Neoadjuvant chemotherapy increases the 5-year overall survival of patients with resectable cervical cancer: A systematic review and meta-analysis

Xu, Yunbao; Zhang, Mengting; Zhang, Jiaying; Ng, Derry Minyao; Chen, Xiaoxiao; Si, Yue-Xiu; Shi, Yetan; Li, Xiangyuan; Mao, Danyi; Ling, Yang

doi:10.1016/j.tjog.2021.03.008

Cited by 10 publications

(2 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Neoadjuvant chemotherapy (NACT) improved operability and subsequent treatment outcomes and may improve the long-term prognosis of resectable cervical cancer 8 . Platinum-based NACT showed a response rate of approximately 60% for patients with locally advanced cervical cancer 9 .…”

Section: Introductionmentioning

confidence: 99%

Targeting CD74-positive macrophages improves neoadjuvant therapy in cervical cancer as revealed by single-cell transcriptomics analysis

Wang,

Feng

et al. 2023

Preprint

View full text Add to dashboard Cite

Uterine cervical cancer (UCC) has the second-highest mortality rate among malignant tumors of the female reproductive system. Immune checkpoint inhibitors (ICIs) have emerged as a promising therapeutic strategy for cervical cancer. However, the efficacy of PD-1 (programmed cell death protein 1) blockade combined with neoadjuvant chemotherapy (NACT) and the ensuing alterations within the tumor microenvironment need further investigation. We conducted single-cell RNA sequencing using 46,950 cells from nine sequential human cervical cancer tissues representing different stages of NACT and PD-1 blockade combination therapy. We delineated the trajectory of cervical epithelial cells and unveiled crucial factors involved in the combination therapy. Cell communication analysis revealed the inferred interaction strength decreased between T cell-cancer cells, while the communication between macrophage-cancer cells intensified after NACT therapy. We verified that macrophages are necessary for PD-1 blockade combination to exert antitumor effects in vitro. Detailed analysis unraveled the CD74-positive macrophages frequently interacted with the immunoreactive Epi 3 subgroup during neoadjuvant combination therapy. CD74 upregulation limited phagocytosis and stimulated M2 polarization. The CD74 blockade enhanced macrophage phagocytosis, resulting in decreased viability of cervical cancer cells in vitro and in vivo. This study unveils the dynamic microenvironment of UCC influenced by NACT and PD-1 blockade combination therapy, and targeting CD74 was a potential strategy to augment the therapy efficacy.

show abstract

Section: Introductionmentioning

confidence: 99%

Targeting CD74-positive macrophages improves neoadjuvant therapy in cervical cancer as revealed by single-cell transcriptomics analysis

Wang,

Feng

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…[1][2][3][4][5] Despite of which cancer subtype and human papilloma virus (HPV) infection status, primary treatment with curative intent for women with cervical cancer consists of surgery (radical hysterectomy [RH] or radical trachelectomy), concurrent chemoradiation (CCRT), or a pretreatment therapy (neoadjuvant chemotherapy [NACT]) and a combination of these treatments; and in routine clinical practice, the treatment opinion is often based on the International Federation of Obstetrics and Gynecology (FIGO) cancer stage and sometimes according to the fertility consideration. 1,2,6 However, the complications of treatment either by surgery or by CCRT have persistent negative impacts on the physiological and psychological function of women. One of complications after treatment is pelvic floor dysfunction (PFD), which is a public health issue with significantly negative effects on quality of life (QoL).…”

mentioning

confidence: 99%

Neurogenic bladder in patients with cervical cancer after treatment

Lee

Wang

2021

Journal of the Chinese Medical Association

View full text Add to dashboard Cite

Proposing a novel care program: reminiscence therapy involved care for anxiety, depression, and quality of life in postoperative cervical cancer patients

Liu

Yuan

et al. 2021

Ir J Med Sci

View full text Add to dashboard Cite

Neoadjuvant chemotherapy increases the 5-year overall survival of patients with resectable cervical cancer: A systematic review and meta-analysis

Cited by 10 publications

References 41 publications

Targeting CD74-positive macrophages improves neoadjuvant therapy in cervical cancer as revealed by single-cell transcriptomics analysis

Targeting CD74-positive macrophages improves neoadjuvant therapy in cervical cancer as revealed by single-cell transcriptomics analysis

Neurogenic bladder in patients with cervical cancer after treatment

Proposing a novel care program: reminiscence therapy involved care for anxiety, depression, and quality of life in postoperative cervical cancer patients

Contact Info

Product

Resources

About