Neolignans and amide alkaloids from the stems of Piper kadsura and their neuroprotective activity

Futoquinol improves Aβ25–35‐induced memory impairment in mice by inhibiting the activation of p38MAPK through the glycolysis pathway and regulating the composition of the gut microbiota

“…Huang et al, 2021). PK mainly comprises amide alkaloids, neolignans, terpenes, and oxygenated cyclohexane compounds (H. Chen et al, 2022). Futoquinol (Fut) was extracted and separated from PK and found to demonstrate good neuroprotective effects.…”

“…PK has pharmacological effects, including anti‐neuroinflammation, anti‐oxidation, and anti‐inflammatory activity (T. Y. Huang et al, 2021). PK mainly comprises amide alkaloids, neolignans, terpenes, and oxygenated cyclohexane compounds (H. Chen et al, 2022). Futoquinol (Fut) was extracted and separated from PK and found to demonstrate good neuroprotective effects.…”

Rapid Analysis of Compounds from Piperis Herba and Piperis Kadsurae Caulis and Their Differences Using High-Resolution Liquid–Mass Spectrometry and Molecular Network Binding Antioxidant Activity

“…To further clarify and compare the differences in the compounds of Piperis Herba and Piperis Kadsurae Caulis, a high-resolution liquid–mass spectrometer, ZenoTOF 7600, was selected for rapid scanning and analysis. In previous studies, alkaloids were found to have significant pharmacological activities as the characteristic representative compounds of the two, but due to the similarity of their compounds and the limitation of controls, it is difficult to rapidly and accurately identify the compounds [ 7 ]. At present, the molecular network has been widely used in the rapid identification of compounds of natural medicines [ 8 ].…”

Galgravin Isolated from Piper kadsura Ameliorates Lipopolysaccharide (LPS)-Induced Endotoxemia in Mice

“…Many natural products with anti-inflammatory activity have been identified from medicinal plants, such as andrographolide [7,8], curcumin [9], fisetin [10], gossypol [11], and lycorine [12], suggesting that herbal medicine has therapeutic potential for treating sepsis [13]. Piper kadsura is a vine-like plant in southeast China and Taiwan [14][15][16], whereas its stem is widely used as a folk medicine for the treatment of rheumatoid arthritis, gouty arthritis, asthma, and cerebral ischemia [14]. Several bioactive ingredients of P. kadsura have been identified [14].…”

“…Piper kadsura is a vine-like plant in southeast China and Taiwan [14][15][16], whereas its stem is widely used as a folk medicine for the treatment of rheumatoid arthritis, gouty arthritis, asthma, and cerebral ischemia [14]. Several bioactive ingredients of P. kadsura have been identified [14]. Among them, galgravin (Figure 1A) is a tetrahydrofuran lignin [15,[17][18][19][20][21][22][23] exhibiting a neuroprotective effect in primary neuronal cultures [24], a cytotoxic effect in human leukemia tumor cells [19], and the inhibitory effect of excessive bone resorption in mouse bone marrow cells [22].…”