Neodymium and manganese ions co-doped whitlockite for temperature monitoring, photothermal therapy, and bone tissue repair in osteosarcoma

Heng, Chunning; Zheng, Xiaoyan; Hui, Junfeng; Ma, Xiaoxuan; Fan, Daidi

doi:10.1016/j.jcis.2023.09.186

Cited by 6 publications

(2 citation statements)

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“…OS is a highly lethal tumor with a high incidence in children and adolescents. ( Heng et al, 2024 ). Despite advances in the treatment of OS, including surgery and chemotherapy, overall patient survival has not improved significantly due to the unclear molecular mechanisms associated with OS tumorigenesis.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive transcriptomic analysis identifies SLC25A4 as a key predictor of prognosis in osteosarcoma

Zhang,

Wang,

Zhang

et al. 2024

Front. Genet.

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BackgroundOsteosarcoma (OS) is highly malignant and prone to local infiltration and distant metastasis. Due to the poor outcomes of OS patients, the study aimed to identify differentially expressed genes (DEGs) in OS and explore their role in the carcinogenesis and progression of OS.MethodsRNA sequencing was performed to identify DEGs in OS. The functions of the DEGs in OS were investigated using bioinformatics analysis, and DEG expression was verified using RT-qPCR and Western blotting. The role of SLC25A4 was evaluated using gene set enrichment analysis (GSEA) and then investigated using functional assays in OS cells.ResultsIn all, 8353 DEGs were screened. GO and KEGG enrichment analyses indicated these DEGs showed strong enrichment in the calcium signaling pathway and pathways in cancer. Moreover, the Kaplan-Meier survival analysis showed ten hub genes were related to the outcomes of OS patients. Both SLC25A4 transcript and protein expression were significantly reduced in OS, and GSEA suggested that SLC25A4 was associated with cell cycle, apoptosis and inflammation. SLC25A4-overexpressing OS cells exhibited suppressed proliferation, migration, invasion and enhanced apoptosis.ConclusionSLC25A4 was found to be significantly downregulated in OS patients, which was associated with poor prognosis. Modulation of SLC25A4 expression levels may be beneficial in OS treatment.

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Section: Discussionmentioning

confidence: 99%

Comprehensive transcriptomic analysis identifies SLC25A4 as a key predictor of prognosis in osteosarcoma

Zhang,

Wang,

Zhang

et al. 2024

Front. Genet.

View full text Add to dashboard Cite

show abstract

“…OS is a highly lethal tumor with a high incidence in children and adolescents. (Heng et al, 2024). Despite advances in the treatment of OS, including surgery and chemotherapy, overall patient survival has not improved significantly due to the unclear molecular mechanisms associated with OS tumorigenesis.…”

Section: Discussionmentioning

confidence: 99%