Neolignans and serratane triterpenoids with inhibitory effects on xanthine oxidase from Palhinhaea cernua

Li, Jing; Xu, Ping; Tan, Lei-Hong; Zou, Zhen‐Xing; Wang, Yikun; Long, Hong‐Ping; Zhang, Gan; Li, Guang; Xu, Kang‐Ping; Tan, Gui‐Shan

doi:10.1016/j.fitote.2017.04.005

Cited by 20 publications

(9 citation statements)

References 27 publications

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“…Flavonoid can inhibit the performance of xanthine oxidase and xanthine dehydrogenase, so that it can inhibit uric acid synthesis [25,26]. In addition, extract of M calabura stem bark contain triterpenoid and it was reported that triterpenoid and triterpenoid saponin or riparsaponin could significantly inhibit xanthine oxidase activity so that uric acid decreases in the blood [27,28].…”

Section: Discussionmentioning

confidence: 99%

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Effect of Muntingia calabura L. Stem Bark Extracts on Uric Acid Concentration and Renal Histopathology in Diabetic Rats

Safrida

Sabri

2019

Medicina

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Background and objectives: This study was designed to determine uric acid concentration and renal histopathology of Muntingia calabura L. stem bark extract in diabetic rats and to compare the natural product of M. calabura L. stem bark extract with allopurinol. Materials and Methods: A completely randomized design was used for the experiment, which consisted of six treatment groups, each consisting of four rats, as follows: 1) NR, normal rat; 2) KN, diabetic rat (negative control); 3) KP, diabetic rats given allopurinol 10 mg/kg body weight; 4) EM150, diabetic rats given the test extract 150 mg/kg body weight/day; 5) EM300, diabetic rats given the test extract 300 mg/kg body weight/day; and 6) EM450, diabetic rats given for extract 450 mg/kg body weight/ day. Results: The results showed that M. calabura L. stem bark extract decreased (p < 0.05) uric acid concentrations in diabetic rats and no specific damage to renal proximal tubular cells was seen. Conclusions: It was concluded that M. calabura L. stem bark extract has a potential as an antihyperuricemic in diabetic rats. The recommended dose was 300 mg/kg body weight to provide a significant effect on reducing the uric acid level in diabetic rats. Our results support the use of this plant for the treatment of degenerative and inflammatory diseases.

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Section: Discussionmentioning

confidence: 99%

“…Chen-Yu et al [27] reported that flavonoids in Davallia formosana extract can decrease uric acid levels by inhibition of xanthine oxidase enzyme. Specifically, plant phenolic compounds, such as phenolic acids and flavonoids, show strong antioxidant activity through scavenging free radical.…”

Section: Discussionmentioning

confidence: 99%

Effect of Muntingia calabura L. Stem Bark Extracts on Uric Acid Concentration and Renal Histopathology in Diabetic Rats

Safrida

Sabri

2019

Medicina

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“…The (Figure 2). 8 The large values of J 7,8 = 7.2 Hz suggested a threoconfiguration for compound 1, as in the cases of 7-O-ethylguaiacylglycerol, J 7,8 = 6.6 Hz for threo and J 7,8 = 5.0 Hz for the erythro-isomer. 9 The absolute configuration of compound 1 was determined from the circular dichroism (CD) spectrum (Figure 3).…”

Section: Resultsmentioning

confidence: 97%

Phenolic Constituents of Elsholtzia blanda Benth

Dung

Yến

Trang

et al. 2023

Natural Product Communications

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Objectives: Elsholtzia blanda Benth. is a Vietnamese medicinal plant, used to treat inflammation, cough, and flu. Therefore, this current study focused on the isolation of the active ingredients from this plant and their NO production inhibitory activity. Methods: E. blanda aerial parts were dried, minced, and ultrasonically extracted with methanol and further separated by various chromatographic methods. The chemical structures of isolates were revealed by nuclear magnetic resonance, high resolution lectrospray ionization mass spectrometry, and circular dichroism spectra. The nitric oxide inhibition effects were evaluated in lipopolysaccharide-activated RAW264.7 cells. Results: Ten phenolic components [1 new (1) and 9 known (2-10)] were isolated and their chemical structures determined. Compound 5 (innovanoside, IC50 = 19.23 ± 1.43 µM) and 6 (maltol- O- β-D-glucopyranoside, IC50 = 21.73 ± 1.27 µM) showed the highest activity, and 2-4 showed moderate inhibition (IC50 = 47.36 ∼ 57.29 µM). The other compounds were inactive with IC50 values >100 µM. Conclusions: One previously undescribed and 9 known phenolic components isolated from E. blanda have been screened for their nitric oxide inhibitory activity. Compounds 2-6 showed moderate to significant inhibition with IC50 values of 19.23∼57.29 µM.

