginal groups (P<0.05), and the operative time was the shortest in the vaginal group. There was no significant difference in postoperative recovery time, drainage tube removal time, and time to out-of-bed activation between the vaginal group and the laparoscope-assisted vaginal group (P>0.05). After surgery, the main complications were poor wound healing, infection, vaginal discharge, and neoplasms of the vagina, and the total incidence of complications in the laparotomy group was 19.04%, which was significantly higher than that in the vaginal group (3.84%) and the laparoscope-assisted vaginal group (3.12%) (P<0.05). Three months after surgery, the physical and emotional function scores of patients in the laparoscope-assisted vaginal group were significantly higher than those in the laparotomy and vaginal groups (P<0.05). Six months after surgery, there were no significant differences among the three groups in scores of libido, sexual intercourse pain, orgasm, or difficulty in sexual intercourse (P>0.05).Conclusions: Laparoscope-assisted vaginal hysterectomy has a short recovery time and a low incidence of complications in patients with early cervical cancer in situ. Compared with laparotomy and vaginal hysterectomy, laparoscope-assisted vaginal hysterectomy is more conducive to improving the postoperative quality of life of patients.

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Section: Discussionmentioning

confidence: 99%

Clinical value of traditional laparotomy, extensive vaginal hysterectomy, and laparoscope-assisted vaginal hysterectomy in the treatment of patients with cervical intraepithelial neoplasia III

Xu¹,

Wu²,

Huang³

et al. 2021

Transl Cancer Res TCR

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“…The clinical efficacy of patients after treatment was evaluated, the evaluation criteria are complete remission (CR, the lesions completely subsided for more than one month), partial remission (PR, the lesion has shrunk >50% for more than one month, and there is no trend of new lesions appearing, growing, or becoming serious), and uncontrolled (NC, the enlargement or reduction of the lesion is less than 50%, or discovery of the emergence, growth, and severity of new lesions) [ 13 ]. Total effective rate = (CR + PR)/total number × 100%.…”

Section: Methodsmentioning

confidence: 99%

Clinical Effects of Chinese Herbal Decoction Combined with Basic Chemoradiotherapy and Nursing Intervention in the Treatment of Cervical Cancer and the Effect on Serum CEA, CA125, and TNF-α Levels

Gao

Hou

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Objective. This study was aimed to investigate the clinical effect of Chinese herbal decoction combined with basic chemoradiotherapy and nursing intervention in the treatment of cervical cancer and the effect on serum carbohydrate antigen 125 (CA125), carcinoembryonic antigen (CEA), and tumor necrosis factor-α (TNF-α) levels. Methods. A total of 200 cervical cancer patients in our hospital from June 2015 to November 2018 were selected and randomly divided into a study group and a control group. The control group was given chemoradiotherapy and psychological nursing treatment, and the study group was given self-made Chinese herbal decoction on the basis of the control group. The clinical efficacy and serum CEA, CA125, and TNF-α levels were assessed. Results. After treatment, the total effective rate of the study group was significantly higher than that of the control group. The levels of serum CEA, CA125, and TNF-α were decreased in the two groups after treatment, and the decrease in the study group was more significant than that in the control group. After treatment, CD3+ and CD4+ levels were increased compared with those before treatment, and the increase in the study group was also more obvious than that of the control group. The level of CD8+ was decreased compared with before treatment, and the decrease in the study group was more notable than that of the control group. The two-year cumulative survival rate of the study group was markedly higher than that of the control group. The quality-of-life of patients treated for 3 months, 1 year, and 2 years was dramatically improved compared to before treatment. The incidence of adverse reactions in the study group was lower than that of the control group. Conclusion. The treatment of basic chemoradiotherapy and psychological nursing intervention combined with Chinese herbal decoction on cervical cancer patients can improve the clinical treatment effects, improve the patient’s body immunity, reduce serum CEA, CA125, and TNF-α levels, prolong survival time, improve life quality, and reduce the incidence of adverse reactions, and it is worthy of clinical promotion.

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“…The analysis of cancer biomarkers that can be differentially expressed in the presence of this severe disease is an enormous challenge for researchers. Despite routine cytological screening programmes and the availability of multiple modalities of treatment, late-stage disease is associated with a poor outcome [2,3]. There is an urgent need to develop novel molecular therapeutic targets for the treatment of precancerous lesions and cervical cancer to reduce its mortality.…”

Section: Introductionmentioning

confidence: 99%

CD74 and HLA-DRA in Cervical Carcinogenesis: Potential Targets for Antitumour Therapy

et al. 2022

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Background and Objectives: Abnormal expressions of CD74 and human leukocyte antigen-DR alpha (HLA-DRA) have been reported in various cancers, though their roles in cervical cancer remain unclear. This study aimed to evaluate the gene and protein expressions of CD74 and HLA-DRA in the progression from normal cervix to precancerous cervical intraepithelial neoplasia (CIN) and finally to squamous cell carcinoma (SCC). Materials and Methods: The gene expression profiles of CD74 and HLA-DRA were determined in formalin-fixed paraffin-embedded tissues, with three samples each from normal cervixes, human papillomavirus type 16/18-positive, low-grade CIN (LGCIN), high-grade CIN (HGCIN), and squamous cell carcinoma (SCC) using Human Transcriptome Array 2.0. Immunohistochemical expression of the proteins was semi-quantitatively assessed in another cohort of tissue microarray samples comprising 7 normal cervix cases, 10 LGCIN, 10 HGCIN, and 95 SCC. Results: The transcriptomics profile and proteins’ expression demonstrated similar trends of upregulation of CD74 and HLA-DRA from normal cervix to CIN and highest in SCC. There was a significant difference in both proteins’ expression between the histological groups (p = 0.0001). CD74 and HLA-DRA expressions were significantly associated with CIN grade (p = 0.001 and p = 0.030, respectively) but not with the subjects’ age or SCC stage. Further analysis revealed a positive correlation between CD74 and HLA-DRA proteins. Conclusions: CD74 appears to promote cervical carcinogenesis via oncogenic signalling mechanisms and may serve as a potential antitumour target. Additionally, the upregulation of HLA-DRA, often associated with stronger immunogenicity, could be a promising biomarker for developing immunotherapies.

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Neoadjuvant and Adjuvant Chemotherapy of Cervical Cancer

Cited by 15 publications

References 7 publications

Clinical value of traditional laparotomy, extensive vaginal hysterectomy, and laparoscope-assisted vaginal hysterectomy in the treatment of patients with cervical intraepithelial neoplasia III

Clinical value of traditional laparotomy, extensive vaginal hysterectomy, and laparoscope-assisted vaginal hysterectomy in the treatment of patients with cervical intraepithelial neoplasia III

Clinical Effects of Chinese Herbal Decoction Combined with Basic Chemoradiotherapy and Nursing Intervention in the Treatment of Cervical Cancer and the Effect on Serum CEA, CA125, and TNF-α Levels

CD74 and HLA-DRA in Cervical Carcinogenesis: Potential Targets for Antitumour Therapy

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