2024
DOI: 10.1002/vms3.1287
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Neoangiogenesis markers in canine urothelial carcinomas: A cross‐sectional study

Fabio Gentilini,
Roberta Salaroli,
Raimondo Tornago
et al.

Abstract: BackgroundIn humans, there is a growing body of evidence that neoangiogenesis is crucial for tumour growth and progression in urothelial carcinomas (UC) which also typically exhibit overactivation of the RAS‐MAPK pathway. In canine UC (cUC), the same pathway has been aberrantly activated due to V595E BRAF variant and BRAF inhibitors has been evaluated as more effective treatment. However, BRAF inhibition is hampered in humans by rapidly occurring of chemoresistance. Targeting angiogenesis has been speculated t… Show more

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