Neoadjuvant Chemotherapy in Asian Patients With Locally Advanced Gastric Cancer

Xie, Tong; Peng, Zhi; Shen, Lin

doi:10.5230/jgc.2023.23.e12

Cited by 3 publications

(4 citation statements)

References 63 publications

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“…(2) A comparison was made between the 2 groups regarding intraoperative blood loss, surgical duration, surgical margin, number of LNs dissected, postoperative ambulation time, postoperative hospital stay, and postoperative time to passage of flatus. (3) The levels of serum CEA, AFP, CA125, and CA72-4 were compared between the 2 groups. (4) The Karnofsky Performance Status (KPS) scores were compared between the 2 groups.…”

Section: Observed Indexesmentioning

confidence: 99%

“…Therefore, the medical field has been actively exploring treatment methods to improve the prognosis of GC. [3,4] Neoadjuvant therapy has been used for the treatment of various other cancers, such as non-small cell lung cancer and head and neck cancer. [5,6] Furthermore, the feasibility of neoadjuvant chemotherapy (NAC) for GC is also being actively explored.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, the medical field has been actively exploring treatment methods to improve the prognosis of GC. [ 3 , 4 ]…”

Section: Introductionmentioning

confidence: 99%

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The impact of neoadjuvant chemotherapy on the clinical efficacy and serum tumor marker levels in patients undergoing radical surgery for gastric cancer

Li,

Geng

2024

Medicine

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The objective of this article is to study the impact of neoadjuvant chemotherapy (NAC) on the clinical efficacy and serum tumor marker levels in patients undergoing radical surgery for gastric cancer (GC). Thirty patients who underwent routine radical surgery for GC in our hospital from January 2020 to June 2021 were included in the control group. Thirty patients who underwent radical surgery for GC after receiving NAC from July 2021 to December 2022 were included in the observation group. The treatment outcomes of the observation group were assessed and analyzed. The surgical indicators, tumor markers, Karnofsky Performance Status (KPS), and occurrence of adverse reactions were compared between the 2 groups. Comparisons were made between the 2 groups in terms of surgical duration, number of lymph node dissections, intraoperative blood loss, time to postoperative ambulation, length of hospital stay, and time to postoperative passage of flatus (P > .05). The observation group had a higher proportion of R0 resection at the surgical margin compared to the control group (P < .05). The serum tumor markers of the 2 groups were compared before treatment (P > .05). After treatment, the levels of serum carcinoembryonic antigen, alpha-fetoprotein, cancer antigen 125, and carbohydrate antigen 72-4 decreased in both groups, and the observation group showed a greater reduction in these tumor marker levels compared to the control group (P < .05). The KPS scores of the 2 groups were compared before treatment (P > .05). After treatment, the KPS scores increased in both groups, with the observation group showing a higher improvement compared to the control group (P < .05). The overall incidence of adverse reactions, including incision infection, pleural effusion, pulmonary infection, intestinal obstruction, and gastric emptying disorders, was lower in the observation group (6.67%) compared to the control group (26.67%) (P < .05). The combination of NAC with radical surgery for GC is safe and feasible. It can significantly increase the R0 resection rate, effectively improve the levels of serum tumor markers, enhance patient’s quality of life, and result in fewer surgical adverse reactions.

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Section: Observed Indexesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The impact of neoadjuvant chemotherapy on the clinical efficacy and serum tumor marker levels in patients undergoing radical surgery for gastric cancer

Li,

Geng

2024

Medicine

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“…Незважаючи на суттєві досягнення у діагностиці та прогнозуванні, перед-, інтра-та післяопераційному веденні, розвитку хірургічної техніки, частота ускладнень після операцій з приводу злоякісних новоутворень (ЗН) шлунка практично не змінюється упродовж останніх років. Показники післяопераційних ускладнень суттєво різняться і досягають залежно від джерела, 20-40 % при лікарняній летальності -10-33 % [5].…”

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Problems of Surgical Treatment of Gastric Malignant Neoplasms Complications

