Neomerane-type sesquiterpenoids from Valeriana officinalis var. latifolia

Han, Zhu‐Zhen; Zu, Xianpeng; Li, Hui‐Liang; Chen, Bingyang; Liu, Qingxin; Hu, Xian-Qing; Yan, Zhaohui; Zhang, Wei‐Dong

doi:10.1016/j.tet.2013.12.005

“…The result suggested that V. officinalis extract was effective in modulating LPO induced by different pro-oxidant agents and because of that V. officinalis extract, functioning as an antioxidant agent, can be beneficial for reducing insomnia complications linked to oxidative stress [73]. peptide 25-35 (Aß [25][26][27][28][29][30][31][32][33][34][35] ). Cultured rat hippocampal neurons were exposed to Aß (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)) (25 µM) for 24-48 h, after which morphological and biochemical properties were evaluated.…”

Section: Pharmacological Activitymentioning

confidence: 99%

“…peptide 25-35 (Aß [25][26][27][28][29][30][31][32][33][34][35] ). Cultured rat hippocampal neurons were exposed to Aß (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)) (25 µM) for 24-48 h, after which morphological and biochemical properties were evaluated. The neuronal injury (decrease in cell reducing capacity and associated neuronal degeneration) evoked by Aß, and prevented by valerian extract.…”

Section: Pharmacological Activitymentioning

confidence: 99%

Valeriana Officinalis: A Review of Its Traditional Uses, Phytochemistry and Pharmacology

Nandhini

¹

,

Narayanan

²

,

Ilango

³

2018

Asian J Pharm Clin Res

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Valeriana is a well-known Indian traditional medicinal herb with sleep remedy. It has been used over the years to treat nervine and sedative in hysteria, epilepsy, and sedative in nervous anxiety. It has also been used as an aromatic stimulant and reported some distinctive indications, as well as its use for rheumatism, low-grade fevers, and aphrodisiac. It has been known to grow well in regions of Europe, parts of Asia and North America. This systematic review focuses on the ethnopharmacological uses of Valeriana, including recent advances on the phytochemical and pharmacological study of Valeriana officinalis. In addition, future developments and scenarios in the study of the plant have been proposed. Various literature and electronic databases such as PubMed, ScienceDirect, Springer, and Wiley were searched and data obtained. Other online academic libraries such as Google Scholar and ethnopharmacological literature were searched systematically for more information on the plant. In this paper, we have reviewed various research conducted on V. officinalis especially in areas of its ethnopharmacological use, phytochemicals, and pharmacology. This plant has been used medicinally for a minimum of 2000 years. It is used in the treatment of brain disorder and also used for the treatment of varied nervous disorders, antispasmodic, anthelmintic, diuretic, diaphoretic, and emmenagogue, and hysteria. More research is needed in the area of pharmacokinetics and toxicology to give further information on the clinical use and control the quality of the plant.

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“…Han et al isolated valeneomerins A-D, two unique neomerane-type sesquiterpenoids and two newer nor-sesquiterpenoids from the roots of V. officinalis. Their structures were characterized by elaborate spectroscopic analysis and Cu Ka X-ray crystallography [31]. Mirzaei and Dinpanah examined the applicability of hollow fiber-based liquid phase microextraction for the extraction and pre-concentration of valerenic acid earlier to its identification by reversed-phase high-performance liquid chromatography/ultraviolet [44].…”

Section: Phytochemistrymentioning

confidence: 99%

“…The result suggested that V. officinalis extract was effective in modulating LPO induced by different pro-oxidant agents and because of that V. officinalis extract, functioning as an antioxidant agent, can be beneficial for reducing insomnia complications linked to oxidative stress [73]. Fachinetto [25][26][27][28][29][30][31][32][33][34][35] ). Cultured rat hippocampal neurons were exposed to Aß (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35) (25 µM) for 24-48 h, after which morphological and biochemical properties were evaluated.…”

Section: Pharmacological Activitymentioning

confidence: 99%

“…Fachinetto [25][26][27][28][29][30][31][32][33][34][35] ). Cultured rat hippocampal neurons were exposed to Aß (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35) (25 µM) for 24-48 h, after which morphological and biochemical properties were evaluated. The neuronal injury (decrease in cell reducing capacity and associated neuronal degeneration) evoked by Aß, and prevented by valerian extract.…”

Section: Pharmacological Activitymentioning

confidence: 99%

See 1 more Smart Citation

Valeriana Officinalis: A Review of Its Traditional Uses, Phytochemistry and Pharmacology

Nandhini

¹

,

Narayanan

²

,

Ilango

³

2018

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Valeriana is a well-known Indian traditional medicinal herb with sleep remedy. It has been used over the years to treat nervine and sedative in hysteria, epilepsy, and sedative in nervous anxiety. It has also been used as an aromatic stimulant and reported some distinctive indications, as well as its use for rheumatism, low-grade fevers, and aphrodisiac. It has been known to grow well in regions of Europe, parts of Asia and North America. This systematic review focuses on the ethnopharmacological uses of Valeriana, including recent advances on the phytochemical and pharmacological study of Valeriana officinalis. In addition, future developments and scenarios in the study of the plant have been proposed. Various literature and electronic databases such as PubMed, ScienceDirect, Springer, and Wiley were searched and data obtained. Other online academic libraries such as Google Scholar and ethnopharmacological literature were searched systematically for more information on the plant. In this paper, we have reviewed various research conducted on V. officinalis especially in areas of its ethnopharmacological use, phytochemicals, and pharmacology. This plant has been used medicinally for a minimum of 2000 years. It is used in the treatment of brain disorder and also used for the treatment of varied nervous disorders, antispasmodic, anthelmintic, diuretic, diaphoretic, and emmenagogue, and hysteria. More research is needed in the area of pharmacokinetics and toxicology to give further information on the clinical use and control the quality of the plant.

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New Iridoids and Acyclic Monoterpenoids from the Roots and Rhizomes of Valeriana officinalis var. latifolia

Liu,

Wang,

Duan

et al. 2024

Chemistry & Biodiversity

0

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Five new iridoids, valeralides A–E (1–5), two new acyclic monoterpenoids, valeralides F (6) and G (7), together with two known iridoids (8 and 9), were isolated from the roots and rhizomes of Valeriana officinalis var. latifolia. Their structures were elucidated based on 1D and 2D NMR, as well as HR‐ESI‐MS spectroscopic data. The absolute configuration of compounds 1–4 were elucidated based on electronic circular dichroism (ECD) calculation. In addition, all the isolates were evaluated for their inhibition on nitric oxide production, cytotoxicity and anti‐influenza A virus activity.

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Neomerane-type sesquiterpenoids from Valeriana officinalis var. latifolia

Cited by 16 publications

References 13 publications

Valeriana Officinalis: A Review of Its Traditional Uses, Phytochemistry and Pharmacology

Valeriana Officinalis: A Review of Its Traditional Uses, Phytochemistry and Pharmacology

Valeriana Officinalis: A Review of Its Traditional Uses, Phytochemistry and Pharmacology

New Iridoids and Acyclic Monoterpenoids from the Roots and Rhizomes of Valeriana officinalis var. latifolia

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