Neoadjuvant chemoradiotherapy in combined treatment of patients with rectal cancer

Майстренко, Н. А.; Галкин, В Н; Erygin, D. V.; Sazonov, A. A.

doi:10.24884/0042-4625-2017-176-4-31-38

VESTNIK KHIRURGII IMENI I.I.GREKOVA

2017

DOI: 10.24884/0042-4625-2017-176-4-31-38

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Neoadjuvant chemoradiotherapy in combined treatment of patients with rectal cancer

Н. А. Майстренко

В Н Галкин

D. V. Erygin

et al.

Abstract: OBJECTIVE. The article analyzed an efficacy and safety of application of neoadjuvant chemoradiotherapy (CRT) in elderly and senile patients with rectal cancer. MATERIAL AND METHODS. An analysis of treatment results was made in 267 patients, who were divided into two groups. The first group (n = 142) underwent combined treatment that included prolonged course of neoadjuvant CRT followed by surgery. The second group of 125 patients underwent surgery without application of CRT. The patients of both groups were su… Show more

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2024

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Cited by 2 publications

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Prediction of the efficacy of neoadjuvant chemoradiotherapy in patients with rectal cancer based on a texture analysis of T2-weighted magnetic resonance tumor image obtained at primary staging

Dayneko,

Berezovskaya,

Mirzeabasov

et al. 2024

Digital Diagnostics

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BACKGROUND: Recently, significant efforts have been undertaken to find potential noninvasive biomarkers for predicting the response of locally advanced rectal cancer to neoadjuvant chemoradiotherapy. AIM: To assess the texture characteristics of locally advanced rectal cancer in primary T2-weighted imaging (T2-WI) as a potential predictor for the efficacy of standard neoadjuvant chemoradiotherapy and develop a prediction system for the efficacy of neoadjuvant chemoradiotherapy based on them. MATERIALS AND METHODS: The retrospective study enrolled 82 patients with locally advanced rectal cancer who received combination treatment with neoadjuvant chemoradiotherapy. Patient data were divided into the training (n=58) and control (n=24) sets. For texture analysis, primary high-resolution T2-WI at the level of the tumor center, oriented perpendicular to the intestinal wall, was used. The texture analysis was performed by second-order statistics based on the gray-level co-occurrence matrices using MAZDA ver. 4.6 featuring the calculation of 11 texture parameters. In the training set, based on the morphological assessment of surgical specimens, significantly different texture analysis parameters were found for two groups of patients: neoadjuvant chemoradiotherapy responders (good prognosis group) and nonresponders (poor prognosis group). Accordingly, a scoring system was created for assessing the efficacy of neoadjuvant chemoradiotherapy. The system was tested on the control set, and diagnostic efficacy parameters were determined. RESULTS: In the training set, the good and poor prognosis groups differed significantly in five texture parameters: AngScMom (p=0.021), SumofSqs (p=0.003), SumEntrp (p=0.003), Entropy (p=0.038), and SumVarnc (p=0.015), for which the cutoff points were found. These parameters were applied to create the scoring system (excluding the Entropy parameter, which had a strong direct correlation with SumEntrp and the lowest area under the curve, and SumofSqs, which had low reproducibility). The diagnostic efficiency of the scoring system for predicting the response had sensitivity, specificity, positive-predictive value, and negative- predictive value of 72%, 69%, 70%, and 71% for the training set and 80%, 64%, 62%, and 82% for the control set, respectively. The areas under the ROC curve were 0.77 and 0.72 for the training and control sets, respectively. CONCLUSIONS: Texture analysis of the primary T2-WI of tumors in patients with locally advanced rectal cancer allows for predicting the efficacy of neoadjuvant chemoradiotherapy with moderate diagnostic efficiency. The results suggest good prospects for further research in this area.

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Prediction of the efficacy of neoadjuvant chemoradiotherapy in patients with rectal cancer based on a texture analysis of T2-weighted magnetic resonance tumor image obtained at primary staging

Dayneko,

Berezovskaya,

Mirzeabasov

et al. 2024

Digital Diagnostics

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Intra-arterial chemoembolization as a component of neoadjuvant treatment of rectal cancer. Literature review

Kalinin,

Kulikov,

Verkin

et al. 2024

Sibirskij nauchnyj medicinskij zhurnal

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Interventional oncology is a rapidly evolving field of cancer treatment. Minimally invasive techniques, such as transarterial embolization with chemotherapeutic and radioactive agents, are common treatments and are found in many guidelines for the treatment of primary and metastatic liver lesions. It is known that the growth and development of a malignant neoplasm is primarily determined by angiogenesis. Rapid growth is ensured where the formation is directly related to the arterial bed. Therefore, when the drug is injected into the target vessel and providing tissue ischemia, it is possible to achieve a high degree of tumor pathomorphosis. This technique has an advantage for patients who, in some cases, cannot be treated surgically, and also increases the effectiveness of the chemotherapeutic effect. With the advent of necessary equipment in hospitals and the accumulation of experience in the use of minimally invasive interventions, it became possible to implement a new method of treating tumors of various localizations. In this review, we consider the results of domestic and foreign authors on the topic of intra-arterial chemoembolization before surgical treatment in patients with rectal cancer. It is noted that the analysis of the literature revealed a small number of works devoted to the chosen topic, despite the relevance of this problem for modern oncology.

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Neoadjuvant chemoradiotherapy in combined treatment of patients with rectal cancer

Cited by 2 publications

References 6 publications

Prediction of the efficacy of neoadjuvant chemoradiotherapy in patients with rectal cancer based on a texture analysis of T2-weighted magnetic resonance tumor image obtained at primary staging

Prediction of the efficacy of neoadjuvant chemoradiotherapy in patients with rectal cancer based on a texture analysis of T2-weighted magnetic resonance tumor image obtained at primary staging

Intra-arterial chemoembolization as a component of neoadjuvant treatment of rectal cancer. Literature review

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