Polyovyy,

Stets,

Bocharov

et al. 2023

CAOS

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The frequency of complications of malignant neoplasms (MN) of the stomach remains high (10-40 %) and does not show a constant tendency to decrease, despite the introduction of new methodological approaches.The aim of the study. To analyze the factors of successful surgical treatment of gastric lesions, which in turn can be a prerequisite for optimizing surgical tactics in such patients.Material and methods. The research design included a statistical analysis of the medical records of 6,885 oncological patients with abdominal localization of gastric MN and an assessment of the results of treatment of 56 patients with a complicated course of gastric MN. All patients involved in the study signed the appropriate informed consent. The average age of the patients was 56.3±8.61 years, men signiﬁ cantly predominated in the cohort of patients with gastric lesions – 76.79 % against 23.21 % women. Patients were managed according to the ESMO 2022 Gastric cancer Clinical Practice Guideline for diagnosis, treatment and follow-up.Research results. A special feature of gastric MN is its diagnosis in the late stages – the number of patients in the IV stage doubled the number of III stage patients and tripled the number of I-II stages patients. Among the gastric MN complications perforation was observed in 51.79 %, gastrointestinal bleeding in 26.79 %, andgastric stenosis in 21.43 %.Conclusions. The choice of the nature, scope and stages of surgical intervention in patients with gastric MN should take into account the prevalence of the oncological process, the nature and severity of complications, the presence of comorbidities and the characteristics of the patient’s condition. Water-electrolyte and metabolic disorders in complicated gastric MN require a longer period of correction with consideration of options for endoscopic recanalization and enteral therapy, which creates conditions for radical removal of the process during emergency surgical interventions. The contingent of patients with complicated forms of gastric MN requires a complex individual approach and optimized surgical treatment to ensure quality of life in the immediate and long-term postoperative periods.

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Surgical Tactics in Complicated Forms of Gastric Malignant Tumors

Polovyi,

Stets,

Bocharov

et al. 2023

Khark. Surg. Sch.

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Summary. Introduction. Malignant neoplasms of the stomach are of the most common oncological processes, showing a relatively high mortality. The number of complications of the gastric malignant tumours (MT) remains high, despite the improvement of diagnostic and treatment tactics. Aim. To analyse the structure of complications of gastric MT’s and to evaluate the efficacy of the modern surgical tactics in their treatment. Materials and methods. The study is based on the evaluation of the results of treatment of 84 patients with complications of gastric MT’s in compliance with international and national ethical standards. The average age of the patients was (57.3±8.72) years, men dominated (P<0.001) (77.4 %). The Charlson comorbidity index value is 5.78 (unadjusted for age) and 7.14 (adjusted for age). The diagnosis of gastric MT was verified morphologically; the diagnosis of complications was based on the relevant recommendations. Results. The structure of gastric MT’s complications was represented by perforations, which were observed in 42 patients (50.0 %), acute gastrointestinal bleeding in 23 patients (27.3 %), gastric stenosis of various degrees in 18 patients (21.4 %). In one case of sarcoma of the body of the stomach, intraoperatively a rare case of complication of gastric MT was diagnosed, a giant intramural hematoma of a rounded shape 25×22 cm pseudocystic formation. Subcompensated stenosis was observed in 16 (88.9 %) patients, in the rest patients it was decompensated. Radical surgical interventions were performed in 54.8 % of patients, various types of suturing of perforations were performed in 45.2 %. According to the severity of bleeding, patients with an average degree of severity prevailed – 18 (78.3 %) patients, one patient with stage II gastric cancer had mild bleeding, and 4 (17.4 %) patients had severe gastric bleeding. Surgical tactics consisted of an individualized step-by-step approach, which showed effectiveness, mortality was not observed in this group of patients. Conclusions. The nature, volume and stages of surgical intervention in patients with complicated forms of malignant gastric tumours should encompass the extensiveness of the oncological process, the features of the complications, and the patient’s condition. The applied surgical tactics allow to ensure sufficient efficiency of treatment of complications of gastric MT’s. The presence of water-electrolyte, metabolic disorders requires long-term and more extensive preoperative preparation.

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Neoadjuvant Chemotherapy in Asian Patients With Locally Advanced Gastric Cancer

Cited by 3 publications

References 63 publications

The impact of neoadjuvant chemotherapy on the clinical efficacy and serum tumor marker levels in patients undergoing radical surgery for gastric cancer

The impact of neoadjuvant chemotherapy on the clinical efficacy and serum tumor marker levels in patients undergoing radical surgery for gastric cancer

Problems of Surgical Treatment of Gastric Malignant Neoplasms Complications

Surgical Tactics in Complicated Forms of Gastric Malignant Tumors

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