Neodymium‐Sensitized Nanoconstructs for Near‐Infrared Enabled Photomedicine

Yu, Zhongzheng; Chan, W.K.; Tan, Timothy Thatt Yang

doi:10.1002/smll.201905265

Cited by 35 publications

(20 citation statements)

References 123 publications

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“…Also, the value of I D /I G is being used to evaluate the degree of graphitization. 20 The intensity of the G band is higher than the peak of the D band with the I D /I G value of 0.844 ( Figure 1f ), implying that more sp 2 -hybridized carbon present as compared to sp 3 hybridized carbon. FTIR spectrum gives a qualitative idea about the functional group present on the surface of CNPs.…”

Section: Resultsmentioning

confidence: 94%

“…Recent years have witnessed the emergence of a plethora of fluorescent nanomaterials, having gained much attention in the field of bioimaging owing to their small sizes, low cost, high tuneable fluorescent properties, and their ease of interface with biological systems leading to widespread applications. 2,3 Many different fluorescent nanomaterials have already been used, such as rare-earth semiconductor quantum dots 4,5 , organic dyes 6, and polymer dots 7 .…”

mentioning

confidence: 99%

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Water soluble, red emitting, carbon nanoparticles stimulate 3D cell invasion via clathrin-mediated endocytic uptake

Singh

Guduru

Walia

et al. 2021

Preprint

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Bright, fluorescent nanoparticles with excitation and emission towards the red end of the spectrum are highly desirable in the field of bioimaging. We present here a new class of organic carbon-based nanoparticles (CNPs) with robust quantum yield and fluorescence towards the red region of the spectrum. Using organic substrates like para-phenylenediamine (PPDA) dispersed in diphenyl ether and reflux conditions, we achieved scalable amounts of CNPs of the average size of 25 nm. These CNPs were readily uptaken by different mammalian cells, and we show that they prefer clathrin-mediated endocytosis for their cellular entry route. Not only can these CNPs be specifically uptaken in cells, but they also stimulate cellular processes like cell invasion from 3D spheroid models. These new class of CNPs, which have sizes similar to proteinaceous ligands, hold immense potential for their surface functionalization, whereby they could be explored as promising bioimaging agents for biomedical imaging and intracellular drug delivery.

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Section: Resultsmentioning

confidence: 94%

mentioning

confidence: 99%

Water soluble, red emitting, carbon nanoparticles stimulate 3D cell invasion via clathrin-mediated endocytic uptake

Singh

Guduru

Walia

et al. 2021

Preprint

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“…For biodetection application, NIR dye/LnNP nanoprobes are excited by NIR radiation, which is located within a "biological transparency window," providing a backgroundfree signal and thus a remarkable sensitivity. [2,72] In most cases, the detection is based on energy transfer. The appearance of the analyte may affect the energy transfer process between NIR dye and LnNP by altering their spectral overlap [17,73,74] or distance.…”

Section: Luminescent Biodetectionmentioning

confidence: 99%

Luminescent nano‐bioprobes based on NIR dye/lanthanide nanoparticle composites

et al. 2021

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Near-infrared (NIR) light, which has ignorable tissue scattering/absorption, minimal photodamage, and no autofluorescence interference, is highly favorable for bioapplications. NIR dye and lanthanide-doped nanoparticle (LnNP), as representative NIR-excited luminescence probes, have attracted increasing interest due to their unique optical property and low biological toxicity. Design of luminescence probes based on NIR dye/LnNP nanocomposites cannot only integrate the advantages but also achieve additional functions via regulating internal energy transfer pathways. In this review, we focus on the most recent advances in the development of NIR dye/LnNP nanocomposites as potential bioprobes, which cover from their fundamental photophysics to bioapplications, including energy transfer mechanisms, interface engineering (involving binding interaction, distance, and aggregation as key factors), and their applications for dye-sensitized upconversion/downshifting luminescent bioimaging, detection of biomolecules, and NIR-triggered diagnosis and therapy. Some future prospects and efforts toward this active research field are also envisioned. K E Y W O R D S dye sensitization, energy transfer, interface engineering, lanthanide-doped nanoparticle, nano-bioprobe, NIR dye This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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“…Furthermore, semimetals are reported to show decent photothermal performance in the second near-infrared (NIR-II, 1000–1700 nm) range 28 – 31 . Semimetal-based photothermal agents (PTAs) can absorb the energy of NIR-II light and convert it to heat for photothermal therapy (PTT), and simultaneously generate photoacoustic signals for deep-tissue photoacoustic imaging (PAI) 32 – 36 . Semimetallic mesoporous nanomaterials are excellent candidates for multimodal theranostic agents with loading capacity and photothermal conversion ability.…”

Section: Introductionmentioning

confidence: 99%

Degradable mesoporous semimetal antimony nanospheres for near-infrared II multimodal theranostics

Chen

Zheng

et al. 2022

Nat Commun

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Metallic and semimetallic mesoporous frameworks are of great importance owing to their unique properties and broad applications. However, semimetallic mesoporous structures cannot be obtained by the traditional template-mediated strategies due to the inevitable hydrolytic reaction of semimetal compounds. Therefore, it is yet challenging to fabricate mesoporous semimetal nanostructures, not even mention controlling their pore sizes. Here we develop a facile and robust selective etching route to synthesize monodispersed mesoporous antimony nanospheres (MSbNSs). The pore sizes of MSbNSs are tunable by carefully controlling the partial oxidation of Sb nuclei and the selective etching of the as-formed Sb2O3. MSbNSs show a wide absorption from visible to second near-infrared (NIR-II) region. Moreover, PEGylated MSbNSs are degradable and the degradation mechanism is further explained. The NIR-II photothermal performance of MSbNSs is promising with a high photothermal conversion efficiency of ~44% and intensive NIR-II photoacoustic signal. MSbNSs show potential as multifunctional nanomedicines for NIR-II photoacoustic imaging guided synergistic photothermal/chemo therapy in vivo. Our selective etching process would contribute to the development of various semimetallic mesoporous structures and efficient multimodal nanoplatforms for theranostics.

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Neodymium‐Sensitized Nanoconstructs for Near‐Infrared Enabled Photomedicine

Cited by 35 publications

References 123 publications

Water soluble, red emitting, carbon nanoparticles stimulate 3D cell invasion via clathrin-mediated endocytic uptake

Water soluble, red emitting, carbon nanoparticles stimulate 3D cell invasion via clathrin-mediated endocytic uptake

Luminescent nano‐bioprobes based on NIR dye/lanthanide nanoparticle composites

Degradable mesoporous semimetal antimony nanospheres for near-infrared II multimodal theranostics

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