Neoadjuvant chemotherapy for patients with locally advanced vulvar cancer

Abstract

Purpose of reviewStudies on treatment options for patients with locally advanced vulvar cancer (LAVC) are scarce, and highlevel evidence for a primary treatment choice is lacking. Furthermore, current treatment options are associated with extensive morbidity and high complication rates. More effective treatment options are urgently needed. This review describes current treatment possibilities, focusing on literature regarding neoadjuvant chemotherapy (NACT) followed by surgery. Recent findingsAlthough data are heterogeneous and limited, NACT followed by surgery might be an effective and well tolerated treatment alternative associated with lower morbidity compared with current treatment options, such as excenterative surgery or definitive chemoradiation.