Neoadjuvant Gonadotropin-Releasing Hormone Therapy Before Surgery May Improve the Fertility Index in Undescended Testes: A Prospective Randomized Trial

Schwentner, Christian; Oswald, Josef; Kreczy, Alfons; Lunacek, Andreas; Bartsch, Georg; Deibl, Martina; Radmayr, Christian

doi:10.1097/01.ju.0000153562.07287.77

Cited by 102 publications

(42 citation statements)

References 23 publications

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“…27 There have been reports suggesting that administration of gonadotropin-releasing hormone (GnRH) either pre or postorchidopexy may improve fertility based on improved fertility indices (ascertained by proxy with the ratio of adult spermatogonia per tubule on testicular biopsies taken at the time of orchidopexy). [28][29][30] This is a highly controversial topic with conflicting recommendations having been published 28,31 and should therefore be regarded as experimental. There is paucity of data on long-term outcomes of hormone therapy, such as fertility and cancer development.…”

Section: Hormonal Stimulation/hormonal Therapymentioning

confidence: 99%

Canadian Urological Association-Pediatric Urologists of Canada (CUA-PUC) guideline for the diagnosis, management, and followup of cryptorchidism

Braga

Lorenzo

Romao

2017

CUAJ

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Section: Hormonal Stimulation/hormonal Therapymentioning

confidence: 99%

Canadian Urological Association-Pediatric Urologists of Canada (CUA-PUC) guideline for the diagnosis, management, and followup of cryptorchidism

Braga

Lorenzo

Romao

2017

CUAJ

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“…But there are studies that suggest an additional indication for hormone therapy, using GnRH analogues subsequently to orchidopexy, in order to stimulate the maturation and proliferation of germ cells and increase the fertility rates, with positive results 1,[7][8][9][10]24 .…”

Section: Discussionmentioning

confidence: 99%

“…Several studies justify its use, before and/or after surgery or even as monotherapy, with beneficial effects on fertility rates (increase in number and maturation of spermatogonia) 1,[7][8][9][10] . Other studies, however, show deleterious effects after the use of hormones, with changes in the histology of cryptic or contralateral testicles, such as an increase in the apoptosis rate and smaller number of germ cells 3,8,12 .…”

Section: Introductionmentioning

confidence: 99%

Effects of human chorionic gonadotropin on the normal testicular tissue of rats

et al. 2014

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PURPOSE:To investigate the effects of human chorionic gonadotropin (hCG) on the testicular tissue of young male rats. METHODS:Male Wistar rats were assigned to groups (10 rats/group).Control Group received subcutaneous saline solution; Group 1 received hCG 50UI/Kg/dose; and Group 2 received hCG 100UI/Kg/dose, daily for 15 days. Half was submitted to bilateral orchiectomy on the 16 th day and the other half 45 days after the beginning of the hormone application. Testicles were weighed, measured and has their volumes determined. The diameter of the tubules and the thickness of the seminiferous epithelium were measured. RESULTS:Control Group presented the highest values of testicles volume and weight. Rats in the Control presented normal histology.In G1 and G2 atrophy of the seminiferous tubules, apoptosis of germ cells and multinucleated giant cells were observed. Comparing groups, in the first operation Control rats had higher diameter values. In the second operation, the Control was only different from G1.As for thickness, Control had higher values in both operations. Comparing the time of operation, the diameter values were higher in G1and G2 in the second operation. For all groups, the thickness of the epithelium was higher in the second operation. CONCLUSIONS:Human chorionic gonadotropin is gonadotoxic in rats. This effect was temporary and can affect reproductive potential. The total recovery of testicular damage in the studied range could not be proved, and the effects were not dose-dependent.

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“…This is often used as adjuvant therapy in the form of synthetic hCG or luteinising hormone-releasing hormone (LHRH). Hormone therapy may be started at around 6 months of age (Schwentner et al, 2005). This treatment is thought to optimise the potential fertility of the child undergoing treatment.…”

Section: Inguinoscrotal Phasementioning

confidence: 99%

Textbook of Plastic and Reconstructive Surgery

Butler¹,

Ghali²,

Kalaskar³

2016

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A CIP catalogue record for this book is available from The British Library.This book is published under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International license (CC BY-NC-ND 4.0). This license allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licenses are available at http://creativecommons.org/ licenses/by/4.0The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. The user is advised to always check the product information and clinical procedures with the most up-to-date published product information and the most recent codes of conduct and safety regulations. The authors and the publishers do not accept responsibility or legal liability for any errors in the text or misuse or misapplication of material in this work.ISBN: 978-1-910634-37-0 (Hbk.) ISBN: 978-1-910634-38-7 (Pbk.) ISBN: 978-1-910634-39-4 (PDF) ISBN: 978-1-910634-40-0 (epub) ISBN: 978-1-910634-41-7 (mobi)

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Neoadjuvant Gonadotropin-Releasing Hormone Therapy Before Surgery May Improve the Fertility Index in Undescended Testes: A Prospective Randomized Trial

Cited by 102 publications

References 23 publications

Canadian Urological Association-Pediatric Urologists of Canada (CUA-PUC) guideline for the diagnosis, management, and followup of cryptorchidism

Canadian Urological Association-Pediatric Urologists of Canada (CUA-PUC) guideline for the diagnosis, management, and followup of cryptorchidism

Effects of human chorionic gonadotropin on the normal testicular tissue of rats

Textbook of Plastic and Reconstructive Surgery

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