Neoadjuvant intralesional methotrexate for juvenile xanthogranuloma in an adult

Abstract

Juvenile xanthogranuloma (JXG) is a non-Langerhans cell histiocytosis usually occurring in infants and typically located in the head or neck. 1 Clinically, solitary skin lesions are found in 60%-82% of patients and the most common variant is characterized by one yellowish nodule.Adult onset is rare, and although JXG is usually self-limiting in children, spontaneous resolution is uncommon at older ages. In addition, up to 50% of patients with spontaneous regression develop an atrophy or anetodermal area. 2 Thus, complete excision is frequently performed in this population subgroup to achieve better cosmetic results.In disseminated forms, different chemotherapy regimens, corticosteroids and other systemic therapies are used. Herein, we report a case