The interaction of suppliers and manufacturers based on flexible links within cluster unions allows to achieve a synergistic effect, i.e. exceeding the sum of indicators of individual components of cluster-businesses. This effect is provided by the advantages of deep specialization of enterprises, their access to new technologies and ability to use highly qualified specialists (while savings on transaction costs). Therefore, at the beginning of the 21st century, the clustering process covered more than 50% of the economies of developed countries. Consequently, this article discusses the development models of various clusters, including ones existing in the agro-industrial sector. Based on the study of international experience, the article proposes a phased algorithm for the formation of a grain cluster in Russia. The purpose of the research is the development of a model for the interaction of participants and the rationale for creating a grain cluster in Russia, which contributes to improving the management of the economies of agricultural regions. The cluster model proposed in the article can be used in other countries with high agricultural potential.