Neoadjuvant chemotherapy for initially unresectable intrahepatic cholangiocarcinoma

Bertrand, L; Gelli, Maximiliano; Pittau, Gabriella; Allard, Marc Antoine; Pereira, Bruno; Serji, Badr; Vibert, Éric; Castaing, Denis; Adam, René; Cherqui, Daniel; Cunha, Antonio Sa

doi:10.1002/bjs.10641

Cited by 201 publications

(112 citation statements)

References 25 publications

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“…We previously published data on ICC patients resected following SIRT for ICC 31 . A retrospective analysis of patients treated with chemotherapy suggested that patients who could be resected following neoadjuvant chemotherapy and patients with upfront surgery had similar outcomes 32 .…”

Section: Discussionmentioning

confidence: 99%

Radioembolization Plus Chemotherapy for First-line Treatment of Locally Advanced Intrahepatic Cholangiocarcinoma

et al. 2020

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Section: Discussionmentioning

confidence: 99%

Radioembolization Plus Chemotherapy for First-line Treatment of Locally Advanced Intrahepatic Cholangiocarcinoma

et al. 2020

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“…The early combination of different treatment modalities has been proposed to be beneficial for aggressive variants of ICC [ 4 ]. However, the longer the time of diagnosis is delayed, the more likely the ICC lesion will undergo a loco-regional extension around the adjacent normal tissues, thus resulting in a poor prognosis [ 5 ]. Identifying prognostic factors for ICC is therefore critical for the development of effective treatments for ICC.…”

Section: Introductionmentioning

confidence: 99%

Identification of prognostic factors for intrahepatic cholangiocarcinoma using long non-coding RNAs-associated ceRNA network

et al. 2020

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Background: Accumulating amount of evidence has highlighted the important roles of long non-coding RNAs (lncRNAs) acting as competing endogenous RNAs (ceRNAs) in tumor pathogenesis. However, the roles of long non coding RNAs (lncRNAs) in the lncRNA-related ceRNA network of intrahepatic cholangiocarcinoma (ICC) still remain enigmatic. The current study aims to identify prognostic factors in the lncRNA-related ceRNA network of ICC. Methods: The transcriptome sequencing data of lncRNAs, messenger RNA (mRNA) and microRNA (miR) were downloaded from the SRA and TCGA databases. Differentially expressed lncRNAs (DElncRNAs), DEmiRs and DEmRNAs were identified and adopted to construct an lncRNA-miR-mRNA ceRNA network. ICC-associated DEmRNAs were adopted to construct the protein-protein interaction (PPI) network. The expression of the top 6 genes in the hub module was validated with mRNA transcriptome sequencing data and ICC-related gene expression dataset GSE45001, followed by GO and KEGG pathway enrichment analysis. The relationship between the hub gene-associated ceRNA network and the overall survival of patients with ICC was predicted by conducting a Kaplan-Meier survival analysis. Results: Sixty co-expressed DEmRNAs were identified in the ceRNA network. The top 6 hub genes consisted of downregulated FOS, IGF2, FOXO1 and NTF3, upregulated IGF1R, and insignificantly downregulated HGF in ICC tissues, when compared to that of normal adjacent tissues, followed by the successful construction of lncRNA-miR-hub network consisting of 86 ceRNA modules. MME-AS1 and hsa-miR-182 were associated with overall survival in ICC patients. FOS, IGF1R, IGF2, FOXO1, and NTF3 might target "TGF-β signaling pathway", "the hedgehog signaling pathway", "retinol metabolism", or "type II diabetes mellitus" pathways respectively. Conclusion: These results indicate that FOS, IGF1R, IGF2, FOXO1, and NTF3 were useful prognostic factors in determining the prognosis of patients with ICC.

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“…The incidence of ICC has been increasing worldwide . While there have been advancements in the nonoperative management of ICC, surgical resection remains the only potentially curative treatment strategy . For select patients who undergo curative‐intent surgery, OS generally remains poor with nearly two‐thirds of patients recurring soon after surgery .…”

Section: Discussionmentioning

confidence: 99%

Discordance in prediction of prognosis among patients with intrahepatic cholangiocarcinoma: A preoperative vs postoperative perspective

Moro

Paredes

Farooq

et al. 2019

Journal of Surgical Oncology

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Background The objective of the current study was to characterize patients with intrahepatic cholangiocarcinoma (ICC) undergoing curative‐intent surgery with discordant preoperative and postoperative prediction scores and determine factors associated with prediction discrepancy. Methods Patients who underwent hepatectomy for ICC between 1990 and 2016 were identified in a multi‐institutional international database. Preoperative and postoperative prognostic models were designed and discordant prognostic scores were identified. A multivariable logistic regression analysis was completed to determined factors associated with score discordance. Results Among 1149 patients, those who had concordant prediction scores were older (median age, 60 vs 56), and more likely to have a smaller median tumor size (6.0 vs 7.5 cm) (all P < .05). On multivariable logistic analysis, patients with higher neutrophil‐lymphocyte ratio (odds ratio [OR], 1.14; 95% confidence interval [CI], 1.09‐1.19), higher CEA levels (OR, 1.25; 95% CI, 1.04‐1.50), larger tumors (OR, 1.10; 95% CI, 1.04‐1.15) and suspicious lymph nodes (OR, 2.05; 95% CI, 1.25‐3.36) were more likely to have preoperative and postoperative score discordance. Older patients had decreased odds of having score discordance (OR, 0.98; 95% CI, 0.96‐0.99). Patients with score discordance had worse overall survival compared with patients with concordant scores (median:15.9 vs 21.7 months, P < .05). Conclusion Score discordance may reflect an aggressive variant of ICC that would benefit from early integration of multidisciplinary treatment strategies.

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Neoadjuvant chemotherapy for initially unresectable intrahepatic cholangiocarcinoma

Cited by 201 publications

References 25 publications

Radioembolization Plus Chemotherapy for First-line Treatment of Locally Advanced Intrahepatic Cholangiocarcinoma

Radioembolization Plus Chemotherapy for First-line Treatment of Locally Advanced Intrahepatic Cholangiocarcinoma

Identification of prognostic factors for intrahepatic cholangiocarcinoma using long non-coding RNAs-associated ceRNA network

Discordance in prediction of prognosis among patients with intrahepatic cholangiocarcinoma: A preoperative vs postoperative perspective

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