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“…Palhinhaea cernua (family Lycopodiaceae) is widely distributed in southern and eastern China . The whole plants of P. cernua , called “Pu-Di-Wu-Gong” in Chinese, are traditionally used as an herbal medicine for relaxing tendons, healing contusions, and treating rheumatism. , Previous phytochemical investigations of P. cernua indicated the presence of flavones, neolignans, lycopodium alkaloids, and serratene-type triterpenoids. − As part of a search for structurally unique and biologically interesting natural products from plants of the family Lycopodiaceae, ,, the chemical components in the n -BuOH portion of the extract of P. cernua were investigated. As a result, eight new truxinate derivatives, palhinosides A–H ( 1 – 8 ), together with two known compounds, apigenin-7- O -(6″- O - p -coumaroyl)-β- d -glucopyranoside ( 9 ) and methyl 4-hydroxycinnamate ( 10 ), have been isolated.…”

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confidence: 99%

“…9,10 Previous phytochemical investigations of P. cernua indicated the presence of flavones, 11 neolignans, 12 lycopodium alkaloids, and serratene-type triterpenoids. 13−20 As part of a search for structurally unique and biologically interesting natural products from plants of the family Lycopodiaceae, 12,21,22 the chemical components in the n-BuOH portion of the extract of P. cernua were investigated. As a result, eight new truxinate derivatives, palhinosides A−H (1−8), together with two known compounds, apigenin-7-O-(6″-O-p-coumaroyl)-β-D-glucopyranoside (9) and methyl 4-hydroxycinnamate (10), have been isolated.…”

mentioning

confidence: 99%

Palhinosides A–H: Flavone Glucosidic Truxinate Esters with Neuroprotective Activities from Palhinhaea cernua

Tan

Zou

et al. 2020

J. Nat. Prod.

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Palhinosides A−H (1−8), new flavone glucosidic truxinate esters, including β-truxinate and μ-truxinate forms, were isolated from Palhinhaea cernua. Their structures were elucidated by extensive spectroscopic methods and chemical analyses. The flavone glucoside cyclodimers possess a unique cyclobutane ring in their carbon scaffolds. Compounds 2−7 represent three pairs of stereoisomers (2/3, 4/5, 6/7). The protective effects of 1−8 against the damage of HT-22 cells induced by L-glutamate were evaluated, and compounds 4 and 5 showed better neuroprotective effects than the positive control, Trolox.F lavone glucosidic truxinate esters are cyclodimeric derivatives containing an unusual cyclobutane ring in their carbon scaffolds. Flavonoid glucoside cyclodimers in truxillate or truxinate forms are unusual in plants, and to date only 13 derivatives have been reported from Monochaetum multiflorum, 1 Stachys aegyptiaca, 2 Itoa orientalis, 3 Paepalanthus geniculatus, 4 Ginkgo biloba, 5 Chamaerhodos altaica, and Potentilla anserine. 6,7 Some of these derivatives possess important pharmacological activities, including antioxidant, 4 antineuroinflammatory, and neuroprotective activities. 5 Palhinhaea cernua (family Lycopodiaceae) is widely distributed in southern and eastern China. 8 The whole plants of P. cernua, called "Pu-Di-Wu-Gong" in Chinese, are traditionally used as an herbal medicine for relaxing tendons, healing contusions, and treating rheumatism. 9,10 Previous phytochemical investigations of P. cernua indicated the presence of flavones, 11 neolignans, 12 lycopodium alkaloids, and serratene-type triterpenoids. 13−20 As part of a search for structurally unique and biologically interesting natural products from plants of the family Lycopodiaceae, 12,21,22 the chemical components in the n-BuOH portion of the extract of P. cernua were investigated. As a result, eight new truxinate derivatives, palhinosides A−H (1−8), together with two known compounds, apigenin-7-O-(6″-O-p-coumaroyl)-β-D-glucopyranoside (9) and methyl 4-hydroxycinnamate (10), have been isolated. Their structures were identified by analysis of 1D/2D NMR and MS data, as well as chemical analyses. These flavone glucoside cyclodimers were isolated from the family Lycopodiaceae for the first time. Herein, the isolation, structure elucidation, and neuroprotective effects of the new compounds are described.

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Neolignans and serratane triterpenoids with inhibitory effects on xanthine oxidase from Palhinhaea cernua

Cited by 20 publications

References 27 publications

Effect of Muntingia calabura L. Stem Bark Extracts on Uric Acid Concentration and Renal Histopathology in Diabetic Rats

Effect of Muntingia calabura L. Stem Bark Extracts on Uric Acid Concentration and Renal Histopathology in Diabetic Rats

Phenolic Constituents of Elsholtzia blanda Benth

Palhinosides A–H: Flavone Glucosidic Truxinate Esters with Neuroprotective Activities from Palhinhaea cernua

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