Neoadjuvant therapy for pancreas cancer: Global perspective and optimal care pathways in low to middle‐income countries

Rajappa, Senthil; Pinninti, Rakesh; Are, Chandrakanth

doi:10.1002/jso.26365

Cited by 3 publications

(2 citation statements)

References 30 publications

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“…is, unfortunately, only in 15-20% of the cases [51]. This survival rate is significantly lower than lung, colon, and breast cancer (25%, 63%, and 90%, respectively, according to the American Cancer Society [52]).…”

Section: Supplementary Materialsmentioning

confidence: 99%

“…This survival rate is significantly lower than lung, colon, and breast cancer (25%, 63%, and 90%, respectively, according to the American Cancer Society [52]). Treatment with FOLFIRINOX, which is a combination of folinic acid, 5-fluorouracil (5-FU), irinotecan, and oxaliplatin, has shown an improvement in survival rates compared to the use of gemcitabine [51]. However, this combination of chemotherapeutics is quite aggressive and cannot be applied to all patients [53].…”

Section: Supplementary Materialsmentioning

confidence: 99%

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Identification of the Biosynthetic Gene Cluster of New Piperazic Acid-Containing Lipopeptides with Cytotoxic Activity in the Genome of Marine Streptomyces PHM034

Ceniceros,

Cañedo,

Méndez

et al. 2023

Metabolites

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Three novel lipopeptides, PM130391 (1), PM130392 (2), and PM140293 (3) were obtained from cultures of Streptomyces tuirus PHM034 isolated from a marine sediment. Structural elucidation of the three compounds showed they belong to the nonribosomal peptides family, and they all contain an acylated alanine, three piperazic acids, a methylated glycine, and an N-hydroxylated alanine. The difference between the three compounds resides in the acyl chain bound to the alanine residue. All three compounds showed cytotoxic activity against human cancer cell lines. Genome sequence and bioinformatics analysis allowed the identification of the gene cluster responsible for the biosynthesis. Inactivation of a nonribosomal peptide synthase of this cluster abolished the biosynthesis of the three compounds, thus demonstrating the involvement of this cluster in the biosynthesis of these lipopeptides.

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Section: Supplementary Materialsmentioning

confidence: 99%

Section: Supplementary Materialsmentioning

confidence: 99%

Identification of the Biosynthetic Gene Cluster of New Piperazic Acid-Containing Lipopeptides with Cytotoxic Activity in the Genome of Marine Streptomyces PHM034

Ceniceros,

Cañedo,

Méndez

et al. 2023

Metabolites

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Best Practices for Delivering Neoadjuvant Therapy in Pancreatic Ductal Adenocarcinoma

Cloyd,

Sarna,

Arango

et al. 2024

JAMA Surg

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ImportanceNeoadjuvant therapy (NT) is an increasingly used treatment strategy for patients with localized pancreatic ductal adenocarcinoma (PDAC). Little research has been conducted on cancer care delivery during NT, and the standards for optimal delivery of NT have not been defined.ObjectiveTo develop consensus best practices for delivering NT to patients with localized PDAC.Design, Setting, and ParticipantsThis study used a modified Delphi approach consisting of 2 rounds of voting, and a series of virtual conferences (from October to December 2023) to reach expert consensus on candidate best practice statements generated from a systematic review of the literature and expert opinion. An interdisciplinary panel was formed including 47 North American experts from surgical, medical, and radiation oncology, radiology, pathology, gastroenterology, integrative oncology, anesthesia, pharmacy, nursing, cancer care delivery research, and nutrition as well as patient and caregiver stakeholders.Main Outcome and MeasuresStatements that reached 75% agreement or greater were included in final consensus statements.ResultsOf the 47 participating panel members, 27 (57.64%) were male, and the mean (SD) age was 47.6 (8.2) years. Physicians reported completing training a mean (SD) 14.6 (8.6) years prior and seeing a mean (SD) 110.6 (38.4) patients with PDAC annually; 35 (77.7%) were in academic practice. Final consensus was reached on 82 best practices for delivering NT. Of these, 38 statements focused on pre-NT practices, including diagnosis and staging (n = 15), evaluation and optimization (n = 20), and decision-making (n = 3); 29 statements defined best practices during NT, including initiation (n = 3), delivery of therapy (n = 8), restaging practices (n = 12), and management of complications during NT (n = 6); and 15 best practices were identified to guide treatment post-NT, focusing on surgery (n = 7), pathology (n = 4), and follow-up (n = 3).ConclusionsUsing a modified Delphi consensus technique, best practice guidelines were developed focusing on the optimal standards for delivering NT to patients with localized PDAC. Given the prognostic importance of completing multimodality therapy, efforts to standardize and optimize the delivery of NT represent an immediate opportunity to decrease care variation and improve outcomes for patients with PDAC. Future research should focus on validating and implementing best practice standards into clinical practice.

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Correlation between Angiotensin Inhibitor Administration and Longer Survival in Patients Who Underwent Curative Resection for Pancreatic Cancer

Yang,

Kang,

Kang

et al. 2024

Yonsei Med J

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Neoadjuvant therapy for pancreas cancer: Global perspective and optimal care pathways in low to middle‐income countries

Cited by 3 publications

References 30 publications

Identification of the Biosynthetic Gene Cluster of New Piperazic Acid-Containing Lipopeptides with Cytotoxic Activity in the Genome of Marine Streptomyces PHM034

Identification of the Biosynthetic Gene Cluster of New Piperazic Acid-Containing Lipopeptides with Cytotoxic Activity in the Genome of Marine Streptomyces PHM034

Best Practices for Delivering Neoadjuvant Therapy in Pancreatic Ductal Adenocarcinoma

Correlation between Angiotensin Inhibitor Administration and Longer Survival in Patients Who Underwent Curative Resection for Pancreatic Cancer

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