Neoadjuvant Chemotherapy in Advanced Ovarian Cancer: A Single-Institution Experience and a Review of the Literature

Loizzi, Vera; Leone, Luca; Camporeale, A; Resta, Leonardo; Selvaggi, Luigi; Cicinelli, Ettore; Cormio, Gennaro

doi:10.1159/000447743

Cited by 10 publications

(6 citation statements)

References 19 publications

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“…Although surgery is preferred as the curative treatment for metastatic malignancies, a large number of affected people cannot be operated because of the strict indications [9]. OC patients with LM can also be beneficial from systemic treatments, including chemotherapy, radiotherapy, targeted therapy, and immunotherapy [10][11][12]. Although these treatments do prolong the progression-free survival, most patients would ultimately suffer from relapse or resistance [13].…”

Section: Ivyspring International Publishermentioning

confidence: 99%

The Importance of Marital Status in the Morbidity and Prognosis of Lung Metastasis in Newly Diagnosed Ovarian Cancer

Qian¹,

Chen²,

Peng³

et al. 2023

J. Cancer

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Objective:The study aimed to evaluate the risk factors for the morbidity and prognosis of lung metastases (LM) in patients with newly diagnosed ovarian cancer (OC), and further explore the important role of marital status. Materials and methods: Based on the Surveillance, Epidemiology, and End Results (SEER) dataset, OC patients from 2010 and 2019 were retrospectively analyzed. Logistic regression analysis and Kaplan-Meier method were applied to evaluate the vital factors of incidence and survival outcome in LM population. Cox regression analysis was performed to identify risk factors for the prognosis of OC patients with LM. The predictive potential was showed by two established nomograms and examined by the concordance index (C-index), calibration curves, the area under the curve (AUC), decision curve analyses (DCAs) and clinical impact curves (CICs). Results: There are 25,202 eligible OC patients were enrolled in the study, the morbidity of LM at 5.61%. Multivariable logistic regression models illustrated that chemotherapy (P<0.01), surgical treatment of bilateral or more areas (P<0.01), T stage (P<0.01), N1 stage (P<0.01), bone metastasis (P<0.01), brain metastasis (P<0.01) and liver metastasis (P<0.01) were all significantly connected with LM in OC. Multivariable Cox regression analyses illustrated that unmarried, radiotherapy, elder people and positive cancer antigen 125 (CA-125) were significantly associated with shorter survival time, while chemotherapy made contributions to improve survival. Our study found that marital relationships promoted LM and was associated with the better prognosis, while unmarried patients had the opposite results. With the further development of our research, the cross-action of social, economic and psychological factors together determined the great impact of marital status on the morbidity and prognosis of OC patients combined with LM. Finally, the stability of the models was proved by internal verification. Conclusion:The population-based cohort study provides references for guiding clinical screening and individualized treatment of OC patients with LM. Under the influence of society and economy, marital status is closely related to the morbidity and prognosis of OC, which can be an important direction to explore the risk of OC lung metastasis in the future.

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Section: Ivyspring International Publishermentioning

confidence: 99%

The Importance of Marital Status in the Morbidity and Prognosis of Lung Metastasis in Newly Diagnosed Ovarian Cancer

Qian¹,

Chen²,

Peng³

et al. 2023

J. Cancer

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“…OC has multiple cellular origins. The term tubo-ovarian cancer is often used because OC may manifest as an ovarian or fallopian tube mass or as a primary peritoneal cancer [32].…”

Section: Ovarian Cancermentioning

confidence: 99%

Radiomics Analysis in Ovarian Cancer: A Narrative Review

et al. 2021

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Ovarian cancer (OC) is the second most common gynecological malignancy, accounting for about 14,000 deaths in 2020 in the US. The recognition of tools for proper screening, early diagnosis, and prognosis of OC is still lagging. The application of methods such as radiomics to medical images such as ultrasound scan (US), computed tomography (CT), magnetic resonance imaging (MRI), or positron emission tomography (PET) in OC may help to realize so-called “precision medicine” by developing new quantification metrics linking qualitative and/or quantitative data imaging to achieve clinical diagnostic endpoints. This narrative review aims to summarize the applications of radiomics as a support in the management of a complex pathology such as ovarian cancer. We give an insight into the current evidence on radiomics applied to different imaging methods.

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“…In such cases, NACT (neoadjuvant chemotherapy) to shrink the tumor or de nitive chemotherapy seems feasible. Recently however, NACT has been reported to increase the risk of platinum-resistance recurrence in patients with stage IIIC and IV EOC, and showed no survival bene t in this patient population, [8,9]. These concerns, among others in the treatment of ovarian cancer, have necessitated efforts to search for novel and more effective therapeutic approaches.…”

Section: Introductionmentioning

confidence: 99%

Repurposing celecoxib for ovarian cancer treatment by targeting survivin signaling

Chuwa

2023

Preprint

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Background Ovarian cancer is the leading cause of deaths among gynecologic cancers. With a five-year survival rate just slightly above 45% and high rates of chemo-toxicity and chemo-resistance, the search for novel, more effective, and less toxic therapeutic approaches is thus imperative. In the current study, we aimed to explore the potential antitumor effect of a COX-2 inhibitor, celecoxib, using a panel of ten ovarian cancer cell lines derived from varying histology. Methods We analyzed anti-proliferative effect of celecoxib by cell viability assay using WST-8 (water-soluble tetrazolium salt solution). The compound’s effect on cell cycle progression and apoptosis were evaluated by flow cytometry. Western blotting was employed to explore its influence on apoptosis-related genes. Results Celecoxib significantly and, in a dose-dependent manner, inhibited proliferation of all analyzed ovarian cancer cell lines at IC50 ranging from 17µm ~ 45µm irrespective of their histological characteristics, arrested the cell cycle, and induced apoptosis (p < 0.001, treated vs. DMSO). Further exploration revealed that treatment of the cells with celecoxib caused cleavage of caspase-3 and down-regulation of survivin, the effects that were comparable across all analyzed cell lines and independent to autophagy. Conclusions The findings confirm the antitumor effect of celecoxib against a panel of ovarian cancer cells of varying histology by targeting the anti-apoptotic protein, survivin, and suggest that this may serve as a novel targeted therapeutic approach for ovarian cancer. Large-scale clinical trials are therefore warranted to further evaluate its efficacy, and for optimization.

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Neoadjuvant Chemotherapy in Advanced Ovarian Cancer: A Single-Institution Experience and a Review of the Literature

Cited by 10 publications

References 19 publications

The Importance of Marital Status in the Morbidity and Prognosis of Lung Metastasis in Newly Diagnosed Ovarian Cancer

The Importance of Marital Status in the Morbidity and Prognosis of Lung Metastasis in Newly Diagnosed Ovarian Cancer

Radiomics Analysis in Ovarian Cancer: A Narrative Review

Repurposing celecoxib for ovarian cancer treatment by targeting survivin signaling

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